Cutaneous Immunization Rapidly Activates Liver Invariant Vα14 NKT Cells Stimulating B-1 B Cells to Initiate T Cell Recruitment for Elicitation of Contact Sensitivity

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

2001 • 864 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

2003 • 706 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo

2000 • 589 citations

Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

1995 • 569 citations

Critical contribution of liver natural killer T cells to a murine model of hepatitis

2000 • 532 citations

NK cells and NKT cells in innate defense against viral infections

2001 • 436 citations

Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis

2001 • 390 citations

Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model

2003 • 313 citations

Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

1997 • 291 citations

Circulating Vα24+ Vβ11+ NKT Cell Numbers Are Decreased in a Wide Variety of Diseases That Are Characterized by Autoreactive Tissue Damage

2001 • 269 citations

α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria

2000 • 261 citations

Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

2000 • 256 citations

CD1d-restricted Help To B Cells By Human Invariant Natural Killer T Lymphocytes

2003 • 242 citations

Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice

1998 • 233 citations

The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

2000 • 222 citations

Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by α-Galactosylceramide in Mice

2001 • 217 citations

Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi

2000 • 189 citations

Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions.

1975 • 186 citations

T cell-dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity.

1980 • 162 citations

An early component of delayed-type hypersensitivity mediated by T cells and mast cells.

1983 • 153 citations

α-Galactosylceramide Induces Early B-Cell Activation through IL-4 Production by NKT Cells

2000 • 141 citations

CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus

2001 • 138 citations

Defective elicitation of delayed-type hypersensitivity in W/Wv and SI/SId mast cell-deficient mice.

1983 • 124 citations

B Cell–dependent T Cell Responses

2002 • 119 citations

Early Local Generation of C5a Initiates the Elicitation of Contact Sensitivity by Leading to Early T Cell Recruitment

2000 • 116 citations

CD4+ Valpha14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major

2000 • 113 citations

Fas/Fas Ligand Interactions Promote Activation-Induced Cell Death of NK T Lymphocytes

2000 • 110 citations

Delayed-type hypersensitivity is mediated by a sequence of two different T cell activities.

1984 • 106 citations

Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha.

1999 • 105 citations

Vascular Endothelial Cell Expression of ICAM-1 and VCAM-1 at the Onset of Eliciting Contact Hypersensitivity in Mice: Evidence for a Dominant Role of TNF-α

1999 • 95 citations

Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice

2003 • 94 citations

Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies.

1997 • 93 citations

Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.

1996 • 89 citations

Required Early Complement Activation in Contact Sensitivity with Generation of Local C5-dependent Chemotactic Activity, and Late T Cell Interferon γ: A Possible Initiating Role of B Cells

1997 • 84 citations

Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity.

1984 • 84 citations

Mast cell activation and vascular alterations in immediate hypersensitivity-like reactions induced by a T cell-derived antigen-binding factor.

1984 • 82 citations

Murine B1 B Cells Require IL-5 for Optimal T Cell-Dependent Activation

2001 • 76 citations

The Effect of Locally Injected Vasoactive Amines on the Elicitation of Delayed-Type Hypersensitivity

1977 • 70 citations

Yes T cells, but three different T cells (αβ,γδand NK T cells), and also B-1 cells mediate contact sensitivity

2001 • 70 citations

Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine.

1991 • 59 citations

Delayed-type hypersensitivity initiation by early-acting cells that are antigen mismatched or MHC incompatible with late-acting, delayed-type hypersensitivity effector T cells.

1991 • 53 citations

Free Hapten Molecules are Dispersed by Way of the Bloodstream During Contact Sensitization to Fluorescein Isothiocyanate

1999 • 41 citations

DNFB Contact Sensitivity (CS) In BALB/c and C3H/He Mice: Requirement for Early-Occurring, Early-Acting, Antigen-Specific, CS-Initiating Cells with an Unusual Phenotype (Thy-1+, CD5+, CD3-, CD4-, CD8-, sIg-, B220+, MHC Class II-, CD23+, IL-2R-, IL-3R+, Mel-14-, Pgp-1+, J11d+, MAC-1+, LFA-1+, and FcγRII+

1994 • 19 citations

Elicitation of Nickel Sulfate (NiSO4)-Specific Delayed-Type Hypersensitivity Requires Early-Occurring and Early-Acting, NiSO4-Specific DTH-Initiating Cells with an Unusual Mixed Phenotype for an Antigen-Specific Cell

1995 • 17 citations

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