Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

There is more than one interleukin 1

1986 • 1,226 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Tumor Necrosis Factors: Gene Structure and Biological Activities

1986 • 215 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

1989 • 176 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

Tumor Necrosis Factor Induces the Rapid Phosphorylation of the Mammalian Heat Shock Protein hsp28

1990 • 125 citations

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.

1990 • 117 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Tumor Necrosis Factor Signal Transduction

1989 • 114 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Cyclic AMP and interleukin 1 signal transduction

1990 • 107 citations

IL-1 activates two separate signal transduction pathways in T helper type II cells.

1990 • 101 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

An Early Event in the Interferon-Induced Transmembrane Signaling Process

1986 • 91 citations

Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?

1989 • 87 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

IL-1 induces rapid phosphorylation of the IL-1 receptor.

1989 • 74 citations

Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.

1990 • 69 citations

Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.

1989 • 65 citations

Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

1989 • 58 citations

Phosphorylation of a cytosolic 65-kDa protein induced by interleukin 1 in glucocorticoid pretreated normal human peripheral blood mononuclear leukocytes.

1987 • 58 citations

IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.

1988 • 54 citations

α-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts

1986 • 54 citations

Interleukin-one induced inositol phospholipid breakdown in murine macrophages: Possible mechanism of receptor activation

1988 • 42 citations

Characterization of interleukin 2-stimulated 65-kilodalton phosphoprotein in human T cells

1990 • 36 citations

A STUDY OF THE EFFECTS OF CATABOLIN ON CYCLIC ADENOSINE MONOPHOSPHATE BIOSYNTHESIS AND PROSTAGLANDIN E2 SECRETION IN PIG ARTICULAR CHONDROCYTES

1986 • 22 citations

Recombinant human tumour necrosis factor increases cytosolic free calcium in murine fibroblasts and stimulates inositol phosphate formation in L-M and arachidonic acid release in 3T3 cells

1990 • 21 citations

The use of cells doubly labelled with [14C]inositol and [3H]inositol to search for a hormone-sensitive inositol lipid pool with atypically rapid metabolic turnover

1989 • 18 citations

Interleukin-1 induces a pertussis toxin-sensitive increase in diacylglycerol accumulation in mouse thymoma cells.

1989 • 15 citations

Lymphokine signal transduction

1990 • 8 citations

Nuclear proteins from the rat pituitary gland bind to regulatory sequences of the thyrotrophin-β gene

1989 • 3 citations