Inhibition of proliferation and induction of apoptosis in juvenile myelomonocytic leukemic cells by the granulocyte-macrophage colony- stimulating factor analogue E21R

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1996 • 602 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

1991 • 334 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1996 • 310 citations

Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors

1984 • 171 citations

Rescue from programmed cell death in leukemic and normal myeloid cells

1991 • 165 citations

Mutations of the N-ras gene in juvenile chronic myelogenous leukemia

1994 • 153 citations

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

1992 • 142 citations

Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines.

1991 • 123 citations

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

1994 • 118 citations

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

1994 • 105 citations

A Pilot Study of Isotretinoin in the Treatment of Juvenile Chronic Myelogenous Leukemia

1994 • 98 citations

Central role of tumour necrosis factor, GM‐CSF, and interleukin 1 in the pathogenesis of juvenile chronic myelogenous leukaemia

1992 • 96 citations

Clonality in juvenile chronic myelogenous leukemia

1995 • 90 citations

Allogeneic marrow transplantation for children with juvenile chronic myelogenous leukemia

1988 • 81 citations

Interleukin 1-dependent paracrine granulopoiesis in chronic granulocytic leukemia of the juvenile type.

1988 • 79 citations

The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.

1993 • 77 citations

Granulocyte-macrophage colony-stimulating factor is an endogenous regulator of cell proliferation in juvenile chronic myelogenous leukemia

1989 • 71 citations

The value of intensive combination chemotherapy for juvenile chronic myelogenous leukemia.

1987 • 66 citations

Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.

1995 • 56 citations

The role of monocyte-derived hemopoietic growth factors in the regulation of myeloproliferation in juvenile chronic myelogenous leukemia.

1991 • 54 citations

Lymphoid blast crisis of B-lineage phenotype with monosomy 7 in a patient with juvenile chronic myelogenous leukemia (JCML).

1994 • 39 citations

Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist [see comments]

1994 • 35 citations

Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.

1996 • 33 citations

B-lineage lymphoid blast crisis in juvenile chronic myelogenous leukemia: II. Interleukin-1-mediated autocrine growth regulation of the lymphoblasts.

1995 • 13 citations