Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Cooperation between oncogenes

1991 • 792 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.

1989 • 313 citations

Isolation of a src homology 2-containing tyrosine phosphatase.

1992 • 304 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

1991 • 203 citations

Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.

1991 • 198 citations

Genetically Determined Murine Models of Immunodeficiency

1987 • 178 citations

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1992 • 176 citations

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.

1987 • 153 citations

[1] Production of antibodies by inoculation into lymph nodes

1983 • 148 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.

1992 • 124 citations

A thousand and two protein tyrosine phosphatases

1992 • 119 citations

Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56^lck Complex in Human T‐Cell Activation

1989 • 118 citations

Purification and characterization of a protein tyrosine phosphatase containing SH2 domains.

1993 • 107 citations

Characterization of Hematopoietic Intracellular Protein Tyrosine Phosphatases: Description of a Phosphatase Containing an SH2 Domain and Another Enriched in Proline-, Glutamic Acid-, Serine-, and Threonine-Rich Sequences

1992 • 91 citations

Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.

1992 • 82 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 73 citations

Evidence for differential intracellular signaling via CD4 and CD8 molecules.

1994 • 69 citations

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.

1992 • 66 citations

Phenotypic and Functional Effects of the Motheaten Gene on Murine B and T Lymphocytes

1979 • 63 citations

Expression and function of CD8 in a murine T cell hybridoma.

1987 • 63 citations

Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase.

1993 • 60 citations

Association of Hematopoietic Cell Phosphatase with c-Kit After Stimulation with c-Kit Ligand

1993 • 60 citations

The mouse mutant "motheaten." II. Functional studies of the immune system.

1978 • 56 citations

Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters

1988 • 56 citations

The mouse mutant "motheaten". I. Development of lymphocyte populations.

1978 • 49 citations

Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.

1992 • 45 citations

Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2.

1993 • 38 citations

The Mouse Mutant “Motheaten”

1978 • 35 citations

Activation of mitogen-activated protein kinase/ERK-2 in phytohaemagglutin in blasts by recombinant interleukin-2: contrasting features with CD3 activation.

1993 • 28 citations

Functional expression of human CD8 in fully reconstituted mice after retroviral-mediated gene transfer of hemopoietic stem cells.

1992 • 15 citations

Genetically Determined Murine Models Of Immunodeficiency

1987 • 11 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 10 citations