Genetic mechanisms of early neurogenesis in Drosophila melanogaster

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

Detection in situ of genomic regulatory elements in Drosophila.

1987 • 773 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.

1989 • 688 citations

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

1989 • 679 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

The lin-12 locus specifies cell fates in caenorhabditis elegans

1983 • 598 citations

Genetic Control of Wing Disc Development in Drosophila

1975 • 584 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

The achaete-scute gene complex of D. melanogaster: Conserved Domains in a subset of genes required for neurogenesis and their homology to myc

1987 • 501 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

From grasshopper to Drosophila: a common plan for neuronal development

1984 • 475 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.

1988 • 471 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc.

1991 • 444 citations

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex

1988 • 442 citations

Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

1983 • 436 citations

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

1986 • 427 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins

1990 • 407 citations

opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster

1985 • 404 citations

Early events in insect neurogenesis

1985 • 403 citations

Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

1992 • 397 citations

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.

1991 • 390 citations

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein

1990 • 387 citations

Early neurogenesis in wild-typeDrosophila melanogaster

1984 • 372 citations

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor

1985 • 369 citations

Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila

1987 • 366 citations

The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages

1988 • 351 citations

Expression and Function of the Segmentation Gene fushi tarazu During Drosophila Neurogenesis

1988 • 342 citations

Early events in insect neurogenesis

1985 • 339 citations

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1987 • 317 citations

Nucleotide sequence of cloned cDNA of human c-myc oncogene

1983 • 316 citations

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

1990 • 316 citations

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

1994 • 306 citations

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.

1991 • 297 citations

Genesis of the Drosophila peripheral nervous system

1989 • 289 citations

Molecular genetics of the achaete-scute gene complex of D. melanogaster

1985 • 287 citations

Embryogenesis of an insect nervous system:I. A map of the thoracic and abdominal neuroblasts inLocusta migratoria

1976 • 283 citations

The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

1988 • 281 citations

Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.

1989 • 274 citations

Human N-myc is closely related in organization and nucleotide sequence to c-myc

1986 • 273 citations

The expression of three members of the achaete-scute gene complex correlates with neuroblast segregation in Drosophila

1987 • 272 citations

Cell interactions and gene interactions in peripheral neurogenesis.

1993 • 271 citations

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

1988 • 271 citations

Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.

1988 • 251 citations

Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogaster

1978 • 251 citations

Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages

1989 • 248 citations

GENETIC ANALYSIS OF THE ACHAETE-SCUTE SYSTEM OF DROSOPHILA MELANOGASTER

1979 • 247 citations

Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development.

1989 • 246 citations

The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.

1989 • 245 citations

From DNA to form: the achaete-scute complex.

1988 • 241 citations

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

1937 • 235 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Proliferation pattern and early differentiation of the optic lobes in Drosophila melanogaster

1990 • 220 citations

Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.

1992 • 220 citations

Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

1987 • 217 citations

Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.

1983 • 213 citations

Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo

1992 • 211 citations

Structure and distribution of the Notch protein in developing Drosophila.

1989 • 208 citations

Mutant Alleles at the Locus elav in Drosophila melanogaster lead to Nervous System Defects. A Developmental-Genetic Analysis

1985 • 203 citations

The Notch locus of Drosophila melanogaster

1983 • 203 citations

Fate-mapping in wild-typeDrosophila melanogaster

1985 • 201 citations

Segmental organisation of the head in the embryo of Drosophila melanogaster

1986 • 198 citations

A deduced gene product from the Drosophila neurogenic locus, Enhancer of split, shows homology to mammalian G-protein β subunit

1988 • 197 citations

Development and Neurobiology of Drosophila

1980 • 190 citations

CHARACTER CHANGES CAUSED BY MUTATION OF AN ENTIRE REGION OF A CHROMOSOME IN DROSOPHILA

1919 • 183 citations

Neural enhancer-like elements as specific cell markers in Drosophila

1989 • 181 citations

The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.

1988 • 179 citations

Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development.

1989 • 178 citations

Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila

1978 • 176 citations

Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster

1990 • 174 citations

Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia.

1990 • 174 citations

DEVELOPMENTAL ANALYSIS OF THE ACHAETE-SCUTE SYSTEM OF DROSOPHILA MELANOGASTER

1978 • 173 citations

Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.

1992 • 173 citations

Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development.

1988 • 164 citations

The pattern of proliferation of the neuroblasts in the wild-type embryo of Drosophila melanogaster

1987 • 160 citations

Functional interactions of neurogenic genes of Drosophila melanogaster.

1988 • 159 citations

Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta

1990 • 159 citations

Cellular interactions during early neurogenesis of Drosophila melanogaster

1988 • 157 citations

The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein.

1987 • 157 citations

Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins

1990 • 154 citations

An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

1990 • 154 citations

Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.

1994 • 154 citations

The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.

1990 • 153 citations

Two or three bristles.

