Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

1994 • 883 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1998 • 568 citations

The Hemopoietic Colony-stimulating Factors

1995 • 565 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

In Vitro Colony Formation by Normal and Leukemic Human Hematopoietic Cells: Characterization of the Colony-Forming Cells 2

1973 • 353 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant mice

1997 • 270 citations

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

1995 • 224 citations

Hemopoietic colonies: in vitro cloning of normal and leukemic cells.

1977 • 202 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

1988 • 177 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Chronic myelogenous leukemia: A review

1996 • 164 citations

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.

1993 • 158 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience.

1994 • 145 citations

Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism

1994 • 140 citations

Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias

1998 • 131 citations

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

1989 • 125 citations

The Src Family Kinase Hck Interacts with Bcr-Abl by a Kinase-independent Mechanism and Phosphorylates the Grb2-binding Site of Bcr

1997 • 124 citations

Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL

1997 • 123 citations

BCR – ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

1998 • 116 citations

The kappaB sites in the human immunodeficiency virus type 1 long terminal repeat enhance virus replication yet are not absolutely required for viral growth

1997 • 107 citations

Signal transduction by wild-type and leukemogenic Abl proteins

1997 • 107 citations

Human factor VIII:C purified using monoclonal antibody to von Willebrand factor.

1988 • 105 citations

Interleukin-3 and its receptor

1995 • 94 citations

In vitro Colony Forming Cells and Colony Stimulating Factor in Chronic Granulocytic Leukaemia

1974 • 92 citations

Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice

1995 • 88 citations

Pulmonary Complications of Leukemia

1990 • 88 citations

Function and Signal Transduction Mediated by the Interleukin 3 Receptor System in Hematopoiesis

1996 • 87 citations

The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation

1995 • 87 citations

Responsiveness of Human Granulocytic Leukemic Cells to Colony-stimulating Factor

1974 • 84 citations

Selective Transformation of Primitive Lymphoid Cells by the BCR/ABL Oncogene Expressed in Long-Term Lymphoid or Myeloid Cultures

1988 • 80 citations

Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.

1989 • 79 citations

Chronic myeloid leukemia

1997 • 78 citations

Retrovirus-Mediated Transfer and Expression of the Interleukin-3 Gene in Mouse Hematopoietic Cells Result in a Myeloproliferative Disorder

1989 • 77 citations

The function of BCR/ABL and related proto-oncogenes

1997 • 71 citations

Drosophila abl and genetic redundancy in signal transduction

1991 • 63 citations

Discordant maturation as the primary biological defect in chronic myelogenous leukemia.

1988 • 63 citations

The Hemopoietic Colony-stimulating Factors: From Biology to Clinical Applications

1995 • 63 citations

Inhibition of Granulocyte-Macrophage Colony-Stimulating Factor Prevents Dissemination and Induces Remission of Juvenile Myelomonocytic Leukemia in Engrafted Immunodeficient Mice

1997 • 56 citations

Diffuse alveolar haemorrhage associated with microangiopathy after allogeneic bone marrow transplantation.

1995 • 56 citations

Bcr‐Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

1998 • 52 citations

Inhibition of proliferation and induction of apoptosis in juvenile myelomonocytic leukemic cells by the granulocyte-macrophage colony- stimulating factor analogue E21R

1996 • 51 citations

Regulation of granulocyte‐macrophage colony‐stimulating factor and interleukin 3 expression

1995 • 51 citations

Fatal pulmonary hemorrhage in patients with acute leukemia and fulminant pneumonia caused by Stenotrophomonas maltophilia

1997 • 49 citations

Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.

1988 • 48 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 47 citations

Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder.

1989 • 47 citations

Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data

1996 • 46 citations

Chronic myelogenous leukemia

1996 • 42 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 35 citations

Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation

1995 • 31 citations

4 Stem cell kinetics

1997 • 30 citations

Signal transduction by the GM-CSF, IL-3 and IL-5 receptors.

1997 • 19 citations

ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.

1993 • 18 citations

Hairy cell leukemia 1992.

1992 • 14 citations

Constitutive expression of GM-CSF mRNA by CML blast cells is correlated with endogenous megakaryocytic colony formation.

1993 • 10 citations

Colony-forming cells in chronic granulocytic leukemia - I. Proliferative responses to growth factors

1985 • 7 citations

Granulocyte-macrophage colony stimulating factor and interleukin-6 enhanced white blood cell synthesis of leukotrienes in chronic myelogenous leukemia.

1997 • 6 citations