Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

1983 • 2,305 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Cholinergic systems in mammalian brain and spinal cord

1991 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The organization and some projections of cholinergic neurons of the mammalian forebrain

1982 • 821 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease

1992 • 618 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system

1983 • 461 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

1992 • 371 citations

Tacrine in Alzheimer's disease

1991 • 355 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

1992 • 281 citations

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

1990 • 278 citations

Nerve growth factor promotes cholinergic development in brain striatal cultures.

1985 • 245 citations

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat

1989 • 243 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

1988 • 233 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

1994 • 207 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

The Biological Substrates of Alzheimerʼs Disease

1987 • 180 citations

Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease

1989 • 168 citations

The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration

1987 • 161 citations

BDNF AND NGF TREATMENT IN LESIONED RATS

1992 • 156 citations

Cholinergic neurons in the rat central nervous system demonstrated by in situ hybridization of choline acetyltransferase mRNA

1992 • 139 citations

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

1988 • 134 citations

Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus

1992 • 122 citations

NGF effects on developing forebrain cholinergic neurons are regionally specific

1987 • 120 citations

Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain

1991 • 107 citations

Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat

1991 • 106 citations

Receptor‐mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors

1991 • 96 citations

Basal forebrain cell loss following fimbria/fornix transection

1990 • 93 citations

Primary Structure and Biological Activity of Human Brain-Derived Neurotrophic Factor

1991 • 87 citations

Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: Evidence from lesion and chronic cholinergic drug treatment studies

1993 • 83 citations

Differential regulation of the low‐affinity nerve growth factor receptor during postnatal development of the rat brain

1991 • 81 citations

Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons

1990 • 78 citations

Acute and chronic effects of oral physostigmine and lecithin in Alzheimer's disease

1986 • 75 citations

Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study.

1992 • 75 citations

Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septohippocampal lesions: Measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferase activity

1991 • 74 citations

Nerve growth factor effects on cholinergic neurons of neostriatum and nucleus accumbens in the adult rat

1989 • 71 citations

Axotomy-dependent stimulation of choline acetyltransferase activity by exogenous mouse nerve growth factor in adult rat basal forebrain

1989 • 67 citations

Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway

1990 • 66 citations

Recombinant human nerve growth factor is biologically active and labels novel high-affinity binding sites in rat brain.

1991 • 64 citations

Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway

1991 • 62 citations

Distribution of β‐nerve growth factor receptors in the human basal forebrain

1989 • 48 citations

Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells

1990 • 47 citations

Distribution and characteristics of nerve growth factor binding on cholinergic neurons of rat and monkey forebrain

1987 • 42 citations

Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain

1992 • 40 citations

Combined in situ hybridization and immunocytochemistry in the assay of pharmacological effects on tyrosine hydroxylase mRNA concentration

1989 • 33 citations

Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections

1992 • 22 citations