Adenosine antagonists

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

1929 • 1,470 citations

The Pharmacological Basis of Therapeutics

1986 • 1,413 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Textbook of Pharmacology.

1980 • 857 citations

Adenosine receptors: targets for future drugs

1982 • 681 citations

How does adenosine inhibit transmitter release?

1988 • 649 citations

The Physiological Role of Adenosine In The Central Nervous System

1985 • 628 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Adenosine as a Neuromodulator

1985 • 462 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

Increased Anxiogenic Effects of Caffeine in Panic Disorders

1985 • 427 citations

Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine

1982 • 417 citations

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

1987 • 376 citations

Biochemical Evidence of Dysfunction of Brain Neurotransmitters in the Lesch-Nyhan Syndrome

1981 • 370 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Purine Receptors in Mammalian Tissues: Pharmacology and Functional Significance

1987 • 302 citations

Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 • 301 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3′,5′‐PHOSPHATE IN ISOLATED CEREBRAL TISSUE

1969 • 294 citations

Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor

1986 • 284 citations

Caffeine as an Analgesic Adjuvant

1984 • 258 citations

Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP

1978 • 246 citations

Is Adenosine an Endogenous Anticonvulsant?

1985 • 243 citations

Cardiovascular effects of adenosine in man; possible clinical implications

1986 • 227 citations

1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors

1985 • 223 citations

Brain adenosine production in the rat during 60 seconds of ischemia.

1979 • 213 citations

Methylxanthines in Apnea of Prematurity

1979 • 203 citations

Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists

1980 • 198 citations

CGS 8216: Receptor binding characteristics of a potent benzodiazepine antagonist

1982 • 192 citations

Purinergic mechanisms in epilepsy

1988 • 190 citations

CNS Dopamine Autoreceptors: Distribution, Pharmacology, and Function^a

1984 • 185 citations

Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.

1983 • 164 citations

Human Consumption of Caffeine

1984 • 164 citations

Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine.

1980 • 155 citations

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex

1978 • 154 citations

Xanthine derivatives as antagonists at A1 and A2 adenosine receptors

1985 • 150 citations

Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists

1988 • 147 citations

3,7-Dimethyl-1-propargylxanthine: A potent and selective in vivo antagonist of adenosine analogs

1988 • 141 citations

Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts

1981 • 137 citations

Adenosine Receptors Mediating Cyclic AMP Productioin the Rat Hippocampus

1982 • 137 citations

Purines : pharmacology and physiological roles

1985 • 134 citations

Analogs of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors

1986 • 121 citations

Molecular Genetic Neuroscience

1983 • 121 citations

In vivo bahavioral assessment of central nervous system purinergic receptors

1981 • 120 citations

Beyond receptors: Multiple second‐messenger systems in brain

1987 • 108 citations

On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat

1983 • 106 citations

Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.

1986 • 105 citations

Modulation of Striatal Dopaminergic Function by Local Injection of 5′- N -Ethylcarboxamide Adenosine

1982 • 104 citations

THE CHRONIC ORAL TOXICITY OF CAFFEINE

1965 • 100 citations

Coronary vasoactivity of adenosine in the conscious dog.

1979 • 99 citations

N6-Cycloalkyladenosines. Potent, A1-selective adenosine agonists

1985 • 98 citations

Stimulation of Release of Adrenal Catecholamine by Adenosine 3′:5′-Cyclic Monophosphate and Theophylline in the Absence of Extracellular Ca ²⁺

1972 • 97 citations

PD 115,199: An antagonist ligand for adenosine A2 receptors

1987 • 96 citations

Analogs of caffeine: Antagonists with selectivity for A2 adenosine receptors

1986 • 96 citations

Adenosine Analogues Depress Ventilation in Rabbit Neonates. Theophylline Stimulation of Respiration via Adenosine Receptors?

1984 • 93 citations

The Action of Adenosine Upon the Human Heart

1930 • 91 citations

Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease

1982 • 90 citations

[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors.

1986 • 85 citations

Caffeine induces a transient inward current in cultured cardiac cells

1983 • 82 citations

N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor

1988 • 81 citations

THE MECHANISM OF ACTION OF AMINOPHYLLINE UPON CEREBRAL VASCULAR DISORDERS

1970 • 79 citations

Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries

1988 • 72 citations

1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N-ethylcar☐amidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors

1986 • 71 citations

Nomenclature of adenosine receptors

1985 • 71 citations

Caffeine down-regulates β adrenoreceptors in rat forebrain

1982 • 69 citations

Possible role of adenosine in the macula densa mechanism of renin release in rabbits.

1985 • 69 citations

Adenosine — a selective neuromodulator in the mammalian CNS?

1984 • 68 citations

The role of adenosine in the regulation of glomerular filtration rate and renin secretion

1984 • 67 citations

Adenosine A1 receptors in mammalian brain: Species differences in their interactions with agonists and antagonists

1986 • 66 citations

Functionalized congeners of adenosine: preparation of analogs with high affinity for A1-adenosine receptors

1985 • 60 citations

Species differences in high‐affinity adenosine A₂ binding sites in striatal membranes from mammalian brain

1988 • 60 citations

Effects of acute administration of caffeine on local cerebral glucose utilization in the rat

1984 • 59 citations

Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application

1985 • 59 citations

The role of adenosine in the central actions of the benzodiazepines

1988 • 59 citations

Nutrition and behavior.

