The Physiological Role of Adenosine In The Central Nervous System

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

1929 • 1,470 citations

The Pharmacological Basis of Therapeutics

1976 • 1,403 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

The role of adenosine and its nucleotides in central synaptic transmission

1981 • 767 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

The Relationship between Caffeine Contracture of Intact Muscle and the Effect of Caffeine on Reticulum

1968 • 683 citations

Adenosine receptors: targets for future drugs

1982 • 681 citations

Research advances in alcohol and drug problems

1975 • 578 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines

1981 • 535 citations

Modulation of neurotransmission by purine nucleotides and nucleosides

1980 • 526 citations

Release of Adenosine from Ischemic Brain

1974 • 514 citations

Injections of drugs into the lateral ventricle of the cat

1954 • 514 citations

Physiological roles for adenosine and adenosine 5′-triphosphate in the nervous system

1981 • 484 citations

Neurosecretion and Brain Peptides

1982 • 458 citations

Regulatory Function of Adenosine

1983 • 454 citations

Aminopyridines and synaptic transmission

1980 • 404 citations

Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.

1982 • 393 citations

Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre

1982 • 390 citations

The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat

1972 • 366 citations

ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS

1980 • 357 citations

Paired‐pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus

1980 • 340 citations

Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex

1979 • 338 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Physiology and pharmacology of adenosine derivatives

1984 • 311 citations

An analysis of facilitation of transmitter release at the neuromuscular junction of the frog

1967 • 302 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus

1983 • 257 citations

The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine

1976 • 252 citations

Adenosine Receptors: Autoradiographic Evidence for Their Location on Axon Terminals of Excitatory Neurons

1983 • 244 citations

Adenosine analogs and sleep in rats.

1984 • 239 citations

Xanthine derivatives as adenosine receptor antagonists

1982 • 239 citations

Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro

1980 • 229 citations

Micro‐iontophoretic studies on neurones in the cuneate nucleus

1967 • 227 citations

Cerebral microcirculation and metabolism

1982 • 227 citations

Endogenously Released Adenosine Regulates Excitability in the In Vitro Hippocampus

1980 • 225 citations

On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings.

1984 • 214 citations

Brain adenosine production in the rat during 60 seconds of ischemia.

1979 • 213 citations

Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum

1979 • 210 citations

Release of norepinephrine in the central nervous system by theophylline and caffeine

1970 • 210 citations

Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.

1976 • 209 citations

The biogenesis of adrenal chromaffin granules

1977 • 203 citations

Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure.

1980 • 196 citations

Purinergic inhibition of diazepam binding to rat brain ()

1979 • 195 citations

EFFECTS OF NOREPINEPHRINE ON THE MORPHOLOGY AND SOME ENZYME ACTIVITIES OF PRIMARY MONOLAYER CULTURES FROM RAT BRAIN

1978 • 181 citations

Cytochemical localization of 5′-nucleotidase in glial plasma membranes

1978 • 179 citations

Alkylxanthines elevate hippocampal excitability

1981 • 178 citations

Enhancement of synaptic transmission by 4‐aminopyridine in hippocampal slices of the rat.

1982 • 177 citations

Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides.

1977 • 175 citations

The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline

1976 • 175 citations

Adenosine actions and adenosine receptors after 1 week treatment with caffeine

1982 • 174 citations

Protective effect of adenosine and nicotinamide against audiogenic seizure

1974 • 170 citations

Intracellular analysis of a postsynaptic action of adenosine in the rat hippocampus

1982 • 167 citations

Analysis and quantitative evaluation of the depressive effect of adenosine on evoked potentials in hippocampal slices

1979 • 166 citations

Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission

1984 • 166 citations

ADENOSINE INHIBITION OF γ‐AMINOBUTYRIC ACID RELEASE FROM SLICES OF RAT CEREBRAL CORTEX

1980 • 163 citations

Levels of adenosine and adenine nucleotides in slices of rat hippocampus

1984 • 160 citations

Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists

1975 • 158 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Preliminary data on the possible hypnogenic role of adenosine¹

1973 • 157 citations

Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine.

