Vascular endothelial growth factor

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Angiogenesis.

1992 • 2,581 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

1994 • 1,269 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1995 • 990 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

1992 • 865 citations

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

1996 • 788 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Prognostic value of vascular endothelial growth factor expression in gastric carcinoma

1996 • 648 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

1993 • 645 citations

Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia—Associated Iris Neovascularization in a Nonhuman Primate

1996 • 638 citations

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

1991 • 626 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Transdifferentiated Retinal Pigment Epithelial Cells are Immunoreactive for Vascular Endothelial Growth Factor in Surgically Excised AgeRelated Macular Degeneration-Related Choroidal Neovascular Membranes.

1998 • 590 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.

1994 • 548 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1989 • 497 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells

1995 • 493 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Assignment of the Vascular Endothelial Growth Factor Gene to Human Chromosome 6p21.3

1996 • 473 citations

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1993 • 467 citations

The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases

1948 • 456 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

1993 • 448 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer

1994 • 404 citations

Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis.

1995 • 397 citations

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy

1994 • 367 citations

Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen

1995 • 357 citations

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

1992 • 355 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1996 • 336 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

Vascular Endothelial Growth Factor Is Sufficient to Produce Iris Neovascularization and Neovascular Glaucoma in a Nonhuman Primate

1996 • 329 citations

Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma

1996 • 316 citations

Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

1994 • 310 citations

The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies

1992 • 309 citations

Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor · Placenta Growth Factor Heterodimer

1995 • 302 citations

Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro.

1994 • 297 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) Expression and Angiogenesis in Cervical Neoplasia

1995 • 285 citations

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells

1995 • 269 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Vascular permeability factor gene expression in normal and neoplastic human ovaries.

1994 • 259 citations

Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121.

1995 • 257 citations

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

1996 • 245 citations

Tumour angiogenesis in prostatic carcinoma with and without bone marrow metastasis: A morphometric study

1992 • 237 citations

Demonstration and characterization of the angiogenic properties of cervical dysplasia.

1994 • 234 citations

Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma.

1996 • 221 citations

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines.

1995 • 207 citations

The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.

1996 • 202 citations

Vascular endothelial growth factor

1993 • 191 citations

Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

1996 • 170 citations

Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells

1996 • 164 citations

Comparative Analysis of Vascular Endothelial Growth Factor Receptors on Retinal and Aortic Vascular Endothelial Cells

1995 • 146 citations

Vascular endothelial growth factor (rhVEGF165) stimulates direct angiogenesis in the rabbit cornea.

1994 • 134 citations

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.

1993 • 131 citations

Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.

1996 • 130 citations

A Novel Promoter for Vascular Endothelial Growth Factor Receptor (flt-1) That Confers Endothelial-specific Gene Expression

1995 • 130 citations

Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells.

1996 • 129 citations

Studies on retinal neovascularization. Friedenwald Lecture.

1980 • 127 citations

Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.

1995 • 118 citations

In Vitro Angiogenic and Proteolytic Properties of Bovine Lymphatic Endothelial Cells

1994 • 111 citations

Growth factor control of extracellular proteolysis

1990 • 104 citations

Targeting the mouse genome: a compendium of knockouts (part II)

1995 • 99 citations

Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma.

1995 • 83 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis

1993 • 74 citations

Targeting the mouse genome: a compendium of knockouts (part III)

1995 • 41 citations

INTENSE FOCAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR MESSENGER-RNA IN HUMAN INTRACRANIAL NEOPLASMS - ASSOCIATION WITH REGIONS OF NECROSIS

1993 • 40 citations

[Immunodetection of vascular endothelial growth factor in the vitreous of eyes with proliferative diabetic retinopathy].

1996 • 10 citations