Xanthine derivatives as antagonists at A1 and A2 adenosine receptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis

1964 • 1,401 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Adenosine receptors: targets for future drugs

1982 • 681 citations

The enzymatic preparation of [α-32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP

1979 • 574 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

PREPARATION AND CHARACTERIZATION OF A PLASMA MEMBRANE FRACTION FROM ISOLATED FAT CELLS

1970 • 402 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells

1978 • 251 citations

Xanthine derivatives as adenosine receptor antagonists

1982 • 239 citations

The Synaptosome

1969 • 197 citations

Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation.

1975 • 168 citations

Reduction of adenylate cyclase activity in lysates of human platelets by the alpha-adrenergic component of epinephrine.

1976 • 165 citations

Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.

1983 • 164 citations

Two affinity states of Ri adenosine receptors in brain membranes. Analysis of guanine nucleotide and temperature effects on radioligand binding.

1984 • 164 citations

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.

1979 • 155 citations

Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine.

1980 • 155 citations

Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.

1980 • 141 citations

8-Phenyltheophylline: A potent P1-purinoceptor antagonist

1981 • 138 citations

Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts

1981 • 137 citations

Adenosine receptors in fat cells. Identification by (-)-N6-[3H]phenylisopropyladenosine binding.

1981 • 118 citations

The enzymatic preparation of [γ-^ P] nucleotide triphosphate, cyclic [^ P] AMP, and cyclic GMP

1979 • 106 citations

Ra Adenosine receptors in human platelets

1984 • 102 citations

Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.

1975 • 98 citations

5′‐N‐ETHYLCARBOXAMIDOADENOSINE: A POTENT INHIBITOR OF HUMAN PLATELET AGGREGATION

1981 • 69 citations

Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors.

1977 • 59 citations

Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: Evaluation of structure-activity relationships

1982 • 47 citations

Mesoionic xanthine analogs: antagonists of adenosine receptors

1984 • 28 citations

Activation and inhibition of lipolysis in isolated fat cells by various inhibitors of cyclic AMP phosphodiesterase

1972 • 25 citations

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