1955 • 152 citations

The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.

1989 • 150 citations

The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila

1988 • 148 citations

The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila.

1988 • 147 citations

Altered Epidermal Growth Factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions

1993 • 147 citations

The Expression of Neurogenic Loci in Imaginal Epidermal Cells of Drosophila Melanogaster

1984 • 146 citations

The link between dosage compensation and sex differentiation in Drosophila melanogaster

1981 • 145 citations

Independent subpatterns of sense organs require independent genes of the achaete-scute complex in Drosophila larvae

1987 • 144 citations

Genes required for specifying cell fates in Drosophila embryonic sensory nervous system

1990 • 139 citations

Excess function Hairy-wing mutations caused by gypsy and copia insertions within structural genes of the achaete-scute locus of Drosophila

1986 • 139 citations

The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers.

1990 • 138 citations

Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila

1991 • 136 citations

Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.

1982 • 134 citations

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.

1992 • 133 citations

Genetic Interactions in Early Neurogenesis of Drosophila melanogaster

1985 • 133 citations

PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle.

1989 • 131 citations

Gene regulation in two dimensions: the proneural achaete and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region.

1992 • 130 citations

THE GENETIC CONTROL OF CELL LINEAGE DURING NEMATODE DEVELOPMENT

1984 • 130 citations

Fate-mapping in wild-typeDrosophila melanogaster

1985 • 129 citations

Lineage analysis of transplanted individual cells in embryos of Drosophila melanogaster

1987 • 129 citations

The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos

1987 • 129 citations

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.

1991 • 128 citations

asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene.

1993 • 126 citations

Cell determination and regulation during development of neuroblasts and neurones in grasshopper embryo

1984 • 125 citations

Postembryonic brain development in the monarch butterfly,Danaus plexippus plexippus, L.

1969 • 124 citations

Analysis of a Gene in Drosophila

1965 • 123 citations

Mutations of early neurogenesis inDrosophila

1981 • 121 citations

Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster

1987 • 119 citations

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.

1992 • 117 citations

EGF homologous sequences encoded in the genome of Drosophila melanogaster, and their relation to neurogenic genes.

1987 • 116 citations

The extramacrochaetae gene provides information for sensory organ patterning.

1992 • 115 citations

Molecular analysis of the locus elav in Drosophila melanogaster: a gene whose embryonic expression is neural specific.

1987 • 115 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations

Single amino acid substitutions in EGF-like elements of notch and delta modify drosophila development and affect cell adhesion in vitro

1992 • 113 citations

A region of the Drosophila genome necessary for CNS development

1979 • 111 citations

Genes in subdivision IB of the Drosophila melanogaster X-chromosome and their influence on neural development

1987 • 111 citations

Deletion analysis of the achaete-scute locus of Drosophila melanogaster.

1987 • 111 citations

Cell autonomy of expression of neurogenic genes of Drosophila melanogaster.

1987 • 107 citations

Identification and Characterization of a Neuron-Specific Nuclear Antigen in Drosophila

1988 • 106 citations

The effects of zygotic lethal mutations on female germ-line functions in Drosophila

1984 • 105 citations

TEMPERATURE-SENSITIVE MUTATIONS OF THE NOTCH LOCUS IN DROSOPHILA MELANOGASTER

1975 • 104 citations

The Individual Gene in Relation to the Chromomere and the Chromosome

1935 • 104 citations

The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila.

1993 • 103 citations

Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene

1987 • 101 citations

Local function of the notch gene for embryonic ectodermal pathway choice in drosophila

1986 • 100 citations

The enhancer of split locus and neurogenesis in Drosophila melanogaster

1987 • 100 citations

ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system

1992 • 98 citations

Lineage analysis of transplanted individual cells in embryos of Drosophila melanogaster

1986 • 94 citations

The sense organs in theDrosophila larva and their relation to the embryonic pattern of sensory neurons

1986 • 92 citations

The origination of chromatin deficiencies as minute deletions subject to insertion elsewhere

1935 • 92 citations

A unitary basis for different Hairy-wing mutations of Drosophila melanogaster.

1988 • 90 citations

The determination of sense organs in Drosophila: effect of the neurogenic mutations in the embryo

1991 • 88 citations

ALLELIC NEGATIVE COMPLEMENTATION AT THE ABRUPTEX LOCUS OF DROSOPHILA MELANOGASTER

1975 • 88 citations

The peripheral nervous system of mutants of early neurogenesis inDrosophila melanogaster

1986 • 88 citations

Two groups of interrelated genes regulate early neurogenesis in Drosophila melanogaster

1988 • 87 citations

A SEX-SPECIFIC, TEMPERATURE-SENSITIVE MATERNAL EFFECT OF THE DAUGHTERLESS MUTATION OF DROSOPHILA MELANOGASTER

1976 • 83 citations

Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes

1994 • 82 citations

Second-site modifiers of the split mutation of Notch define genes involved in neurogenesis in Drosophila melanogaster

1990 • 80 citations

A single cell approach to problems of cell lineage and commitment during embryogenesis of Drosophila melanogaster

1987 • 79 citations

NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER

1975 • 79 citations

Lineage analysis of transplanted individual cells in embryos of Drosophila melanogaster

1986 • 74 citations

daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo

1994 • 73 citations

The Notch locus of Drosophila is required in epidermal cells for epidermal development

1990 • 73 citations

Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila.