1980 • 155 citations

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex

1978 • 154 citations

A potent depressant action of adenine derivatives on cerebral cortical neurones

1975 • 152 citations

CYCLIC AMP MEDIATION OF NOREPINEPHRINE INHIBITION IN RAT CEREBELLAR CORTEX: A UNIQUE CLASS OF SYNAPTIC RESPONSES

1971 • 151 citations

Adenosine depression of hippocampal neurons in vitro: An intracellular study of dose-dependent actions on synaptic and membrane potentials

1981 • 151 citations

Adenosine-dependent formation of cyclic AMP in brain slices

1976 • 149 citations

THE EFFECTS OF INTRAVENOUSLY ADMINISTERED AMINOPHYLLINE ON CEREBRAL CIRCULATION AND METABOLISM IN MAN 1

1950 • 149 citations

Chronic caffeine consumption increases the number of brain adenosine receptors

1983 • 147 citations

Depression of Corticospinal Cells by Various Purines and Pyrimidines

1974 • 146 citations

Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens

1977 • 145 citations

Regulation of Adenosine 3′:5′-Monophosphate Content in Human Astrocytoma Cells by Adenosine and the Adenine Nucleotides

1974 • 144 citations

Inhibitory action of adenosine on synaptic transmission in the hippocampus of the guinea pig in vitro

1980 • 143 citations

Adenosine Receptor Agonists Inhibit K⁺‐Evoked Ca²⁺ Uptake by Rat Brain Cortical Synaptosomes

1982 • 142 citations

An A1-adenosine receptor, characterized by [3H]cyclohexyladenosine binding, mediates the depression of evoked potentials in a rat hippocampal slice preparation

1982 • 140 citations

Adenosine Receptors Mediating Cyclic AMP Productioin the Rat Hippocampus

1982 • 137 citations

Stimulation-dependent release of 3H-adenosine derivatives from central axon terminals to target neurones

1976 • 136 citations

Effects of catecholamines and adenosine derivatives given into the brain of fowls

1972 • 136 citations

The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.

1969 • 131 citations

Adenosine receptors mediating inhibitory electrophysiological responses in rat hippocampus are different from receptors mediating cyclic AMP accumulation

1984 • 129 citations

Central effects of adenosine analogs on locomotor activity in mice and antagonism of caffeine

1983 • 128 citations

Effects of chronic caffeine on brain adenosine receptors: Regional and ontogenetic studies

1984 • 128 citations

Interactions in the behavioral effects of methylxanthines and adenosine derivatives.

1983 • 128 citations

Anticonvulsant effects of adenosine analogues on amygdaloid-kindled seizures in rats

1984 • 125 citations

Purinergic Neurotransmission and Neuromodulation

1983 • 124 citations

Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium

1979 • 124 citations

DEPRESSION OF EVOKED POTENTIALS IN BRAIN SLICES BY ADENOSINE COMPOUNDS

1978 • 124 citations

Purinergic depression of neurons in different areas of the rat brain

1977 • 123 citations

Caffeine antagonizes several central effects of diazepam

1981 • 123 citations

Possible role of adenosine in the CNS effects of ethanol

1983 • 122 citations

Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism.

1979 • 122 citations

Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure

1980 • 122 citations

Drugs, Alcohol and Driving

1979 • 121 citations

In vivo bahavioral assessment of central nervous system purinergic receptors

1981 • 120 citations

Cyclic adenosine monophosphate antagonism of morphine analgesia.

1973 • 119 citations

Autoradiographic visualization of rat brain adenosine receptors using N6-cyclohexyl [3H]adenosine

1981 • 118 citations

Heterogeneity of adenosine A1 receptor binding in brain tissue.

1982 • 115 citations

The Rapid Uptake and Release of [³H]Adenosine by Rat Cerebral Cortical Synaptosomes

1981 • 114 citations

Adenosine inhibits calcium spikes in hippocampal pyramidal neurons in vitro

1983 • 114 citations

[3H]5?-N-ethylcarboxamide adenosine binds to both Ra and Ri adenosine receptors in rat striatum

1984 • 110 citations

The Metabolism of Purine and Pyrimidine Nucleotides in Rat Cortex During Insulin‐Induced Hypoglycemia and Recovery

1981 • 110 citations

On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat

1983 • 106 citations

The dextro and levorotatory isomers of N-phenylisopropyladenosine: Stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices

