Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

1997 • 1,977 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

THE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and Glycolipids

1999 • 711 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

1995 • 569 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor.

1981 • 516 citations

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

1998 • 474 citations

CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

1998 • 445 citations

Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.

1994 • 408 citations

Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay

1999 • 404 citations

Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

1998 • 383 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes

1998 • 319 citations

Characterization of a monoclonal anti‐β₂‐microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens

1979 • 308 citations

Lymphokine-activated killer cells: lysis of fresh syngeneic natural killer-resistant murine tumor cells by lymphocytes cultured in interleukin 2.

1984 • 299 citations

Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.

1991 • 268 citations

Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide.

1999 • 264 citations

Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells.

1999 • 260 citations

NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance

2001 • 244 citations

Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.

1977 • 233 citations

Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with α-Galactosylceramide

1999 • 230 citations

Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells

2000 • 218 citations

Simultaneous Quantification of Six Human Cytokines in a Single Sample Using Microparticle-based Flow Cytometric Technology

1999 • 216 citations

CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant Vα24JαQ T Cell Receptor α Chains

1998 • 200 citations

Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy.

1998 • 184 citations

Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta.

1987 • 172 citations

Treatment of hepatic metastasis of the colon26 adenocarcinoma with an alpha-galactosylceramide, KRN7000.

1998 • 164 citations

TRAIL expression by activated human CD4+Valpha24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells

2001 • 158 citations

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

1999 • 151 citations

Analysis of Human Vα24+ CD4+ NKT Cells Activated by α-Glycosylceramide-Pulsed Monocyte-Derived Dendritic Cells

2000 • 145 citations

A High-Titer Lentiviral Production System Mediates Efficient Transduction of Differentiated Cells Including Beating Cardiac Myocytes

1999 • 143 citations

Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells.

1998 • 138 citations

Cutting Edge: Structural Requirements for Galactosylceramide Recognition by CD1-Restricted NK T Cells

1998 • 121 citations

Human invariant Vα24⁺ natural killer T cells activated by α‐galactosylceramide (KRN7000) have cytotoxic anti‐tumour activity through mechanisms distinct from T cells and natural killer cells

2000 • 114 citations

Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells

2000 • 109 citations

Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes.

1985 • 102 citations

Flow microsphere immunoassay for the quantitative and simultaneous detection of multiple soluble analytes.

1990 • 87 citations

Antitumor Activity of α-Galactosylceramide, KRN7000, in Mice With the Melanoma B16 Hepatic Metastasis and Immunohistological Study of Tumor Infiltrating Cells

2001 • 70 citations

CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of Vα24JαQ T Cells: A Feedback Mechanism for Immune Regulation

2000 • 69 citations

Diverse CD1d-restricted reactivity patterns of human T cells bearing “invariant” AV24BV11 TCR

1998 • 68 citations

A novel recognition motif of human NKT antigen receptor for a glycolipid ligand

1999 • 67 citations

Regulation of human natural killer cell activity by interferon-gamma: lack of a role in interleukin 2-mediated augmentation.

1986 • 57 citations

Antigen-presenting function of mouse CD 1: one molecule with two different kinds of antigenic ligands

1998 • 53 citations

T-lymphocyte functionality assessed by analysis of cytokine receptor expression, intracellular cytokine expression, and femtomolar detection of cytokine secretion by quantitative flow cytometry

1998 • 51 citations

α-Glycosylceramides Enhance the Antitumor Cytotoxicity of Hepatic Lymphocytes Obtained from Cancer Patients by Activating CD3−CD56+ NK Cells In Vitro

2000 • 50 citations

Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production.

1998 • 49 citations

The identification of the β₂‐microglobulin binding antigen encoded by the human CDID gene

1991 • 44 citations

Chapter 33 Flow Microsphere Immunoassay for the Quantitative and Simultaneous Detection of Multiple Soluble Analytes

1994 • 44 citations

A fluorescence digital image microscopy system for quantifying relative cell numbers in tissue culture plates

1996 • 40 citations

Neutrophils are cytotoxic and growth-inhibiting for neuroblastoma cells with an anti-GD2 antibody but, without cytotoxicity, can be growth-stimulating

2000 • 35 citations

Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells.

2000 • 29 citations

Recombinant interferons or interleukin-2 increase cytotoxicity by human monocytes and NK cells.

1987 • 22 citations

Activation-induced expression of CD1d antigen on mature T cells

2001 • 20 citations

Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production.

1991 • 19 citations

Trafficking and activation of murine natural killer cells: Differing roles for IFN-γ and IL-2

1990 • 18 citations

Antigen-specific regulation of CD1 expression in humans.

2000 • 16 citations

In Vitro Induction of Lymphokine-Activated Killer (Lak) Activity in Patients with Neuroblastoma

1989 • 12 citations

A Single Cell Analysis of TCR AV24AJ18⁺ DN T Cells

1999 • 8 citations

Multiple Color Immunofluorescence for Cytokine Detection at the Single Cell Level

2003 • 5 citations