Neurotransmitters as developmental signals

Specification of Cerebral Cortical Areas

1988 • 3,021 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1983 • 1,877 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

GABA‐Benzodiazepine‐Barbiturate Receptor Interactions

1981 • 910 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

1989 • 733 citations

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation

1974 • 653 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

Calcium regulation of the neuronal growth cone

1988 • 581 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Serotonin Selectively Inhibits Growth Cone Motility and Synaptogenesis of Specific Identified Neurons

1984 • 544 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.

1989 • 484 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture

1988 • 437 citations

Functional receptors for neurotransmitters on astroglial cells

1987 • 436 citations

The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells

1986 • 431 citations

Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells

1987 • 430 citations

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

1975 • 411 citations

Ion Channels In Vertebrate Glia

1990 • 373 citations

Antagonism between bicuculline and GABA in the cat brain

1971 • 363 citations

Excitatory amino acids directly depolarize rat brain astrocytes in primary culture

1984 • 358 citations

Voltage-Dependent Calcium Channels in Glial Cells

1984 • 347 citations

The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells

1971 • 321 citations

D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system.

1988 • 311 citations

Electrically and chemically mediated increases in intracellular calcium in neuronal growth cones

1987 • 284 citations

Neurotransmitters as morphogens

1988 • 262 citations

Neuroscience approached through cell culture

1982 • 251 citations

The effect of potassium on neuronal differentiation in cultures of dissociated newborn rat cerebellum

1972 • 244 citations

Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum

1973 • 224 citations

Glutamate‐induced increase in intracellular Ca²⁺ concentration in isolated hippocampal neurones

1986 • 216 citations

Hormonal and humoral influences on brain development

1983 • 213 citations

Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells

1988 • 212 citations

Maturation-stimulation effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture.

1973 • 211 citations

Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide.

1987 • 209 citations

Morphological and Biochemical Alterations in Foetal Rat Brain Cells cultured in the Presence of Monobutyryl Cyclic AMP

1973 • 203 citations

Postnatal Gliogenesis in the Mammalian Brain

1975 • 193 citations

Selective Destruction of Neurons by a Transmitter Agonist

1977 • 193 citations

Neuronal death in the development of the vertebrate nervous system

1985 • 185 citations

Evidence for transient perinatal glutamatergic innervation of globus pallidus

1987 • 183 citations

EFFECTS OF NOREPINEPHRINE ON THE MORPHOLOGY AND SOME ENZYME ACTIVITIES OF PRIMARY MONOLAYER CULTURES FROM RAT BRAIN

1978 • 181 citations

Dopamine and serotonin inhibition of neurite elongation of different identified neurons

1988 • 174 citations

GFA Content, Glutamate Uptake and Activity of Glutamate Metabolizing Enzymes in Differentiating Mouse Astrocytes in Primary Cultures

1978 • 173 citations

Enzymatic and morphological properties of primary rat brain astrocyte cultures, and enzyme development in vivo

1978 • 161 citations

Neurotrophic effects of GABA in cultures of embryonic chick brain and retina

1988 • 160 citations

Plasticity in dendrites shown by continuous GABA administration in superior cervical ganglion of adult rat

1978 • 158 citations

GABA Induces Functionally Active Low‐Affinity GABA Receptors on Cultured Cerebellar Granule Cells

1984 • 157 citations

Alterations in Uptake and Release Rates for GABA, Glutamate, and Glutamine During Biochemical Maturation of Highly Purified Cultures of Cerebral Cortical Neurons, a GABAergic Preparation

1984 • 153 citations

gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites.

