Roles for calcium signaling in structural plasticity and pathology in the hippocampal system

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

The establishment of polarity by hippocampal neurons in culture

1988 • 1,820 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Neuronal activity triggers calcium waves in hippocampal astrocyte networks

1992 • 818 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

1989 • 733 citations

Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The “dormant basket cell” hypothesis and its possible relevance to temporal lobe epilepsy

1991 • 706 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture

1980 • 672 citations

Developmental Neurobiology

1991 • 659 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

Calcium regulation of the neuronal growth cone

1988 • 581 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Neurotransmitters in the regulation of neuronal cytoarchitecture

1988 • 525 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Entorhinal cortex pathology in Alzheimer's disease

1991 • 471 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Adhesion molecules and the hierarchy of neural development

1988 • 431 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

Calcium and the aging nervous system

1987 • 384 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes

1983 • 356 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease

1989 • 319 citations

Nerve growth factor affects11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report)

1992 • 319 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Regulation of neuronal function by calcium

1989 • 302 citations

Protection of Dentate Hilar Cells from Prolonged Stimulation by Intracellular Calcium Chelation

1989 • 292 citations

Kainic acid neurotoxicity toward hippocampal formation: Dependence on specific excitatory pathways

1980 • 286 citations

Neurotransmitters as developmental signals

1991 • 283 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

1988 • 252 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

1989 • 230 citations

Anticonvulsant drugs: mechanisms of action.

1986 • 228 citations

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus

1992 • 225 citations

Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system—I. Forebrain

1990 • 224 citations

Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

1988 • 223 citations

Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

1993 • 218 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

1991 • 213 citations

Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells

1988 • 212 citations

GABAergic hippocampal neurons resistant to ischemia-induced neuronal death contain the Ca2+-binding protein parvalbumin

1989 • 211 citations

Glia protect hippocampal neurons against excitatory amino acid‐induced degeneration: Involvement of fibroblast growth factor

1990 • 211 citations

NGF gene expression in actively growing brain glia

1991 • 210 citations

NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons

1989 • 204 citations

S100 beta stimulates calcium fluxes in glial and neuronal cells.

1992 • 199 citations

NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection

1990 • 196 citations

Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity

1992 • 193 citations

Introduction and Overview

1989 • 189 citations

Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry

1988 • 183 citations

Diminished Glucose Transport in Alzheimer's Disease: Dynamic PET Studies

1991 • 181 citations

Chapter 27 Chapter Seizures, neuropeptide regulation, and mRNA expression in the hippocampus

1990 • 166 citations

Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex

1991 • 160 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats

1992 • 158 citations

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

1992 • 137 citations

Corticosterone Exacerbates Kainate‐Induced Alterations in Hippocampal Tau Immunoreactivity and Spectrin Proteolysis In Vivo

1993 • 129 citations

Glucocorticoids and hippocampal damage

1987 • 120 citations

Calbindin-D28K (CaBP) levels and calcium currents in acutely dissociated epileptic neurons

1991 • 118 citations

Neurotrophic activity in the adult rat hippocampal formation: regional distribution and increase after septal lesion

1985 • 118 citations

Development and selective neurodegeneration in cell cultures from different hippocampal regions

1989 • 115 citations

Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons

1991 • 112 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Up regulation of calbindin-D28K mRNA in the rat hippocampus following focal stimulation of the perforant path

1991 • 104 citations

Developmental expression, compartmentalization, and possible role in excitotoxicity of a putative NMDA receptor protein in cultured hippocampal neurons

1991 • 99 citations

Interleukin-1 stimulates the beta-amyloid precursor protein promoter

1990 • 95 citations

Cellular signaling mechanisms common to the development and degeneration of neuroarchitecture. A review

1989 • 85 citations

Fibroblast Growth Factor Enhances Long‐term Potentiation in the Hippocampal Slice

1990 • 83 citations

The trophic theory of neural concentrations

1986 • 77 citations

Chapter 14 Activity-dependent ionic changes and neuronal plasticity in rat hippocampus

1990 • 74 citations

Target cell specificity of synaptic connections in the hippocampus

1991 • 68 citations

β-Amyloid precursor protein and alzheimer's disease: The peptide plot thickens

1992 • 60 citations

Acetylcholine potentiates glutamate-induced neurodegeneration in cultured hippocampal neurons

1989 • 58 citations

Influence of epidermal growth factor on long-term potentiation in the hippocampal slice

1989 • 55 citations

Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: Non-N-methyl-d-aspartate receptors

1992 • 50 citations

Localized calcium influx orients axon formation in embryonic hippocampal pyramidal neurons

1990 • 47 citations

Na+/Ca2+ exchange activity is increased in Alzheimer's disease brain tissues

1991 • 42 citations

Increased Expression of β‐Amyloid Protein Precursor and Microtubule‐Associated Protein τ During the Differentiation of Murine Embryonal Carcinoma Cells

1992 • 42 citations

Basic Fibroblast Growth Factor in Neurons and Its Putative Functions^a

1991 • 32 citations

Slice cultures as a model to study entorhinal‐hippocampal interaction

1993 • 30 citations

Biology of the Nerve Growth Cone

1986 • 26 citations

Aberrant protein phosphorylation and cytoarchitecture in Alzheimer's disease.

1989 • 19 citations

Regulation of Neuronal Cells and Astrocytes by Protease Nexin‐1 and Thrombin^a

1992 • 18 citations

Are Nerve Growth Factors Involved in Long-Term Synaptic Potentiation in the Hippocampus and Spatial Memory?

1988 • 10 citations