Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Epidermal Growth Factor

1979 • 2,964 citations

Genetic variations of Drosophila melanogaster

1967 • 2,612 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

Recognition of protein coding regions in DNA sequences

1982 • 927 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 671 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 538 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

Enhanced graphic matrix analysis of nucleic acid and protein sequences.

1981 • 476 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster

1985 • 404 citations

Early events in insect neurogenesis

1985 • 403 citations

Segmental distribution of bithorax complex proteins during Drosophila development

1985 • 397 citations

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression

1984 • 381 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Early neurogenesis in wild-typeDrosophila melanogaster

1984 • 372 citations

The nucleotide sequence of the gene for human protein C.

1985 • 360 citations

Early events in insect neurogenesis

1985 • 339 citations

The Primary Structure of High Molecular Mass Urokinase from Human Urine. The Complete Amino Arid Sequence of the A Chain

1982 • 312 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

1937 • 235 citations

Extracellular nucleases of Pseudomonas BAL 31. III. Use of the double-strand deoxyriboexonuclease activity as the basis of a convenient method for the mapping of fragments of DNA produced by cleavage with restriction enzymes

1978 • 234 citations

Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila

1985 • 219 citations

Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.

1983 • 213 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

The Notch locus of Drosophila melanogaster

1983 • 203 citations

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

1984 • 201 citations

Structure-independent nucleotide sequence analysis.

1979 • 199 citations

The primary structure of high molecular mass urokinase from human urine

1982 • 191 citations

Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor

1985 • 185 citations

Characterization of a cDNA coding for human protein C.

1984 • 183 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila

1978 • 176 citations

Cancer cells. 3: Growth factors and transformation

1985 • 176 citations

A subcloning strategy for DNA sequence analysis

1980 • 161 citations

ALLELIC NEGATIVE COMPLEMENTATION AT THE ABRUPTEX LOCUS OF DROSOPHILA MELANOGASTER

1975 • 88 citations

NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER

1975 • 79 citations

PSEUDOALLELISM AT THE NOTCH LOCUS IN DROSOPHILA

1962 • 60 citations

Genetics of early neurogenesis in Drosophila melanogaster

1985 • 57 citations

The molecular genetics of the Notch locus in Drosophila melanogaster

1985 • 56 citations

GENETIC BASIS FOR TWO TYPES OF RECESSIVE LETHALITY AT THE NOTCH LOCUS OF DROSOPHILA

1971 • 54 citations

Organizing Principles of Neural Development

1984 • 42 citations

Molecular Genetics of Drosophila Neurogenesis

1985 • 29 citations

The recombinational analysis of aberrations and the position of the Notch locus on the polytene chromosome of Drosophila

1981 • 24 citations

A Genetic Analysis of Early Neurogenesis in Drosophila

1984 • 13 citations