1979 • 106 citations

Modulation of Striatal Dopaminergic Function by Local Injection of 5′- N -Ethylcarboxamide Adenosine

1982 • 104 citations

GDP binding to rat brown fat mitochondria: effects of thyroxine at different ambient temperatures

1981 • 101 citations

N6 (L-Phenylisopropyl)adenosine (L-PIA) increases slow-wave sleep (S2) and decreases wakefulness in rats

1982 • 99 citations

Complete, reversible, drug-specific tolerance to stimulation of locomotor activity by caffeine

1983 • 98 citations

Concomitant changes in cyclic AMP level and postsynaptic potentials of olfactory cortex slices induced by adenosine derivatives

1976 • 97 citations

Uptake by central nervous tissues as a mechanism for the regulation of extracellular adenosine concentrations

1984 • 97 citations

Release of adenosine 5′-triphosphate from synaptosomes from different regions of rat brain

1980 • 97 citations

Effects of Caffeine and Theophylline on Activity of Rats in Relation to Brain Xanthine Concentrations

1972 • 97 citations

Diazepam potentiation of purinergie depression of central neurons

1979 • 96 citations

The ionic basis of adenosine receptor actions on post‐ganglionic neurones in the rat.

1983 • 94 citations

EFFECTS OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON SCHEDULED CONTROLLED RESPONDING IN RATS

1982 • 93 citations

Adenosine cyclic 3',5'-monophosphate in fetal rat brain cell cultures. I. Effect of catecholamines.

1972 • 92 citations

Characterization of adenosine receptors in brain using N6 cyclohexyl [3H]adenosine

1982 • 91 citations

Output of [14C]adenine nucleotides and their derivatives from cerebral tissues. Tetrodotoxine-resistant and calcium ion-requiring components

1973 • 91 citations

Effects of purine compounds on cholinergic nerves. Specificity of adenosine and related compounds on acetylcholine release in electrically stimulated guinea pig ileum

1978 • 90 citations

Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain

1982 • 88 citations

Differential location of adenosine A1 and A2 receptors in striatum

1983 • 86 citations

Behavioral sensitivity to purinergic drugs parallels ethanol sensitivity in selectively bred mice

1984 • 86 citations

Regulation of the strength of adenosine modulation in the hippocampus by a differential distribution of the density of A1 receptors

1983 • 84 citations

Release of Adenosine‐like Material from Isolated Perfused Dog Adipose Tissue Following Sympathetic Nerve Stimulation and its Inhibition by Adrenergic α‐Receptor Blockade

1976 • 81 citations

Inhibition of brain adenylate cyclase by A1 adenosine receptors: Pharmacological characteristics and locations

1983 • 81 citations

Up-regulation of rat cortical adenosine receptors following chronic administration of theophylline

1982 • 80 citations

The locus coeruleus: actions of psychoactive drugs

1983 • 80 citations

Excitation of single sensory neurones in the rat caudal trigeminal nucleus by iontophoretically applied adenosine 5′-triphosphate

1983 • 80 citations

Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other agonists.

1979 • 78 citations

Adenosine-sensitive adenylate cyclase in rat brain homogenates: kinetic characteristics, specificity, topographical, subcellular and cellular distribution.

1979 • 78 citations

Adenosine Measurement by a Rapid HPLC‐Fluorometric Method: Induced Changes of Adenosine Content in Regions of Rat Brain

1982 • 78 citations

EFFECTS OF DIAZEPAM ON ADENOSINE AND ACETYLCHOLINE RELEASE FROM RAT CEREBRAL CORTEX: FURTHER EVIDENCE FOR A PURINERGIC MECHANISM IN ACTION OF DIAZEPAM

1980 • 76 citations

Receptor-linked cyclic amp systems in rat neostriatum: Differential localization revealed by kainic acid injection

1978 • 76 citations

Correlation of 5′-nucleotidase activity and selective transneuronal transfer of adenosine in the hippocampus

1979 • 75 citations

Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosine

1980 • 74 citations

Release of ³H‐nucleosides from ³H‐adenine labelled hypothalamic synaptosomes

1979 • 73 citations

Adenosine receptors and the actions of methylxanthines

1981 • 73 citations

THE EFFECT OF THEOPHYLLINE WITH ETHYLENEDIAMINE (AMINOPHYLLINE) AND CAFFEINE ON CEREBRAL HEMODYNAMICS AND CEREBROSPINAL FLUID PRESSURE IN PATIENTS WITH HYPERTENSIVE HEADACHES

1952 • 72 citations

Heterogeneous distribution of adenosine transport sites labelled by [3H]nitrobenzylthioinosine in rat brain: An autoradiographic and membrane binding study

1984 • 71 citations

Adenosine — a selective neuromodulator in the mammalian CNS?

