Going both ways: Immune regulation via CD1d-dependent NKT cells

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

NKT cells: what's in a name?

2004 • 1,133 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

2001 • 864 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining

2002 • 758 citations

The unconventional lifestyle of NKT cells

2002 • 756 citations

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

1993 • 714 citations

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

2003 • 706 citations

Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

2003 • 698 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

2003 • 670 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells

2002 • 639 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

Distinct Functional Lineages of Human Vα24 Natural Killer T Cells

2002 • 567 citations

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

2001 • 556 citations

In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers

1999 • 551 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs

2002 • 529 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma

2003 • 412 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis

2001 • 390 citations

CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells

1999 • 386 citations

Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide

2002 • 382 citations

Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

2004 • 375 citations

Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide

2003 • 370 citations

Loss of IFN-γ Production by Invariant NK T Cells in Advanced Cancer

2001 • 370 citations

Therapeutic activation of Vα24+Vβ11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity

2003 • 361 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells

2001 • 351 citations

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 • 347 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

CD1d-dependent Activation of NKT Cells Aggravates Atherosclerosis

2004 • 327 citations

Immune suppression and skin cancer development: regulation by NKT cells

2000 • 327 citations

Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model

2003 • 313 citations

Bone Marrow NK1.1− and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host Disease

1999 • 312 citations

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

2001 • 299 citations

Activation of Natural Killer T Cells Potentiates or Prevents Experimental Autoimmune Encephalomyelitis

2001 • 294 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells

2003 • 290 citations

NKT cells — conductors of tumor immunity?

2002 • 289 citations

Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells

2003 • 279 citations

Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity

2003 • 278 citations

Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes

2001 • 273 citations

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

2001 • 270 citations

Circulating Vα24+ Vβ11+ NKT Cell Numbers Are Decreased in a Wide Variety of Diseases That Are Characterized by Autoreactive Tissue Damage

2001 • 269 citations

NKT cells are phenotypically and functionally diverse

1999 • 259 citations

Mouse Vα14inatural killer T cells are resistant to cytokine polarizationin vivo

2003 • 251 citations

Natural Killer Cells Determine Development of Allergen-induced Eosinophilic Airway Inflammation in Mice

1999 • 248 citations

NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance

2001 • 244 citations

CD1d-Restricted NKT Cells: An Interstrain Comparison

2001 • 229 citations

The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 • 219 citations

Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer

2002 • 212 citations

Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice

2000 • 210 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 203 citations

Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant Vα14-Jα281 TCR

2003 • 199 citations

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

1999 • 196 citations

NKT Cells from Normal and Tumor-Bearing Human Livers Are Phenotypically and Functionally Distinct from Murine NKT Cells

2003 • 183 citations

Regulation of Murine Cerebral Malaria Pathogenesis by CD1d-Restricted NKT Cells and the Natural Killer Complex

2003 • 182 citations

Predominance of NK1.1+TCRαβ+ or DX5+TCRαβ+ T Cells in Mice Conditioned with Fractionated Lymphoid Irradiation Protects Against Graft-Versus-Host Disease: “Natural Suppressor” Cells

2001 • 182 citations

Disseminated Varicella Infection Due to the Vaccine Strain of Varicella‐Zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells

2003 • 177 citations

NK T Cells Contribute to Expansion of CD8⁺T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus

2002 • 172 citations

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

2000 • 169 citations

Involvement of decidual Vα14 NKT cells in abortion

2000 • 169 citations

CD4⁺CD25⁺T cells responding to serologically defined autoantigens suppress antitumor immune responses

2003 • 168 citations

Suppression of collagen‐induced arthritis by natural killer T cell activation with OCH, a sphingosine‐truncated analog of α‐galactosylceramide

2004 • 166 citations

Cutaneous Immunization Rapidly Activates Liver Invariant Vα14 NKT Cells Stimulating B-1 B Cells to Initiate T Cell Recruitment for Elicitation of Contact Sensitivity

2003 • 165 citations

NKT Cells Inhibit the Onset of Diabetes by Impairing the Development of Pathogenic T Cells Specific for Pancreatic β Cells

2002 • 163 citations

Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission

2003 • 162 citations

TCR V alpha 24 and V beta 11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation.

1997 • 159 citations

Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide

2001 • 156 citations

Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice

2001 • 152 citations

α-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis

2003 • 149 citations

CD4+ Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice

2000 • 147 citations

Cutting Edge: Compartmentalization of Th1-Like Noninvariant CD1d-Reactive T Cells in Hepatitis C Virus-Infected Liver

2002 • 138 citations

Cutting Edge: Vα14-Jα281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice

2002 • 138 citations

Structural Features of the Acyl Chain Determine Self-phospholipid Antigen Recognition by a CD1d-restricted Invariant NKT (iNKT) Cell

2003 • 137 citations

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

2003 • 133 citations

CD1-specific T cells in microbial immunity

2001 • 129 citations

The Vα14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex

2002 • 128 citations

Activation of invariant NKT cells by αGalCer administration protects mice from MOG35–55‐induced EAE: critical roles for administration route and IFN‐γ

2003 • 126 citations

CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site

2003 • 124 citations

Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of Vα14 NK T Cells

2001 • 123 citations

Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells

2002 • 123 citations

Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice

1999 • 121 citations

Natural killer T cells: natural or unnatural regulators of autoimmunity?

2003 • 120 citations

Repeated α-Galactosylceramide Administration Results in Expansion of NK T Cells and Alleviates Inflammatory Dermatitis in MRL-lpr/lpr Mice

2003 • 116 citations

Resistance to Metastatic Disease in STAT6-Deficient Mice Requires Hemopoietic and Nonhemopoietic Cells and Is IFN-γ Dependent

2002 • 110 citations

Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides

2004 • 101 citations

Development and selection of NKT cells

2002 • 100 citations

Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis

2003 • 98 citations

Preserved IFN‐α production of circulating Vα24 NKT cells in primary lung cancer patients

2002 • 96 citations

Immune Tolerance to Combined Organ and Bone Marrow Transplants After Fractionated Lymphoid Irradiation Involves Regulatory NK T Cells and Clonal Deletion

2002 • 91 citations

Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR

2003 • 87 citations

α-Galactosylceramide: Potential Immunomodulatory Activity and Future Application [General Articles]

2004 • 78 citations

NKT cells: Potential targets for autoimmune disease therapy?

2002 • 76 citations

CD8+NKR-P1A+ T cells preferentially accumulate in human liver

1999 • 75 citations

Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-FaslprMice: An Example of Disease Regulation at the Organ Level

2001 • 75 citations

Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL‐4 and eotaxin production

2004 • 75 citations

Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation

2001 • 72 citations

Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.

1997 • 70 citations

Natural Killer T Cells Restricted by the Monomorphic MHC Class 1b CD1d1 Molecules Behave Like Inflammatory Cells

2002 • 68 citations

CD1d deficiency exacerbates inflammatory dermatitis in MRL‐lpr/lpr mice

2004 • 65 citations

Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

1997 • 65 citations

CD1d1-Dependent Control of the Magnitude of an Acute Antiviral Immune Response

2004 • 59 citations

High Frequency of Vα24+ Vβ11+ T-Cells Observed in Type 1 Diabetes

2002 • 58 citations

Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies

2004 • 54 citations

In vitro anti-tumour activity of α-galactosylceramide-stimulated human invariant Vα24+NKT cells against melanoma

2001 • 45 citations

Frequency of Vα24+CD161+ natural killer T cells and invariant TCRAV24-AJ18 transcripts in atopic and non-atopic individuals

2003 • 18 citations