Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

1984 • 540 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus

1979 • 243 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

1986 • 136 citations

DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.

1982 • 113 citations

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1984 • 110 citations

Communication between segments of DNA during site-specific recombination

1987 • 107 citations

Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement.

1985 • 89 citations

A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanism

1983 • 86 citations

Recombined flanks of the variable and joining segments of immunoglobulin genes.

1982 • 83 citations

Common Mechanism of Chromosome Inversion in B- and T-Cell Tumors: Relevance to Lymphoid Development

1986 • 77 citations

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

1984 • 77 citations

Transformation of Immature Lymphoid Cells by Abelson Murine Leukemia Virus

1979 • 77 citations

A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments

1980 • 75 citations

Molecular Cloning of Polyoma Virus DNA in Escherichia coli : Plasmid Vector System

1979 • 69 citations

Expression of an immunoglobulin heavy chain gene transfected into lymphocytes.

1984 • 53 citations

Immunoglobulin gene ‘remnant’ DNA - implications for antibody gene recombination

1984 • 44 citations