1981 • 150 citations

Development of excitatory amino acid induced cytotoxicity in cultured neurons

1990 • 148 citations

Excitotoxins: An Overview

1983 • 142 citations

Stimulation of astroglial serotonin receptors produces culture media which regulates growth of serotonergic neurons

1989 • 142 citations

Characterization of subtypes of excitatory amino acid receptors involved in the stimulation of inositol phosphate synthesis in rat brain synaptoneurosomes

1987 • 129 citations

Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells

1986 • 127 citations

The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival

1989 • 127 citations

Potassium concentration and number of neurons in cultures of dissociated ganglia

1970 • 124 citations

GABA influences the ultrastructure composition of cerebellar granule cells during development in culture

1984 • 123 citations

Glutamate‐Induced Increase in Intracellular Ca²⁺ in Cerebral Cortex Neurons Is Transient in Immature Cells but Permanent in Mature Cells

1989 • 116 citations

Ultrastructural localization of β-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain

1987 • 115 citations

Stimulation of the N-methyl-d-aspartate receptor promotes the biochemical differentiation of cerebellar granule neurons and not astrocytes

1989 • 110 citations

What, if anything, is a neurotrophic factor?

1988 • 108 citations

Is Alzheimer's disease an anterograde degeneration, originating in the brainstem, and disrupting metabolic and functional interactions between neurons and glial cells?

1989 • 108 citations

The Binding of the GAB A Agonist [³H]THIP to Rat Brain Synaptic Membranes

1982 • 102 citations

Effects of Neurotransmitters on Astrocyte Glycogen Stores In Vitro

1988 • 99 citations

GABA as a trophic factor during development

1983 • 97 citations

Novel neuron-related regulatory mechanisms for astrocytic glutamate and GABA high affinity uptake

1983 • 96 citations

Effect of depolarization on the maturation of cerebellar granule cells in culture

1988 • 93 citations

Brain microvessels are innervated by locus ceruleus noradrenergic neurons

1989 • 91 citations

The role of the noradrenergic system on the formation of synapses in the visual cortex of the rat

1982 • 91 citations

Developmental changes in muscarinic receptor-stimulated phosphoinositide metabolism in rat brain.

1987 • 89 citations

Analysis of Cyclic AMP‐Dependent Changes in Intermediate Filament Protein Phosphorylation and Cell Morphology in Cultured Astroglia

1986 • 88 citations

A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons

1987 • 87 citations

The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain

1986 • 87 citations

Effect of GABA-Administration on murine neuroblastoma cells in culture

1981 • 87 citations

In vitro neurotoxicity of excitatory acid analogues during cerebellar development

1986 • 83 citations

Characterization of [3H]muscimol binding to mouse brain membranes

1979 • 82 citations

Protein kinase C in astrocytes: a determinant of cell morphology

1986 • 82 citations

Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices

1986 • 79 citations

The trophic effect of gaba on cerebellar granule cells is mediated by gaba‐receptors

1985 • 75 citations

Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation andl-glutamate application

1987 • 75 citations

ROLE OF ASTROCYTES IN COMPARTMENTATION OF AMINO ACID AND ENERGY METABOLISM

1986 • 75 citations

THE ONTOGENY OF DOPAMINE‐DEPENDENT INCREASE OF ADENOSINE 3′,5′‐CYCLIC MONOPHOSPHATE IN THE CHICK RETINA

1978 • 74 citations

Glutamate receptor agonists increase intracellular Ca2+ independently of voltage-gated Ca2+ channels in rat cerebellar granule cells

1989 • 73 citations

Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx

1989 • 72 citations

Induction and maintenance of free postsynaptic membrane thickenings in the adult superior cervical ganglion

1979 • 72 citations

Differences between GABA Receptor Binding to Membranes from Cerebellum during Postnatal Development and from Cultured Cerebellar Granule Cells

1982 • 72 citations

Glial cell development in the rat optic nerve

1984 • 69 citations

Glutamate recognition sites in human fetal brain

1988 • 69 citations

Primary cultures of astrocytes from mammalian brain as a tool in neurochemical research.

