Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

1993 • 841 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

Morphological Basis of Long-Term Habituation and Sensitization in Aplysia

1983 • 420 citations

Regulation of camp-inducible genes by creb

1990 • 416 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization

1985 • 334 citations

Using PCR to Engineer DNA

1989 • 303 citations

Neurite regeneration by Aplysia neurons in dissociated cell culture: modulation by Aplysia hemolymph and the presence of the initial axonal segment

1983 • 281 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

1985 • 243 citations

Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of Aplysia

1989 • 240 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.

1987 • 236 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization

1986 • 174 citations

Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements.

1990 • 162 citations

5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in aplysia sensory neurons

1989 • 149 citations

Use of E. coli lacZ (β-Galactosidase) as a Reporter Gene

2003 • 142 citations

Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

1990 • 132 citations

Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia

1978 • 107 citations

Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons.

1992 • 85 citations

Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene

1991 • 81 citations

Selective activation of Ca(2+)-activated PKCs in Aplysia neurons by 5- HT

1992 • 72 citations

Induction of a cyclic AMP-responsive gene in living cells requires the nuclear factor CREB.

1991 • 56 citations