Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms

1994 • 3,265 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

1988 • 580 citations

Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat

1984 • 573 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of n-methyl-d-aspartic acid and substance P

1991 • 281 citations

Release of Substance P‐like Immunoreactivity from the Dental Pulp

1977 • 272 citations

Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

1990 • 259 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

Capsaicin-evoked release of substance P from primary sensory neurons

1979 • 227 citations

Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture.

1989 • 225 citations

Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes

1990 • 220 citations

Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells

1984 • 213 citations

Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint

1987 • 192 citations

Responses of primate spinothalamic neurons to graded and to repeated noxious heat stimuli

1979 • 189 citations

Distribution of chemosensitive primary sensory afferents in the central nervous system of the rat

1980 • 189 citations

Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones

1990 • 165 citations

Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

1981 • 161 citations

Unresponsive afferent nerve fibres in the sural nerve of the rat.

1991 • 159 citations

Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to kainate.

1985 • 152 citations

Responses of spinothalamic tract cells in the superficial dorsal horn of the primate lumbar spinal cord.

1987 • 143 citations

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

1989 • 139 citations

The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat

1989 • 134 citations

Neurophysiological effects of capsaicin

1984 • 122 citations

Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input

1985 • 116 citations

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by receptor activation

1988 • 104 citations

Glutamate immunoreactivity in rat dorsal root axons

1989 • 99 citations

Facilitation of the responses of primate spinothalamic cells to cold and to tactile stimuli by noxious heating of the skin

1982 • 98 citations

Effects of capsaicin applied to a peripheral nerve on the responses of primate spinothalamic tract cells

1985 • 91 citations

The consequences of long-term topical capsaicin application in the rat

1991 • 83 citations

Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells

1990 • 62 citations

Peptide immunoreactivity of unmyelinated primary afferent axons in rat lumbar dorsal roots.

1989 • 56 citations

Substance P content of the skin, neurogenic inflammation and numbers of C-fibres following capsaicin application to a cutaneous nerve in the rabbit

1988 • 55 citations

The action of excitatory amino acids on chick spinal cord neurones in culture.

1987 • 55 citations

Studies on the action potentials of sensory nerves in animals desensitized with capsaicine.

1959 • 52 citations

Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli

1983 • 51 citations

Aspartate immunoreactive axons in normal rat L4 dorsal roots

1989 • 44 citations

Long-lasting neuronal activity in rat dorsal horn evoked by impulses in cutaneous C fibres during noxious mechanical stimulation

1988 • 44 citations

Two forms of inhibition of spinothalamic tract neurons produced by stimulation of the periaqueductal gray and the cerebral cortex

1991 • 37 citations

The effects of capsaicin applied to peripheral nerves on responses of a group of lamina I cells in adult rats

1984 • 19 citations