1980 • 65 citations

Supersensitivity to the cyclic GMP response to glutamate during cerebellar maturation

1978 • 65 citations

Dibutyryl Cyclic AMP Treatment of Astrocytes in Primary Cultures as a Substitute for Normal Morphogenic and ‘Functiogenic’ Transmitter Signals

1990 • 61 citations

Differential Expression of Type A and Type B Monoamine Oxidase of Mouse Astrocytes in Primary Cultures

1982 • 60 citations

Regulation of Glycogen Metabolism in Primary and Transformed Astrocytes In Vitro

1983 • 59 citations

Central Adrenergic Regulation of Cerebral Microvascular Permeability and Blood Flow; Anatomic and Physiologic Evidence

1980 • 57 citations

Axo-glial synapses and GABA-accumulating glial cells in the embryonic neocortex of the rat

1979 • 57 citations

Effect of Repeated Treatment with a γ‐Aminobutyric Acid Receptor Agonist on Postnatal Neural Development in Rats

1987 • 56 citations

GABA down-regulates the GABA/benzodiazepine receptor complex in developing cerebral neurons

1988 • 53 citations

Muscarinic acetylcholine receptors on cultured glia cells

1982 • 53 citations

Polarographic measurement of oxygen uptake by astrocytes in primary cultures using the tissue-culture flask as the respirometer chamber

1979 • 52 citations

α-Receptor and cholinergic receptor-linked changes in cytosolic Ca2+ and membrane potential in primary rat astrocytes

1989 • 50 citations

Dissociation of the Stellate Morphology from Intracellular Cyclic AMP Levels in Cultured Rat Brain Astroglial Cells: Effects of Ganglioside GMland Lysophosphatidylserine

1987 • 49 citations

Accumulation of putative amino acid neurotransmitters, monoamines and d-Ala2-Met-enkephalinamide in primary astroglial cultures from various brain areas, visualized by autoradiography

1983 • 49 citations

Uptake of GABA and nipecotic acid in astrocytes and neurons in primary cultures: Changes in the sodium coupling ratio during differentiation

1986 • 49 citations

High affinity glutamate binding during postnatal development of rat cerebellum

1980 • 46 citations

γ‐Aminobutyric Acid Affects the Developmental Expression of Neuron‐Associated Proteins in Cerebellar Granule Cell Cultures

1986 • 44 citations

Organization of microfilaments in astrocytes that form in the presence of dibutyryl cyclic AMP in cultures, and which are similar to reactive astrocytes in vivo

1987 • 43 citations

GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors

1986 • 42 citations

Morphological differentiation of cultured astrocytes is blocked by cadmium or cobalt

1987 • 41 citations

Noradrenaline induced stimulation of oxidative metabolism in astrocytes but not in neurons in primary cultures

1990 • 41 citations

ACTIVITY AND ISOENZYME PATTERN OF LACTATE DEHYDROGENASE IN ASTROBLASTS CULTURED FROM BRAINS OF NEWBORN MICE

1979 • 41 citations

Trophic actions of GABA on the development of physiologically active GABA receptors.

1983 • 41 citations

Effect of serum withdrawal on Na⁺‐K⁺ ATPase activity in astrocytes cultured from dissociated brain hemispheres

1976 • 40 citations

Dihydropyridines change the uptake of calcium induced by depolarization into primary cultures of cerebellar granule cells

1985 • 39 citations

GABA agonist induced changes in ultrastructure and GABA receptor expression in cerebellar granule cells is linked to hyperpolarization of the neurons

1990 • 39 citations

Ontogeny of Receptor Binding Sites for [³H]Glutamic Acid and [³H]Kainic Acid in the Rat Cerebellum

1981 • 39 citations

GABA or sodium-bromide-induced plasticity of neurites of mouse neuroblastoma cells in culture

1983 • 38 citations

Temporal development of gaba agonist induced alterations in ultrastructure and gaba receptor expression in cultured cerebellar granule cells

1987 • 38 citations

Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation

1989 • 37 citations

Synaptic interactions in the GABA system during postnatal development in retina

1983 • 36 citations

Chronic administration of the GABA-transaminase inhibitor ethanolamine O-sulphate leads to up-regulation of GABA binding sites

1984 • 35 citations

Lack of Na⁺‐Independent Binding of [³H]GABA or [³H] Muscimol to Particulate Fractions of Cultured Astroblasts

1980 • 35 citations

Effects of Inhibitors of Protein Synthesis and Intracellular Transport on the γ‐Aminobutyric Acid Agonist‐Induced Functional Differentiation of Cultured Cerebellar Granule Cells