1984 • 68 citations

Neuronal location of N6-cyclohexyl[3H]adenosine binding sites in rat and guinea-pig brain

1982 • 67 citations

Regulation of breathing in the rat: Indications for a role of central adenosine mechanisms

1982 • 66 citations

The Hippocampal Slice: A System for Studying the Pharmacology of Seizures and for Screening Anticonvulsant Drugs

1977 • 65 citations

Modulation of low calcium induced field bursts in the hippocampus by monoamines and cholinomimetics

1984 • 64 citations

Hypnotic effects of deoxycorformycin in rats

1983 • 64 citations

Adenosine and cyclic AMP in cerebral cortex of rats in hypoxia, status epilepticus and hypercapnia

1978 • 63 citations

Adenosine A1 Receptors Are Associated with Cerebellar Granule Cells

1983 • 63 citations

Effect of adenosine, adenosine triphosphate, adenosine deaminase, dipyridamole and aminophylline on acetylcholine release from electrically-stimulated brain slices

1983 • 62 citations

Behavioral characterization of two long-lasting adenosine analogs: Sedative properties and interaction with diazepam

1981 • 61 citations

Inhibition of adenosine uptake into rat brain synaptosomes by the benzodiazepines

1981 • 60 citations

Morphine increases depolarization induced purine release from rat cortical slices

1978 • 59 citations

Cerebral and systemic circulatory effects of arterial hypotension induced by adenosine

1983 • 58 citations

Depolarization‐Evoked Accumulation of Cyclic AMP in Brain Slices: The Requisite Intermediate Adenosine is Not Derived from Hydrolysis of Released ATP

1980 • 58 citations

Functional identification of adenylate cyclase-coupled adenosine receptors in rat brain microvessels

1982 • 57 citations

Inhibitory action of adenosine and adenosine analogs on neutrotransmission in the olfactory cortex slice of guinea pig — Structure-activity relationships

1980 • 57 citations

Cyclic nucleotides in the nervous system

1978 • 57 citations

HISTAMINE H₁‐AGONIST POTENTIATION OF ADENOSINE‐STIMULATED CYCLIC AMP ACCUMULATION IN SLICES OF GUINEA‐PIG CEREBRAL CORTEX: COMPARISON OF RESPONSE AND BINDING PARAMETERS

1982 • 57 citations

Regional release of [³H] adenosine derivatives from rat brain in vivo: effect of excitatory amino acids, opiate agonists, and benzodiazepines

1980 • 56 citations

Characteristics of the release of adenosine from slices of rat cerebral cortex.

1980 • 55 citations

Neuronal, glial and meningeal localizations of neurotransmitter-sensitive adenylate cyclases in cerebral cortex of mice

1981 • 53 citations

Adenosine receptors in rat testes: Labeling with 3Hcyclohexyladenosine

1981 • 52 citations

Endogenous adenosine inhibits excitatory transmission in the rat olfactory cortex slice

1983 • 52 citations

Methylxanthine activation of noradrenergic unit activity and reversal by clonidine

1982 • 52 citations

Dissociation of the locomotor and hypotensive effects of adenosine analogues in the rat

1984 • 51 citations

Electrophysiological responses to adenosine analogs in rat hippocampus and cerebellum: Evidence for mediation by adenosine receptors of the A1 subtype

1984 • 51 citations

The role of adenosine in CBF increases during hypoxia in young vs aged rats.