1991 • 72 citations

The pattern of transcription of the neurogenic gene Delta of Drosophila melanogaster

1990 • 72 citations

The determination of sense organs in Drosophila: interaction of scute with daughterless

1988 • 71 citations

MATERNAL AND ZYGOTIC SEX-SPECIFIC GENE INTERACTIONS IN DROSOPHILA MELANOGASTER

1980 • 67 citations

Maternal effects of zygotic mutants affecting early neurogenesis inDrosophila

1982 • 66 citations

Genetic Analysis of Delta, a Neurogenic Gene of Drosophila melanogaster

1987 • 66 citations

Defective neural development inDrosophila melanogaster embryos deficient for the tip of the X chromosome

1980 • 65 citations

Genetic analysis ofHairy-wing mutations

1986 • 61 citations

Genetics of early neurogenesis in Drosophila melanogaster

1985 • 57 citations

GENETIC BASIS FOR TWO TYPES OF RECESSIVE LETHALITY AT THE NOTCH LOCUS OF DROSOPHILA

1971 • 54 citations

A study of shaggy reveals spatial domains of expression of achaete–scute alleles on the thorax of Drosophila

1989 • 53 citations

Mutant Drosophila embryos in which all cells adopt a neural fate

1989 • 52 citations

Cell commitment and cell interactions in the ectoderm of Drosophila melanogaster.

1991 • 51 citations

Genetic analysis of enhancer of split, a locus involved in neurogenesis in Drosophila melanogaster.

1988 • 50 citations

Lineage analysis of transplanted individual cells in embryos of Drosophila melanogaster

1986 • 50 citations

A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster.

1989 • 49 citations

Molecular analysis of the neurogenic locus mastermind of Drosophila melanogaster.

1988 • 46 citations

Genomic regions regulating early embryonic expression of the Drosophila neurogenic gene Delta

1994 • 45 citations

DNA map of mutations at the scute locus of Drosophila melanogaster

1982 • 44 citations

Complex spatio-temporal accumulation of alternative transcripts from the neurogenic geneDeltaduringDrosophilaembryogenesis

1989 • 44 citations

Primary culture of single ectodermal precursors of Drosophila reveals a dorsoventral prepattern of intrinsic neurogenic and epidermogenic capabilities at the early gastrula stage

1992 • 41 citations

Topological specificity of phenotype expression of neurogenic mutations inDrosophila

1983 • 40 citations

INTRAGENIC DELETIONS AND SALIVARY BAND RELATIONSHIPS IN DROSOPHILA

1975 • 40 citations

GENETIC AND DEVELOPMENTAL ANALYSIS OF THE LOCUS vnd IN DROSOPHILA MELANOGASTER

1983 • 39 citations

Cytogenetic definition and morphogenetic analysis of Delta, a gene affecting neurogenesis in Drosophila melanogaster.

1988 • 38 citations

Reversible commitment of neural and epidermal progenitor cells during embryogenesis of Drosophila melanogaster

1988 • 35 citations

Regulatory signals and signal molecules in early neurogenesis of Drosophila melanogaster

1992 • 33 citations

The development of eggs produced by the female‐sterile mutant almondex of Drosophila melanogaster

1973 • 31 citations

THE CYTOGENETIC ANALYSIS OF A FRACTURED GENE IN DROSOPHILA

1974 • 31 citations

Molecular Genetics of Drosophila Neurogenesis

1985 • 29 citations

The recombinational analysis of aberrations and the position of the Notch locus on the polytene chromosome of Drosophila

1981 • 24 citations

Mechanisms Of A Cellular Decision During Embryonic Development Of Drosophila Melanogaster: EPIDERMOGENESIS OR NEUROGENESIS

1990 • 22 citations

Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm

1985 • 21 citations

Molecular organization of master mind, a neurogenic gene of Drosophila melanogaster

1987 • 19 citations

The Notch locus of Drosophila melanogaster: A molecular analysis

1983 • 18 citations

Early events in the development of Drosophila peripheral nervous system.

1990 • 17 citations

Single cell transplantation reveals interspecific cell communication in Drosophila chimeras

1990 • 16 citations

A Genetic Analysis of Early Neurogenesis in Drosophila

1984 • 13 citations

The Distribution of Transcripts of Neurogenic Genes in Neurogenic Mutants ofDrosophila Melanogaster

1991 • 10 citations

Genetic control of neuronal determination in insects

1988 • 8 citations