Nitric oxide.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Beyond Cholesterol

1989 • 6,533 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients

1989 • 1,003 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

1990 • 854 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Enzyme-independent formation of nitric oxide in biological tissues

1995 • 783 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Selective Sparing of a Class of Striatal Neurons in Huntington's Disease

1985 • 767 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

1992 • 740 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

1991 • 627 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION

1989 • 589 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Modulation of acute inflammation by endogenous nitric oxide

1992 • 543 citations

Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

1993 • 540 citations

Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

1991 • 538 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

<scp>l</scp>‐N^G‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse

1991 • 481 citations

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

1994 • 477 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin

1990 • 474 citations

Nitric oxide synthase activity in ulcerative colitis and Crohn's disease

1993 • 468 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat

1990 • 454 citations

L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.

1991 • 450 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Arginine enhances wound healing and lymphocyte immune responses in humans.

1990 • 446 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

1993 • 397 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?

1992 • 385 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Leukocyte adherence to venular endothelium during ischemia-reperfusion

1989 • 381 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

1994 • 374 citations

Modulation of Airway Epithelial Cell Ciliary Beat Frequency by Nitric Oxide

1993 • 373 citations

Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms.

1994 • 372 citations

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

1994 • 369 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Nitric Oxide Synthase Activity in Infantile Hypertrophic Pyloric Stenosis

1992 • 353 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.

1993 • 352 citations

Increased nitric oxide synthesis in ulcerative colitis

1993 • 347 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain.

1993 • 339 citations

Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.

1991 • 331 citations

Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease.

1989 • 328 citations

Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway

1990 • 326 citations

Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells

1993 • 325 citations

Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.

1991 • 321 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

The effects of L‐arginine and N^G‐monomethyl L‐arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation

1989 • 313 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

1991 • 311 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.

1991 • 307 citations

Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat

1992 • 298 citations

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

1993 • 294 citations

HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT

1989 • 290 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Synergism between tumor necrosis factor‐α and interferon‐γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide‐dependent mechanism

1992 • 290 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Induction of Nitric Oxide Synthase in Human Chondrocytes

1993 • 286 citations

Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure

1991 • 286 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.

1993 • 255 citations

The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation

1989 • 254 citations

Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo

1989 • 250 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

Purification of nitric oxide synthase from rat macrophages

1991 • 244 citations

Inhibition of nitric oxide synthesis impairs two different forms of learning

1992 • 240 citations

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

1989 • 238 citations

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

1992 • 237 citations

Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

1992 • 233 citations

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

1990 • 230 citations

Nitric oxide controls oscillatory activity in thalamocortical neurons

1992 • 227 citations

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

1993 • 223 citations

Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach

1989 • 219 citations

Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter

1991 • 218 citations

Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum

1990 • 218 citations

Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo

1990 • 211 citations

Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase.

1994 • 207 citations

Evidence that endogenous nitric oxide modulates oedema formation induced by substance P

1990 • 201 citations

Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.

1992 • 200 citations

Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs.

1991 • 199 citations

Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor

1989 • 198 citations

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption.

1994 • 198 citations

Regulation of nitric oxide synthase by nitric oxide.

1993 • 197 citations

Cellular Origins of Cyclic GMP Responses to Excitatory Amino Acid Receptor Agonists in Rat Cerebellum In Vitro

1987 • 196 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils

1991 • 195 citations

Inhibition by nitric oxide of the repair protein, O⁶-DNA-methyltransferase

1994 • 195 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

EVIDENCE FOR A ROLE OF NITRIC OXIDE IN THE NEUROTRANSMITTER SYSTEM MEDIATING RELAXATION OF THE RAT ANOCOCCYGEUS MUSCLEC

1989 • 190 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction

1990 • 185 citations

Cytokines and Free Radicals as Effector Molecules in the Destruction of Pancreatic Beta Cells

1990 • 185 citations

Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta

1990 • 183 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

NG-Nitro-L-arginine prevents morphine tolerance

1992 • 183 citations

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

1993 • 180 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Immunosuppression induced by nitric oxide and its inhibition by interleukin‐4

1992 • 172 citations

Endothelium-derived Relaxing Factor Inhibits Hypoxic Pulmonary Vasoconstriction in Rats

1991 • 169 citations

Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP

1989 • 149 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways

1991 • 146 citations

Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide

1992 • 144 citations

Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: Stimulation of guanylate cyclase and inhibition of platelet aggregation

1990 • 143 citations

Possible central role of nitric oxide in conditions clinically similar to cerebral malaria

1992 • 140 citations

Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover

1983 • 140 citations

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

1992 • 136 citations

Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat

1992 • 133 citations

Plasma nitric oxide levels in newborn infants with sepsis

1993 • 133 citations

Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.

1990 • 131 citations

Impairment of pulmonary endothelium‐dependent relaxation in patients with Eisenmenger's syndrome

1990 • 130 citations

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

1992 • 130 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages

1992 • 117 citations

Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5?-diphosphate and bradykinin

1992 • 116 citations

Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries.

