Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

1992 • 283 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

1991 • 148 citations

Interleukin 1 is Potent Modulator of Insulin Secretion from Isolated Rat Islets of Langerhans

1987 • 145 citations

Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation

1992 • 142 citations

Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction

1992 • 140 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

Interaction of β-Cell Activity and IL-1 Concentration and Exposure Time in Isolated Rat Islets of Langerhans

1989 • 129 citations

L-Arginine Stimulates Cyclic Guanosine 3′,5′- Monophosphate Formation in Rat Islets of Langerhans and RINm5F Insulinoma Cells: Evidence for LArgininerNitric Oxide Synthase*

1991 • 122 citations

Purification and characterization of a human NO synthase

1991 • 115 citations

Nitric oxide production by monocytes in alcoholic liver disease

1992 • 102 citations

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

1987 • 92 citations

Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.

1985 • 87 citations

Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients.

1987 • 68 citations