Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Superantigens and Their Potential Role in Human Disease

1993 • 620 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

Methods and programs for direct-space exploitation of geometric redundancies

1976 • 383 citations

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.

1990 • 347 citations

Crystal structure of staphylococcal enterotoxin B, a superantigen

1992 • 304 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

1990 • 253 citations

Identification of the region of T cell receptor β chain that interacts with the self-superantigen MIs-1a

1990 • 242 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.

1992 • 208 citations

Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1

1994 • 171 citations

Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins

1993 • 137 citations

Structure of toxic shock syndrome toxin 1

1993 • 131 citations

Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype.

1991 • 130 citations

A system for collection and on-line integration of X-ray diffraction data from a multiwire area detector

1987 • 129 citations

Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity.

1993 • 122 citations

Vβ17 gene polymorphism in wild-derived mouse strains: Two amino acid substitutions in the Vβ17 region greatly alter T cell receptor specificity

1990 • 122 citations

Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.

1991 • 119 citations

Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class ii isotypes

1989 • 118 citations

Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E.

1992 • 116 citations

Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules.

1990 • 110 citations

Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules.

1989 • 105 citations

The α1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1

1990 • 100 citations

Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta.

1991 • 95 citations

The Bacterial and Mouse Mammary Tumor Virus Superantigens; Two Different Families of Proteins with the Same Functions

1993 • 91 citations

Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.

1993 • 89 citations

Direct binding of secreted T-cell receptor beta chain to superantigen associated with class II major histocompatibility complex protein.

1991 • 87 citations

Staphylococcal toxins bind to different sites on HLA-DR.

1991 • 86 citations

On the fast rotation function

1987 • 79 citations

Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses.

1992 • 75 citations

Localization of a site on bacterial superantigens that determines T cell receptor beta chain specificity.

1993 • 73 citations

T cell receptor alpha-chain influences reactivity to Mls-1 in V beta 8.1 transgenic mice.

1992 • 69 citations

Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells.

1990 • 68 citations

Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen.

1992 • 56 citations

Major histocompatibility complex-specific recognition of Mls-1 is mediated by multiple elements of the T cell receptor.

1993 • 50 citations

Control of T cell responses to staphylococcal enterotoxins by stimulator cell MHC class II polymorphism.

1991 • 46 citations

Localization of the immunologic activity in the superantigen Staphylococcal enterotoxin B using truncated recombinant fusion proteins.

1992 • 46 citations

Mutation of the disulfide loop in staphylococcal enterotoxin A. Consequences for T cell recognition.

1991 • 43 citations

Superantigens of microbial origin

1993 • 41 citations

T‐Cell Receptor β‐Chain Binding to Enterotoxin Superantigens

1993 • 38 citations

Skewed T cell receptor V_α repertoire among superantigen reactive murine T cells

1993 • 36 citations

Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules.

1994 • 36 citations

Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice.

1993 • 29 citations

Sequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1.

1992 • 29 citations

Interaction of the T cell receptor with bacterial superantigens

1993 • 25 citations

Superantigens —remnants of a past process?

1993 • 11 citations