1984 • 50 citations

Swelling and ion uptake in cat cerebrocortical slices:

1983 • 49 citations

Inhibitory action of adenosine, 5-HT (serotonin) and GABA (γ-aminobutyric acid) on the postsynaptic potential (PSP) of slices from olfactory cortex and superior colliculus in correlation to the level of cyclic AMP

1979 • 49 citations

Adenosine and Cyclic AMP in Rat Cerebral Cortical Slices: Effects of Adenosine Uptake Inhibitors and Adenosine Deaminase Inhibitors

1981 • 49 citations

Adenosine receptor interactions and anxiolytics

1983 • 48 citations

Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat

1979 • 47 citations

Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons

1979 • 47 citations

Adenosine uptake inhibitors potentiate the sedative effects of adenosine

1983 • 46 citations

Location of adenosine release and adenosine A2 receptors to rat striatal neurons

1983 • 44 citations

Release of norepinephrine and dopamine from brain vesicular preparations: Effects of adenosine analogues

1982 • 43 citations

Up-regulation of brain [3H]diazepam binding sites in chronic caffeine-treated rats

1984 • 43 citations

Release of radiolabelled adenosine derivatives from superfused synaptosome beds

1981 • 42 citations

Effect of adenosine versus adenine nucleotides on evoked potentials in a rat hippocampal slice preparation

1981 • 40 citations

Evidence for an A2-like adenosine receptor on cerebral cortical neurons

1982 • 40 citations

Pyrazolo [3,4-d] pyrimidines, a new class of adenosine antagonists

1983 • 40 citations

Effects of inhibitors and adenosine on (HCO3−/CO2)-stimulated swelling and Cl− uptake in brain slices and cultured astrocytes

1978 • 40 citations

Purine receptors involved in the depression of neuronal firing in cerebral cortex

1982 • 37 citations

Inhibitory Action of Adenosine and Adenine Nucleotides on the Postsynapptic Potential of Olfactory Cortex Slices of the Guinea Pig

1975 • 37 citations

Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines

1979 • 37 citations

THE EFFECTS OF MORPHINE AND METHIONINE‐ENKEPHALIN ON THE RELEASE OF PURINES FROM CEREBRAL CORTEX SLICES OF RATS AND MICE

1981 • 36 citations

Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins, benzodiazepines and other centrally active compounds

1983 • 36 citations

Effect of the Organic Calcium Antagonist D-600 on Cerebrocortical Vascular and Redox Responses Evoked by Adenosine, Anoxia, and Epilepsy

1983 • 35 citations

Inhibition of acetylcholine turnover rate in rat hippocampus and cortex by intraventricular injection of adenosine analogs.

1982 • 35 citations

Inhibition of noradrenaline release from hippocampal slices by a stable adenosine analogue.

1983 • 35 citations

Adenosine's role in the central actions of the benzodiazepines

1984 • 35 citations

Release of [14C]adenosine derivatives from superfused synaptosome preparations. Effects of depolarizing agents and metabolic inhibitors

1980 • 34 citations

Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative

1981 • 34 citations

A Combined In Vivo/In Vitro Study of the Presynaptic Release of Adenosine Derivatives in the Hippocampus

1982 • 33 citations

Cerebral and renal vascular smooth muscle responses to adenosine

1969 • 31 citations

Uptake and release of adenosine by cultured astrocytoma cells

1979 • 30 citations

Some Biochemical Properties of the Rapid Adenosine Uptake System in Rat Brain Synaptosomes

1981 • 30 citations

The effects of AMP on the potential of rat cerebral cortical neurones

1976 • 30 citations

Adenosine mediates sedative action of various centrally active drugs

1982 • 30 citations

Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors.

1981 • 29 citations

4‐AMINOPYRIDINE BLOCKADE OF NEURONAL DEPRESSANT RESPONSES TO ADENOSINE TRIPHOSPHATE

1980 • 29 citations

The effect of diazepam on adenosine uptake and adenosine-stimuiated adenylate cyclase in guinea-pig brain

1982 • 29 citations

Presynaptic depression of synaptic response of Renshaw cells by adenosine 5′-monophosphate

1977 • 27 citations

Change of Cyclic AMP Level in Synaptosomes from Cerebral Cortex; Increase by Adenosine Derivatives

1981 • 27 citations

SUBCELLULAR LOCALIZATION OF [¹⁴C]ADENINE DERIVATIVES NEWLY‐FORMED IN CEREBRAL TISSUES AND THE EFFECTS OF ELECTRICAL EXCITATION

1973 • 27 citations

Synaptosomal calcium uptake unaltered by adenosine and 2-chloroadenosine

1985 • 26 citations

Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo.

