Trophic factors

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

1994 • 635 citations

Disruption of the CNTF gene results in motor neuron degeneration

1993 • 566 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Nerve growth factor and nociception

1993 • 530 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

A crucial role for neurotrophin-3 in oligodendrocyte development

1994 • 353 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Dopaminergic neurons in rat ventral midbrain express brain‐derived neurotrophic factor and neurotrophin‐3 mRNAs

1994 • 290 citations

Fibroblasts Genetically Modified to Produce Nerve Growth Factor Induce Robust Neuritic Ingrowth after Grafting to the Spinal Cord

1994 • 287 citations

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

1994 • 285 citations

Sympathetic neuroblasts undergo a developmental switch in trophic dependence

1993 • 279 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

1994 • 268 citations

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

1993 • 259 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Coexpression of neurotrophins and their receptors in neurons of the central nervous system.

1993 • 242 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

1993 • 230 citations

NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival

1993 • 218 citations

Regulation of neurotrophin receptor expression during embryonic and postnatal development

1994 • 208 citations

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

1994 • 207 citations

Tissue-specific alternative splicing generates two isoforms of the trkA receptor

1993 • 206 citations

Influences of neurotrophins on mammalian motoneurons in vivo

1993 • 205 citations

A null mutation in the human CNTF gene is not causally related to neurological diseases

1994 • 202 citations

Dependence on p75 for Innervation of Some Sympathetic Targets

1994 • 199 citations

Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival

1992 • 195 citations

A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

1991 • 193 citations

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

1993 • 177 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 164 citations

Neurotrophic Factor Receptors and Their Signal Transduction Capabilities in Rat Astrocytes

1994 • 164 citations

Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats

1992 • 162 citations

Intrinsic programmes of growth and survival in developing vertebrate neurons

1994 • 139 citations

Nerve Growth Factor Facilitates Regeneration across Nerve Gaps: Morphological and Behavioral Studies in Rat Sciatic Nerve

1993 • 135 citations

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

1993 • 135 citations

Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.

1993 • 130 citations

Transplantation of a Polymer-Encapsulated Cell Line Genetically Engineered to Release NGF

1993 • 129 citations

HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding

1993 • 127 citations

Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts

1993 • 121 citations

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.

1994 • 120 citations

Highly selective effects of nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3 on intact and injured basal forebrain magnocellular neurons

1994 • 117 citations

Peripheral nerve injury

1994 • 111 citations

Peripheral nerve regeneration: Role of growth factors and their receptors

1993 • 110 citations

Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues

1993 • 106 citations

Further characterization of the effects of brain‐derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons

1994 • 99 citations

Neurotrophic Factors: Switching neurotrophin dependence

1994 • 96 citations

Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration

1994 • 95 citations

Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture

1993 • 90 citations

Rapid Phosphorylation of Phospholipase Cγ 1 by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Cultures of Embryonic Rat Cortical Neurons

1993 • 83 citations

Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection

1993 • 80 citations

Rabbit facial nerve regeneration in NGF‐containing silastic tubes

1993 • 65 citations

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

1994 • 60 citations

BDNF protection of basal forebrain cholinergic neurons after axotomy

1993 • 60 citations

Brain‐derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5‐trihydroxyphenylalanine‐induced injury

1993 • 52 citations

Microencapsulated nerve growth factor: Effects on the forebrain neurons following devascularizing cortical lesions

1992 • 50 citations

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats

1994 • 43 citations

Neurotrophic factor receptors: just like other growth factor and cytokine receptors?

1994 • 33 citations

Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons

1993 • 32 citations

Postnatal gene transfer into the central nervous system

1993 • 13 citations