Rac and Cdc42 Effectors

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1992 • 562 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

The Dbl family of oncogenes

1996 • 497 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

1996 • 387 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 374 citations

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.

1995 • 365 citations

Characterization of a novel protein‐binding module — the WW domain

1995 • 365 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1

1996 • 315 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Signal transduction and actin filament organization

1996 • 309 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b−245

1987 • 292 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 290 citations

Emerging from the Pak: the p21-activated protein kinase family

1997 • 285 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

The Ras GTPase-Activating-Protein-Related Human Protein IQGAP2 Harbors a Potential Actin Binding Domain and Interacts with Calmodulin and Rho Family GTPases

1996 • 256 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1996 • 253 citations

Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin Cytoskeleton

1997 • 252 citations

IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments

1997 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.

1996 • 248 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.

1996 • 237 citations

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

1997 • 234 citations

Identification of a human rasGAP-related protein containing calmodulin-binding motifs.

1994 • 231 citations

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.

1996 • 229 citations

Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation

1996 • 225 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.

1994 • 217 citations

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

1997 • 214 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

1996 • 213 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 210 citations

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase

1997 • 207 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

1991 • 207 citations

p70 S6 kinase: an enigma with variations

1996 • 202 citations

The PRK2 Kinase Is a Potential Effector Target of both Rho and Rac GTPases and Regulates Actin Cytoskeletal Organization

1997 • 195 citations

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

1995 • 190 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

A novel type of myosin implicated in signalling by rho family GTPases.

1995 • 176 citations

Identification of a novel Rac1-interacting protein involved in membrane ruffling.

1996 • 171 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

How ras-related proteins talk to their effectors

1996 • 162 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

1995 • 158 citations

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.

1995 • 157 citations

Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

1995 • 155 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

Does Vav bind to F‐actin through a CH domain?

1995 • 145 citations

Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome

1986 • 143 citations

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.

1996 • 143 citations

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.

1992 • 141 citations

Identification of an Actin Cytoskeletal Complex That Includes IQGAP and the Cdc42 GTPase

1997 • 141 citations

Identification of a Putative Effector for Cdc42Hs with High Sequence Similarity to the RasGAP-related Protein IQGAP1 and a Cdc42Hs Binding Partner with Similarity to IQGAP2

1996 • 139 citations

Calmodulin Modulates the Interaction between IQGAP1 and Cdc42

1997 • 137 citations

Rac Binding to p67

1997 • 135 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

1995 • 125 citations

Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.

1997 • 120 citations

Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.

1996 • 116 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis

1997 • 113 citations

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

1997 • 104 citations

Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 • 96 citations

Fas-induced Apoptosis Is Mediated by Activation of a Ras and Rac Protein-regulated Signaling Pathway

1996 • 96 citations

Prenylation of RhoB Is Required for Its Cell Transforming Function but Not Its Ability to Activate Serum Response Element-dependent Transcription

1997 • 92 citations

Generation of cell polarity in yeast

1996 • 89 citations

The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.

1997 • 88 citations

DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum

1996 • 76 citations

Genghis Khan (Gek) as a putative effector forDrosophilaCdc42 and regulator of actin polymerization

1997 • 71 citations

Disease mechanism: Unravelling Wiskott–Aldrich syndrome

1996 • 59 citations

A Ras GAP is essential for cytokinesis and spatial patterning in Dictyostelium

1997 • 58 citations

Nuclear signalling by Rac GTPase: essential role of phospholipase A2

1997 • 34 citations

Wiskott-Aldrich Syndrome protein, WASP

1999 • 22 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 17 citations