Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System

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1983 • 11,902 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

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1985 • 1,248 citations

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1978 • 1,055 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Interferons and other regulatory cytokines

1989 • 306 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Regulation of cell proliferation and differentiation by interferons

1985 • 241 citations

R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1)

1990 • 234 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

The glucocorticoid receptor

1991 • 208 citations

Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1991 • 201 citations

BK Viral Enhancer Element and a Human Cellular Homolog

1983 • 175 citations

Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes

1990 • 158 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

Involvement of acis-element that binds an H2TF-l/NFxB like factor(s) in the virus-induced interferon-β gene expression

1989 • 118 citations

Improved mammalian vectors for high expression of G418 resistance.

1987 • 117 citations

Cytokine Gene Regulation: Regulatory cis-Elements and DNA Binding Factors Involved in the Interferon System

1992 • 87 citations

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.

1991 • 86 citations

The human interleukin-2 receptor β-chain gene: genomic organization, promoter analysis and chromosomal assignment

1990 • 85 citations

pSV00CAT: low background CAT plasmid

1988 • 75 citations

Sequence of a cDNA coding for human IRF-1

1989 • 74 citations

Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization

1990 • 65 citations

Identification of novel factors that bind to the PRD I region of the human β-interferon promoter

1992 • 64 citations

A Physical Map of 15 Loci on Human Chromosome 5q23-q33 by Two-Color Fluorescence in Situ Hybridization

1993 • 61 citations

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

1989 • 60 citations

Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23–q31

1991 • 46 citations

Sequence of a cDNA coding for human IRF-2

1989 • 40 citations

Characterization of the DNA binding domain of the mouse IRF-2 protein

1993 • 19 citations

Human Interferon Regulatory Factor 1: Intron-Exon Organization

1992 • 16 citations