The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

New developments in biochemical mass spectrometry: electrospray ionization

1990 • 1,048 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

High Performance Liquid Cbromatographic Separation of Globin Chains on a Large-Pore C₄Column

1984 • 422 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.

1993 • 234 citations

A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

1996 • 220 citations

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.

1992 • 218 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

1995 • 190 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.

1993 • 141 citations

Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers.

1993 • 126 citations

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.

1995 • 118 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.

1996 • 109 citations

Subunit assembly of hemoglobin: an important determinant of hematologic phenotype

1987 • 104 citations

Electrostatic interactions in the assembly of haemoglobin

1983 • 86 citations

Developmental Regulation of Human Globin Genes in Transgenic Mice

1985 • 74 citations

Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region

1994 • 56 citations

Relationship of resistance to oxygen free radicals to CuZn‐superoxide dismutase activity in transgenic, transfected, and trisomic cells

1992 • 53 citations

Expediting Rare Variant Hemoglobin Characterization by Combined HPLC/Electrospray Mass Spectrometry

1993 • 50 citations

Physical mapping of yeast artificial chromosomes containing sequences from the human β-globin gene region

1991 • 40 citations

The mapping of transgenes by fluorescence in situ hybridization on G-banded mouse chromosomes

1994 • 32 citations

Mass Spectrometry in the Characterization of Variant Hemoglobins

1994 • 26 citations