Mutant p53 Tumor Suppressor Alleles Release ras-Induced Cell Cycle Growth Arrest

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

ras GENES

1987 • 3,818 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens

1980 • 430 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1985 • 334 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

1988 • 220 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

SV40-53K antigen: A possible role for 53K in normal cells

1981 • 187 citations

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

1986 • 168 citations

Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.

1987 • 163 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene.

1988 • 136 citations

Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells

1987 • 109 citations

Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents

1981 • 100 citations

Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation.

1987 • 97 citations

Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblasts

1985 • 74 citations

Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line

1988 • 62 citations

The cellular tumour antigen p53: Evidence for transformation-related, immunological variants of p53

1986 • 32 citations

Expression of Wild-Type p53 Is Not Compatible with - Continued Growth of p53-Negative Tumor Cells

1991 • 27 citations

Tumorigenicity of Fibroblast Lines Expressing the Adenovirus E1a, Cellular p53, or Normal c-myc Genes

1986 • 19 citations

Abelson Murine Leukemia Virus-Transformed Cells That Lack p53 Protein Synthesis Express Aberrant p53 mRNA Species

1984 • 15 citations