1990 • 35 citations

Development of potassium effects on ion concentrations and indicator spaces in rat brain-cortex slices during postnatal ontogenesis

1972 • 33 citations

Effect of Prolonged Sodium Bromide Administration on the Fine Structure of Dendrites in the Superior Cervical Ganglion of Adult Rat

1979 • 32 citations

Morphology and distribution of postnatally generated glial cells in the somatosensory cortex of the rat: an autoradiographic and electron microscopic study

1982 • 30 citations

Neurons from substantia nigra increase the efficacy and potency of second messenger arising from striatal astroglia dopamine receptor

1988 • 28 citations

GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development

1988 • 28 citations

Neurotransmitters as Morphogenetic Signals and Trophic Factors

1987 • 26 citations

Toxic effects of dl-α-aminoadipic acid on müller cells from rats in vivo and cultured cerebral astrocytes

1982 • 25 citations

Bicuculline Up‐Regulation of GABA_A Receptors in Rat Brain

1988 • 24 citations

Protein Synthesis in Astrocytes: 'Spontaneous' and Cyclic AMP-Induced Differentiation

1986 • 23 citations

Effects of taurine on cell morphology and expression of low-affinity GABA receptors in cultured cerebellar granule cells

1989 • 23 citations

The effect of K+ and glutamate receptor agonists on the membrane potential of suspensions of primary cultures of rat astrocytes as measured with a cyanine dye, DiS-C2-(5)

1988 • 23 citations

Protein synthesis by astrocytes in primary cultures

1981 • 22 citations

The binding properties and regional ontogeny for [³H]glutamic acid Na⁺‐independent and [³H]kainic acid binding sites in chick brain

1986 • 20 citations

γ‐Aminobutyric Acid Agonist‐Induced Alterations in the Ultrastructure of Cultured Cerebellar Granule Cells Is Restricted to Early Development

1988 • 19 citations

Classification and properties of acidic amino acid receptors in hippocampus. III. Supersensitivity during the postnatal period and following denervation.

1983 • 18 citations

Protein phosphorylation in primary astrocyte cultures treated with and without dibutyryl cyclic AMP

1987 • 18 citations

Light and electron microscopic localization of GABAA-receptors on cultured cerebellar granule cells and astrocytes using immunohistochemical techniques

1991 • 17 citations

Dissociated cells of foetal rat pallium grown in culture medium supplemented with noradrenaline: Effects on the expression of neuron-specific enolase and cell adhesion molecule L1

1986 • 17 citations

Development of Benzodiazepine and Picrotoxin (t‐Butylbicyclophosphorothionate) Binding Sites in Rat Cerebellar Granule Cells in Culture

1990 • 16 citations

A study of the actions of bromide on frog sympathetic ganglion

1982 • 15 citations

GABA receptor binding site “induction” in rabbit retina after nipecotic acid treatment: Changes during postnatal development

1986 • 15 citations

Multifunctional Roles for Neurotransmitters: The Regulation of Neurite Outgrowth, Growth-Cone Motility and Synaptogenesis

1987 • 15 citations

Morphological effects of excitatory amino acid analogs on primary astroglial cultures

1988 • 14 citations

Subchronic administration of GABAergic agonists elevates [3H]GABA binding and produces tolerance in striatal dopamine catabolism

1985 • 12 citations

Promotion by sodium bromide of functional synapse formation from foreign nerves in the superior cervical ganglion of adult rat with intact preganglionic nerve supply

1986 • 11 citations

Development of the γ‐Aminobutyric Acid Neurotransmitter System in the Rat Cerebral Cortex During Repeated Administration of the GABA‐Transaminase Inhibitor Ethanolamine O‐Sulphate

1986 • 10 citations

Gamma-Aminobutyric Acid as a Neurotrophic Agent

1988 • 4 citations

The effect of kainic acid on the developing chick retina

1986 • 4 citations

Nerve Growth Factor Effects on CNS Cholinergic Neurons In Vivo

1988 • 2 citations