Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Developmental Neurobiology

1978 • 1,211 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer

1972 • 914 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

1991 • 578 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

1990 • 365 citations

Function and evolution in the NGF family and its receptors

1992 • 338 citations

Molecular Cloning and Expression of Rat Interleukin-1α cDNA

1989 • 332 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

1992 • 281 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Expression of highly polysialylated NCAM in the neocortex and piriform cortex of the developing and the adult rat

1991 • 257 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Widespread and Developmentally Regulated Expression of Neurotrophin‐4 mRNA in Rat Brain and Peripheral Tissues

1993 • 256 citations

Nerve growth factor promotes cholinergic development in brain striatal cultures.

1985 • 245 citations

Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

1992 • 243 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons

1992 • 240 citations

Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system

1992 • 204 citations

A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

1991 • 193 citations

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1991 • 190 citations

Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

1992 • 174 citations

Expression of members of the trk family in the developing postnatal rat brain

1993 • 174 citations

Mapping the development of the rat brain by GAP-43 immunocytochemistry

1991 • 171 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Differential expression of the nerve growth factor receptor gene in multiple brain areas

1988 • 146 citations

Cell migration in the rat embryonic neocortex

1991 • 145 citations

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

1993 • 135 citations

Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord.

1992 • 131 citations

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.

1992 • 127 citations

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

1988 • 122 citations

Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain

1991 • 107 citations

Phosphorylation of Nek in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP

1992 • 94 citations

Rapid Phosphorylation of Phospholipase Cγ 1 by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Cultures of Embryonic Rat Cortical Neurons

1993 • 83 citations

Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C γ1

1991 • 67 citations

Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

1991 • 62 citations

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.

1992 • 55 citations

Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells

1990 • 47 citations

Characterization of neurotrophin receptors by affinity crosslinking

1993 • 43 citations

Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons

1992 • 40 citations

Stimulation of Phosphatidylinositol Hydrolysis by Brain-Derived Neurotrophic Factor and Neurotrophin-3 in Rat Cerebral Cortical Neurons Developing in Culture

1992 • 40 citations

Location of a transiently expressed glycoprotein in developing cerebellum delineating its possible ontogenetic roles

1989 • 37 citations

SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells

1993 • 36 citations

Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain.

1993 • 20 citations

Localization of nerve growth factor receptor mRNA in the rat basal forebrain within situ hybridization histochemistry

1990 • 19 citations