1981 • 59 citations

Nitrobenzylthioinosine binding in brain: An interspecies study

1985 • 58 citations

Accumulations of inositol phosphates and cyclic AMP in brain slices: Synergistic interactions of histamine and 2-chloroadenosine

1986 • 57 citations

Adenosine Receptors and Adenylate Cyclase Interactions

1983 • 57 citations

Adenosine antagonists as potential therapeutic agents

1988 • 57 citations

Adenosine and adenine nucleotides: Physiology and pharmacology

1989 • 55 citations

Molecular aspects of the action of benzodiazepine and nonbenzodiazepine anxiolytics: A hypothetical allosteric model of the benzodiazepine receptor complex

1984 • 52 citations

Interaction of putative anxiolytic agents with central adenosine receptors

1981 • 49 citations

Selective inhibitors of three forms of cyclic nucleotide phosphodiesterases

1984 • 48 citations

The effects of chronic lithium and ECT on A1 and A2 adenosine receptor systems in rat brain

1984 • 48 citations

8-Aryl- and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors

1988 • 47 citations

Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: Evaluation of structure-activity relationships

1982 • 47 citations

Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists

1987 • 47 citations

[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists

1988 • 46 citations

Benzodiazepine interaction with adenosine systems explains some anomalies in GABA hypothesis

1988 • 42 citations

Pyrazolo[3, 4-]pyrimidines as adenosine antagonists

1984 • 41 citations

Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat

1986 • 40 citations

A [³H]amine congener of 1,3‐dipropyl‐8‐phenylxanthine

1986 • 37 citations

Iodine-125-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors

1988 • 34 citations

Analogs of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents

1986 • 34 citations

Arachidonic acid metabolism in cultured aortic endothelial cells

1985 • 34 citations

Increase of [3H]clonidine binding sites induced by adenosine receptor agonists in rat vas deferens in vitro

1982 • 32 citations

Immunological Diseases.

1988 • 30 citations

The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat

1986 • 26 citations

Differences in adenosine A-1 and A-2 receptor density revealed by autoradiography in methylxanthine-sensitive and insensitive mice

1988 • 26 citations

Neurohumoral Control of Blood Vessels

1985 • 24 citations

Regulation of Atrioventricular Node Function by Adenosine

1987 • 21 citations

Adenosine receptor activation blocks seizures induced by bicuculline methiodide in the rat prepiriform cortex

1988 • 21 citations

The Negative Chronotropic Effect of Adenosine in Sinus Node Cells

1987 • 21 citations

Levels and Cardiovascular Effects of Adenosine in Humans

1987 • 21 citations

PACPX ‐ a substituted xanthine ‐ antagonizes both the A₁ and A₂ subclasses of the P₁‐purinoceptor: antagonism of the A₂ subclass is competitive but antagonism of the A₁ subclass is not

1985 • 19 citations

Nomenclature and classification of receptors and binding sites: The need for harmony

1987 • 18 citations

Purines

1985 • 16 citations

A preliminary investigation of “albert 285” (HWA 285) on psychomotor performance, mood, and memory

1985 • 16 citations

Biochemical characterization of the antagonist actions of the xanthines, PACPX (1,3-dipropyl-8(2-amino-4-chloro)phenylxanthine) and 8-PT (8-phenyltheophylline) at adenosine A1 and A2 receptors in rat brain tissue

1987 • 15 citations

The Bronchoconstrictor Activity of Adenosine in Asthma

1987 • 14 citations

Tolerance and some Circulatory Effects of Intravenous and Oral Enprofylline in Healthy Volunteers

1983 • 14 citations

Autoradiographic localization of adenosine A1 receptors in rat brain using [3H]XCC, a functionalized congener of 1,3-dipropylxanthine

1987 • 14 citations

The role of adenosine in cerebral vascular regulation during reductions in perfusion pressure

1986 • 14 citations

Antagonism of presynaptic adenosine receptors by theophylline 9-β-<scp>D</scp>-riboside and 8-phenyltheophylline

1981 • 12 citations

Interactions of Adenosine with other Agents

1983 • 12 citations

Interaction between 2-chloroadenosine and α-adrenoceptors in rat vas deferens

1984 • 9 citations

A caffeine analogue (1,3,7-trimethyl-6-thioxo-2-oxopurine) with a negative inotropic and chronotropic effect

1985 • 9 citations

Beobachtungen über die Wirkung des citronensauren Coffeïn's

1864 • 8 citations

Aminophylline shortens thiopental sleep-time and enhances noradrenergic neurotransmission in rats

1986 • 8 citations

Inhibition of antibody production by 2-chloroadenosine

1985 • 8 citations

Lack of effect of 1-methylisoguanosine on sleep in rats

1985 • 4 citations