1990 • 110 citations

Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism.

1991 • 108 citations

Cytokines Induce Nitric Oxide Production in Mouse Osteoblasts

1994 • 105 citations

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1992 • 103 citations

Nitric Oxide Release in Response to Gut Injury

1993 • 102 citations

Synthesis of nitric oxide in the bovine retina

1991 • 102 citations

Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.

1992 • 100 citations

Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release.

1993 • 95 citations

Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine.

1992 • 94 citations

Stimulation of lymphocyte natural cytotoxicity by L-arginine

1991 • 93 citations

Localization of cGMP in the cerebellum of the adult rat: an immunohistochemical study

1989 • 92 citations

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1991 • 91 citations

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.

1993 • 89 citations

Nitric oxide as a putative nonadrenergic noncholinergic inhibitory transmitter in the canine pylorus in vivo

1992 • 89 citations

Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid.

1990 • 89 citations

Free radical yields from the homolysis of peroxynitrous acid

1992 • 86 citations

Nitric oxide generation from L-arginine is required for optimal human peripheral blood lymphocyte DNA synthesis.

1991 • 84 citations

Sustained hypertension induced by orally administered nitro-L-arginine.

1993 • 81 citations

Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes

1992 • 80 citations

<scp>l</scp>‐Leucyl‐<scp>l</scp>‐arginine, naltrindole and <scp>d</scp>‐arginine block antinociception elicited by <scp>l</scp>‐arginine in mice with carrageenin‐induced hyperalgesia

1992 • 80 citations

Localization of brain nitric oxide synthase (NOS) to human chromosome 12

1992 • 77 citations

Role of endothelium‐derived nitric oxide in the regulation of tonus in large‐bore arterial resistance vessels, arterioles and veins in cat skeletal muscle

1990 • 76 citations

EVIDENCE THAT NITRIC OXIDE PRODUCTION BY IN VIVO ALLOSENSITIZED CELLS INHIBITS THE DEVELOPMENT OF ALLOSPECIFIC CTL

1992 • 75 citations

Antinociceptive effect of L-arginine on the carrageenin-induced hyperalgesia of the rat: possible involvement of central opioidergic systems

1992 • 73 citations

Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.

1993 • 71 citations

Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism.

1991 • 71 citations

Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils

1992 • 68 citations

A new approach in the treatment of hypotension in human septic shock by NG-monomethyl-L-arginine, an inhibitor of the nitric oxide synthetase

1993 • 67 citations

Cloned murine T lymphocytes synthesize a molecule with the biological characteristics of nitric oxide

1990 • 66 citations

Soluble guanylate cyclase activation by nitric oxide and its reversal

1983 • 65 citations

Localization of the Human Gene for Inducible Nitric Oxide Synthase (NOS2) to Chromosome 17q11.2-q12

1994 • 64 citations

Bronchodilator effect of inhaled nitric oxide in healthy men.

1994 • 60 citations

Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa

1990 • 60 citations

Reduction of striatal N-methyl-d-aspartate toxicity by inhibition of nitric oxide synthase

1993 • 59 citations

A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages

1992 • 56 citations

The pathogenesis of rheumatoid arthritis

1959 • 52 citations

Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries

1989 • 49 citations

Nitric oxide is inactivated by the bacterial pigment pyocyanin.

1990 • 48 citations

The quantitative contribution of nitric oxide and sensory nerves to bradykinin-induced inflammation in rat skin microvasculature

1992 • 47 citations

Co-purification of 130 KD nitric oxide synthase and A 22 KD link protein from human neutrophils

1992 • 44 citations

Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an l-arginine-dependent process

1991 • 40 citations

Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection and graft-versus-host disease after small-bowel transplantation in the rat.

1992 • 39 citations

Staphylococcal exotoxins stimulate nitric oxide-dependent murine macrophage tumoricidal activity

1991 • 38 citations

Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma-stimulated macrophages.

1994 • 36 citations

Nitric oxide modulates sympathetic vasoconstriction and basal blood flow in normal and acutely inflamed rabbit knee joints

1993 • 35 citations

Potentiation of aspirin-induced gastric lesions by exposure to cold in rats

1989 • 34 citations

Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein

1990 • 33 citations

Exercise induced release of von Willebrand factor: evidence for hypoxic reperfusion microvascular injury in rheumatoid arthritis.

1992 • 28 citations

Cyclosporin A protects pancreatic islet cells from nitric oxide‐dependent macrophage cytotoxicity

1992 • 25 citations

Deficient production of nitric oxide induces volume-dependent hypertension

1992 • 18 citations

T-cell mitogenic responses in fully xenogeneic chimeras (WF rat----B10 mouse) are restored by blocking the L-arginine-dependent nitric oxide pathway.

1992 • 2 citations