Psychomotor Stimulant Addiction: A Neural Systems Perspective

A Neural Substrate of Prediction and Reward

1997 • 8,991 citations

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Drug Addiction, Dysregulation of Reward, and Allostasis

2001 • 2,820 citations

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

1999 • 1,536 citations

Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning

1996 • 1,470 citations

Neuronal Coding of Prediction Errors

2000 • 1,411 citations

Addiction and the brain: The neurobiology of compulsion and its persistence

2001 • 1,284 citations

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

2000 • 1,224 citations

Addiction, Dopamine, and the Molecular Mechanisms of Memory

2000 • 1,186 citations

Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers Evidence for Monoaminergic Mechanisms

1999 • 1,094 citations

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

2001 • 1,084 citations

Activation of memory circuits during cue-elicited cocaine craving.

1996 • 939 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior

2001 • 905 citations

The neuropsychological basis of addictive behaviour

2001 • 796 citations

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000 • 760 citations

Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine

1999 • 722 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Persistent Structural Modifications in Nucleus Accumbens and Prefrontal Cortex Neurons Produced by Previous Experience with Amphetamine

1997 • 712 citations

Involvement of the amygdala in stimulus-reward associations: Interaction with the ventral striatum

1989 • 662 citations

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

2000 • 640 citations

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

2001 • 622 citations

Amygdala circuitry in attentional and representational processes

1999 • 606 citations

Drug addiction: bad habits add up

1999 • 592 citations

Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues

1991 • 581 citations

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

1999 • 565 citations

Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction

2000 • 545 citations

The Role of the Nucleus Accumbens in Instrumental Conditioning: Evidence of a Functional Dissociation between Accumbens Core and Shell

2001 • 541 citations

Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons

2001 • 539 citations

Myths about the treatment of addiction

1996 • 528 citations

Postcocaine anhedonia. An animal model of cocaine withdrawal.

1991 • 505 citations

The domain of supervisory processes and the temporal organization of behaviour

1998 • 492 citations

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

2001 • 475 citations

Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats

2000 • 446 citations

Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving

1998 • 442 citations

Fos Protein Expression and Cocaine-Seeking Behavior in Rats after Exposure to a Cocaine Self-Administration Environment

2000 • 437 citations

Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

2000 • 412 citations

Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine.

1993 • 368 citations

Regional brain metabolic activation during craving elicited by recall of previous drug experiences

1999 • 348 citations

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine

1997 • 338 citations

Dopamine Attenuates Prefrontal Cortical Suppression of Sensory Inputs to the Basolateral Amygdala of Rats

2001 • 338 citations

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

1991 • 330 citations

6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine

1986 • 316 citations

Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour

2000 • 309 citations

Integrating systematic cue exposure with standard treatment in recovering drug dependent patients

1990 • 305 citations

Relapse to drug-seeking: neural and molecular mechanisms

1998 • 299 citations

Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors

2000 • 294 citations

Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.

1995 • 291 citations

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

2001 • 287 citations

The biological, social and clinical bases of drug addiction: commentary and debate

1996 • 277 citations

Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys

2002 • 274 citations

Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area

2000 • 268 citations

A triple dissociation of memory systems: Hippocampus, amygdala, and dorsal striatum.

1993 • 266 citations

Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine: Comparison with N-methyl-d-aspartate antagonists

1995 • 263 citations

A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior

1999 • 250 citations

Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine

1998 • 249 citations

Progression of Changes in Dopamine Transporter Binding Site Density as a Result of Cocaine Self-Administration in Rhesus Monkeys

2001 • 238 citations

Modulation of the Induction or Expression of Psychostimulant Sensitization by the Circumstances Surrounding Drug Administration

1998 • 228 citations

Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior

2001 • 218 citations

Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse

2000 • 213 citations

Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine

1997 • 210 citations

Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons

1998 • 209 citations

Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues

2001 • 203 citations

Dissociable Effects of Lidocaine Inactivation of the Rostral and Caudal Basolateral Amygdala on the Maintenance and Reinstatement of Cocaine-Seeking Behavior in Rats

2002 • 198 citations

Effects of medial prefrontal or anterior cingulate cortex lesions on responding for cocaine under fixed-ratio and second-order schedules of reinforcement in rats

1997 • 188 citations

Dopamine, addiction and reward

1992 • 179 citations

Cocaine self‐administration increases the incentive motivational properties of the drug in rats

1999 • 179 citations

Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule

2000 • 171 citations

Potent Regulation of Midbrain Dopamine Neurons by the Bed Nucleus of the Stria Terminalis

2001 • 167 citations

Brain Dopamine And Reward

1989 • 164 citations

Addiction changes orbitofrontal gyrus function: involvement in response inhibition

2001 • 163 citations

Differential involvement of amygdala subsystems in appetitive conditioning and drug addiction

2000 • 163 citations

Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement

1993 • 161 citations

Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure

2001 • 160 citations

A learning model of addiction.

1992 • 159 citations

Differential Contributions of the Basolateral and Central Amygdala in the Acquisition and Expression of Conditioned Relapse to Cocaine-Seeking Behavior

2001 • 157 citations

Memory facilitation produced by dopamine agonists: Role of receptor subtype and mnemonic requirements

1989 • 151 citations

Context-specific Enhancement of Glutamate Transmission by Cocaine

2000 • 149 citations

Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization

1999 • 143 citations

Addiction is a Brain Disease--And it Matters

1998 • 141 citations

Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task

1990 • 137 citations

Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons

1999 • 133 citations

Expression of Fos‐related antigens in the nucleus accumbens and associated regions following exposure to a cocaine‐paired environment

2000 • 127 citations

Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (“ecstasy”)

2001 • 107 citations

N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning.

2000 • 98 citations

Context-specific cross-sensitization between systemic cocaine and intra-accumbens AMPA infusion in the rat

1996 • 80 citations

Using cue reactivity to screen medications for cocaine abuse: A test of amantadine hydrochloride

1992 • 70 citations

DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference

1995 • 65 citations

Expression of cocaine sensitization: regulation by the medial prefrontal cortex

1999 • 60 citations

Involvement of the Nucleus Accumbens and Medial Prefrontal Cortex in the Expression of Conditioned Hyperactivity to a Cocaine-Associated Environment in Rats

2000 • 60 citations

Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

2000 • 57 citations

AMPA‐receptor involvement in c‐fos expression in the medial prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward

1999 • 54 citations

Limbic-Cortical-Ventral Striatal Activation during Retrieval of a Discrete Cocaine-Associated Stimulus: A Cellular Imaging Study with γ Protein Kinase C Expression

2001 • 53 citations

Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine

1998 • 42 citations

Conditioned reinstatement of drug-seeking behavior with a discrete compound stimulus classically conditioned with intravenous cocaine.

2001 • 41 citations

Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement

1996 • 24 citations

Cocaine self‐administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex

2001 • 24 citations

Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations

1999 • 15 citations

Cocaine‐induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens

1998 • 7 citations

Addiction and Glutamate-Dependent Plasticity

2003 • 5 citations

Dissociation of conditioned locomotion and Fos induction in response to stimuli formerly paired with cocaine.

2002 • 3 citations

Neuroplasticity of Addiction

2016 • 2 citations