Accelerated apoptosis in the Timp-3–deficient mammary gland

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 • 731 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

1994 • 660 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

2001 • 493 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

1998 • 468 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase

2000 • 409 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

Matrix Survival Signaling

2000 • 360 citations

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

1996 • 333 citations

TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix

2000 • 323 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

1999 • 285 citations

The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form

1998 • 228 citations

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

2001 • 225 citations

Inhibition of Late Vein Graft Neointima Formation in Human and Porcine Models by Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-3

2000 • 208 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

Cellular Turnover in the Mammary Gland Is Correlated with Systemic Levels of Progesterone and Not 17β-Estradiol During the Estrous Cycle1

2001 • 192 citations

TIMP-3 INDUCES CELL DEATH BY STABILIZING TNF-α RECEPTORS ON THE SURFACE OF HUMAN COLON CARCINOMA CELLS

1997 • 190 citations

Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)

1996 • 182 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.

1992 • 173 citations

Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors

2000 • 148 citations

Control of milk secretion and apoptosis during mammary involution.

1999 • 148 citations

Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3

1996 • 146 citations

Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis

1996 • 146 citations

Tissue Inhibitor of Metalloproteinases-3 Inhibits Shedding of L-selectin from Leukocytes

1999 • 126 citations

Localization of the Death Domain of Tissue Inhibitor of Metalloproteinase-3 to the N Terminus

2000 • 123 citations

Adamalysins: A Family of Metzincins Including TNF‐α Converting Enzyme (TACE)

1999 • 118 citations

Human Tissue Inhibitor of Metalloproteinases 3 Interacts with Both the N- and C-terminal Domains of Gelatinases A and B

1999 • 116 citations

Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development

1999 • 114 citations

Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1

1999 • 106 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2001 • 105 citations

INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS

1999 • 100 citations

Roles of Fas and Fas ligand during mammary gland remodeling

2000 • 97 citations

Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

1998 • 94 citations

Oocyte attrition

2000 • 88 citations

Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling

2000 • 87 citations

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.

1998 • 86 citations

Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland.

1992 • 77 citations

Topographical arrangement of basement membrane proteins in lactating rat mammary gland: comparison of the distribution of type IV collagen, laminin, fibronectin, and Thy-1 at the ultrastructural level.

1983 • 75 citations

Transcriptional inactivation of the tissue inhibitor of metalloproteinase-3 gene by dna hypermethylation of the 5'-CpG island in human gastric cancer cell lines

2000 • 67 citations

Mutations in the Heparin Binding Domain of Fibronectin in Cooperation with the V Region Induce Decreases in pp125 Levels Plus Proteoglycan-mediated Apoptosis via Caspases

1999 • 59 citations

Full-Length and N-TIMP-3 Display Equal Inhibitory Activities toward TNF-α Convertase

2001 • 59 citations

Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts

1983 • 50 citations

Matrix metalloproteinases and their expression in mammary gland

1998 • 49 citations

Tumor necrosis factor-alpha: a multifunctional regulator of mammary gland development

1996 • 21 citations

Lactation Stage‐Dependent Changes in Levels of Tumor Necrosis Factor/Cachectin in Milk

1994 • 17 citations