Efficient Retroviral-Mediated Gene Transfer to Human Cord Blood Stem Cells With In Vivo Repopulating Potential

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

1995 • 1,223 citations

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

1996 • 795 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Clonal and systemic analysis of long-term hematopoiesis in the mouse.

1990 • 577 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic– scid/scid mice

1997 • 495 citations

Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients

1993 • 434 citations

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

1984 • 407 citations

An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse

1989 • 406 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Transient nature of early haematopoietic spleen colonies

1982 • 377 citations

Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.

1996 • 360 citations

Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells

1993 • 296 citations

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

1996 • 281 citations

Peripheral blood lymphocytes as target cells of retroviral vector- mediated gene transfer

1994 • 246 citations

Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor

1996 • 234 citations

Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors.

1994 • 228 citations

Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell.

1989 • 209 citations

Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice.

1996 • 186 citations

Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells

1995 • 182 citations

FLT3 Ligand Preserves the Ability of Human CD34+ Progenitors to Sustain Long-Term Hematopoiesis in Immune-Deficient Mice After Ex Vivo Retroviral-Mediated Transduction

1997 • 161 citations

High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations.

1996 • 147 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 141 citations

Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease.

1993 • 122 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 121 citations

Sustained proliferation, multi‐lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood

1997 • 117 citations

High efficiency retroviral mediated gene transduction into single isolated immature and replatable CD34(3+) hematopoietic stem/progenitor cells from human umbilical cord blood.

1993 • 106 citations

Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer

1995 • 103 citations

Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.

1989 • 98 citations

Phenotypic and functional characterization of long-term culture- initiating cells present in peripheral blood progenitor collections of normal donors treated with granulocyte colony-stimulating factor

1996 • 94 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 93 citations

High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments]

1989 • 83 citations

Sustained High-Level Reconstitution of the Hematopoietic System by Preselected Hematopoietic Cells Expressing a Transduced Cell-Surface Antigen

1997 • 80 citations

Impaired Steel Factor Responsiveness Differentially Affects the Detection and Long-Term Maintenance of Fetal Liver Hematopoietic Stem Cells In Vivo

1997 • 79 citations

Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer

1996 • 78 citations

Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures.

1992 • 73 citations

Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines.

1992 • 72 citations

Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene

1995 • 59 citations

A Phase I Study of Autologous Bone Marrow Transplantation with Stem Cell Gene Marking in Multiple Myeloma. The Toronto Hospital, Ontario, Canada

1995 • 33 citations

Factors affecting the transduction of pluripotent hematopoietic stem cells: long-term expression of a human adenosine deaminase gene in mice

1993 • 31 citations

Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy

1997 • 27 citations

Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy

1997 • 5 citations