Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1995 • 620 citations

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

1995 • 572 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.

1994 • 418 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

The Molecular Basis of Blood Diseases

1994 • 370 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse Genome

1997 • 325 citations

The world according to Maf

1997 • 285 citations

Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

1997 • 240 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

Nuclear scaffold attachment sites in the human globin gene complexes.

1988 • 225 citations

Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

1995 • 217 citations

Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles

1998 • 209 citations

Human globin locus activation region (LAR): role in temporal control

1990 • 189 citations

A space-efficient algorithm for local similarities

1990 • 182 citations

Analysis of Mice Containing a Targeted Deletion of β-Globin Locus Control Region 5′ Hypersensitive Site 3

1996 • 179 citations

Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.

1992 • 165 citations

Regulation of β-globin gene expression: straightening out the locus

1996 • 146 citations

Regulation of Globin Gene Expression in Erythroid Cells

1995 • 143 citations

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.

1992 • 117 citations

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

1994 • 108 citations

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.

1985 • 106 citations

An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.

1993 • 105 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

Age-dependent silencing of globin transgenes in the mouse

1996 • 93 citations

The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice

1997 • 82 citations

A Globin Enhancer Acts by Increasing the Proportion of Erythrocytes Expressing a Linked Transgene

1997 • 77 citations

Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus.

1990 • 66 citations

The regulation of human globin gene switching

1993 • 62 citations

A 5′ β-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription

1994 • 62 citations

Recent Developments in Linear-Space Alignment Methods: A Survey

1994 • 62 citations

Role of DNA Sequences Outside the Cores of DNase Hypersensitive Sites (HSs) in Functions of the β-Globin Locus Control Region

1996 • 58 citations

Transcriptional control of globin gene switching during vertebrate development

1997 • 50 citations

Erythroid-specific nuclease-hypersensitive sites flanking the human beta-globin domain.

1990 • 48 citations

The mouse β-globin locus control region: hypersensitive sites 3 and 4

1992 • 43 citations

The Complete Sequences of the Galago and Rabbit β-Globin Locus Control Regions: Extended Sequence and Functional Conservation Outside the Cores of DNase Hypersensitive Sites

1997 • 31 citations

Positive and negative regulatory elements of the rabbit embryonic ϵ-globin gene revealed by an improved multiple alignment program and functional analysis

1993 • 26 citations

Appropriate developmental expression of human CD8 beta in transgenic mice.

1997 • 22 citations

Multiple nuclear factors interact with promoter sequences of the urokinase-type plasminogen activator gene

1988 • 21 citations