Tumorigenicity of Fibroblast Lines Expressing the Adenovirus E1a, Cellular p53, or Normal c-myc Genes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels

1979 • 564 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

1979 • 491 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

1983 • 436 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

The roles of individual polyoma virus early proteins in oncogenic transformation

1982 • 366 citations

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma

1983 • 286 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.

1983 • 240 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

A single gene and a pseudogene for the cellular tumour antigen p53

1983 • 208 citations

Nucleotide sequence comparison of normal and translocated murine c-myc genes

1984 • 154 citations

Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture.

1984 • 132 citations

New Method for Detecting Cellular Transforming Genes

1982 • 131 citations

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

1982 • 126 citations

Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector

1984 • 121 citations

Transcriptional activation of the translocated c-myc oncogene in mouse plasmacytomas: Similar RNA levels in tumor and proliferating normal cells

1984 • 116 citations

Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.

1984 • 111 citations

Structure and Function of the Transforming Genes of Human Adenoviruses and SV40

1980 • 108 citations

Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation

1983 • 100 citations

Incomplete transformation of rat cells by a small fragment of adenovirus 12 DNA

1979 • 82 citations

Adenovirus type 2 early proteins: Assignment of the early region 1A proteins synthesized in vivo and in vitro to specific mRNAs

1981 • 81 citations

Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1A

1983 • 53 citations