1983 • 26 citations

Effect of intraventricular adenosine on food intake in rats

1983 • 26 citations

Methylxanthines modulate adenosine release from slices of cerebral cortex

1981 • 24 citations

Naltrexone improves survival rate and cardiovascular function in canine hemorrhagic shock.

1982 • 24 citations

Inhibition of adenosine accumulation by a CNS benzodiazepine antagonist (Ro 15–1788) and a peripheral benzodiazepine receptor ligand (Ro 05–4864)

1983 • 23 citations

The Effect of Some Drugs with Purported Antianoxic Effect on Veratridine‐induced Purine Release from Isolated Rat Hypothalamic Synaptosomes

1983 • 23 citations

Regulation of microcirculation in the brain

1980 • 23 citations

Inhibition by etazolate (SQ 20009) and cartazolate (SQ 65396) of adenosine-stimulated [3H]cAMP formation in [2-3H]adenine-prelabeled vesicles prepared from guinea pig cerebral cortex

1982 • 22 citations

Neuronal Release of Adenosine Derivatives and Modulation of Signal Processing in the CNS

1982 • 20 citations

EVIDENCE THAT MORPHINE AND OPIOID PEPTIDES DO NOT SHARE A COMMON PATHWAY WITH ADENOSINE IN INHIBITING ACETYLCHOLINE RELEASE FROM ISOLATED INTESTINE

1981 • 19 citations

Coenzyme A is a purine nucleotide modulator of acetylcholine output

1978 • 18 citations

Is the benzodiazepine receptor purinergic?

1979 • 16 citations

Potentiation of pharmacological responses to adenosine, in vitro and in vivo

1982 • 16 citations

High Concentrations of Calcium Prevent the Inhibition of Postsynaptic Potentials and the Accumulation of Cyclic AMP Induced by Adenosine in Brain Slices

1976 • 15 citations

Effects of adenosine and related compounds on an inhibitory process in rat cerebral cortex

1980 • 15 citations

Adenosine receptors in the mammalian central nervous system

1983 • 14 citations

Effects of ethanol on acetylcholine and adenosine efflux from the in vivo rat cerebral cortex

1980 • 14 citations

Adenosine and related compounds do not affect nerve terminal excitability in rat CNS

1980 • 13 citations

Single-dose tolerance to the behavioral effects of dibutyryl cyclic AMP in mice

1977 • 13 citations

Uptake of Adenosine by Cultured Cerebral Vascular Smooth Muscle Cells

1983 • 13 citations

Effects of morphine and caffeine on adenosine release from rat cerebral cortex: is caffeine a morphine antagonist

1980 • 13 citations

Neuronal (Na+,K+)-ATPase and the release of purines from mouse and rat cerebral cortex

1980 • 12 citations

Discriminative stimulus properties of -phenylisopropyl adenosine: Blockade by caffeine and generalization to 2-chloroadenosine

1983 • 10 citations

Methylxanthines antagonize adenosine but not morphine inhibition in guinea pig ileum

1981 • 10 citations

Effects of 2-chloroadenosine on electrical potentials in brain synaptic membrane vesicles

1981 • 10 citations

Cerebral Vascular Smooth Muscle and its Control

1979 • 9 citations

Adenosine Causes Dilatation and Constriction of Hypothalamic Blood Vessels

1983 • 9 citations

Neurotoxicity of deoxycoformycin: effect of constant infusion on adenosine deaminase, adenosine, 2'-deoxyadenosine and monoamines in the mouse brain

1983 • 9 citations

A historical and biological overview: brain transmitters, receptors single cells, and a new treatment for opiate addiction.

1982 • 8 citations

Release of adenosine in vivo from cat caudate nucleus

1983 • 7 citations

The effect of a long-acting adenosine analog on blood flow through various organs in the dog

1983 • 5 citations

ANTAGONISM OF THE ACTIONS OF VARIOUS PSYCHOTROPIC AGENTS BY CAFFEINE

1984 • 2 citations