Neuroinflammation: Microglia and T Cells Get Ready to Tango

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013 • 4,087 citations

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

2017 • 3,867 citations

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

2012 • 3,415 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

2011 • 2,543 citations

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

2017 • 2,038 citations

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

2014 • 1,933 citations

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

2013 • 1,563 citations

Microglia in neurodegenerative disease

2010 • 1,456 citations

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

2015 • 1,400 citations

A polarizing question: do M1 and M2 microglia exist?

2016 • 1,261 citations

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

2014 • 1,191 citations

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

2002 • 1,167 citations

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

2008 • 1,078 citations

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

2015 • 971 citations

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

2011 • 966 citations

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

2017 • 893 citations

Correction: Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

2015 • 881 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

2010 • 751 citations

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

2016 • 733 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Innate immunity in Alzheimer's disease

2015 • 694 citations

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

2017 • 670 citations

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

2013 • 574 citations

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

2017 • 560 citations

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

2013 • 526 citations

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance

2006 • 525 citations

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

2008 • 436 citations

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

2016 • 434 citations

Aromatic and proteomic analyses corroborate the distinction between Mediterranean landraces and modern varieties of durum wheat

2016 • 434 citations

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

2002 • 429 citations

A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing

1997 • 426 citations

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

2015 • 402 citations

Regulatory T cells promote myelin regeneration in the central nervous system

2017 • 393 citations

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 • 386 citations

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

2006 • 369 citations

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

2014 • 361 citations

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

2011 • 360 citations

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

2016 • 352 citations

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

2015 • 346 citations

Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates

2013 • 339 citations

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

2013 • 339 citations

MHCII Is Required for -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

2013 • 336 citations

Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells

2006 • 333 citations

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

2016 • 331 citations

High-dimensional, single-cell characterization of the brain's immune compartment

2017 • 327 citations

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

2000 • 312 citations

Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

2006 • 311 citations

Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

2003 • 296 citations

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

1993 • 295 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Neuroprotective autoimmunity: Naturally occurring CD4 ⁺ CD25 ⁺ regulatory T cells suppress the ability to withstand injury to the central nervous system

2002 • 261 citations

Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

2008 • 245 citations

T cell responses in the central nervous system

2017 • 228 citations

The role of regulatory T cells in multiple sclerosis

2008 • 224 citations

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

2010 • 223 citations

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

2015 • 219 citations

Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

2003 • 202 citations

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

2011 • 200 citations

Inflammatory changes parallel the early stages of Alzheimer disease

2006 • 193 citations

Nitrated α-Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

2009 • 183 citations

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

2008 • 182 citations

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

2014 • 182 citations

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

2016 • 178 citations

ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity

2017 • 178 citations

Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

2001 • 163 citations

Dual effect of CD4⁺CD25⁺regulatory T cells in neurodegeneration: A dialogue with microglia

2004 • 159 citations

Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease

2015 • 159 citations

TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells

2011 • 156 citations

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

2014 • 150 citations

Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease

2006 • 148 citations

The immunobiology of prion diseases

2013 • 138 citations

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

2010 • 135 citations

Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action

2005 • 135 citations

Understanding the Role of T Cells in CNS Homeostasis

2016 • 134 citations

CD4-Positive T Cell-Mediated Neuroprotection Requires Dual Compartment Antigen Presentation

2004 • 131 citations

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

2014 • 130 citations

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves

2016 • 130 citations

DC-HIL is a negative regulator of T lymphocyte activation

2007 • 121 citations

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study

2014 • 120 citations

By Altering Ocular Immune Privilege, Bone Marrow–derived Cells Pathogenically Contribute to DBA/2J Pigmentary Glaucoma

2003 • 114 citations

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

2011 • 113 citations

CNS myelin induces regulatory functions of DC-SIGN–expressing, antigen-presenting cells via cognate interaction with MOG

2014 • 101 citations

CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

2006 • 92 citations

β-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner

2008 • 90 citations

Recombinant Ig-Like Transcript 3-Fc Modulates T Cell Responses via Induction of Th Anergy and Differentiation of CD8+ T Suppressor Cells

2006 • 89 citations

Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease

2012 • 89 citations

Acute in vivo exposure to interferon-γ enables resident brain dendritic cells to become effective antigen presenting cells

2009 • 86 citations

Regulatory T Cells in Central Nervous System Injury: A Double-Edged Sword

2014 • 79 citations

Complement Receptor 3 Ligation of Dendritic Cells Suppresses Their Stimulatory Capacity

2007 • 72 citations

Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke

2011 • 70 citations

Microglial Activation Milieu Controls Regulatory T Cell Responses

2013 • 68 citations

T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis

2013 • 67 citations

Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model

2012 • 64 citations

Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation

2015 • 64 citations

T Cells Infiltrate the Brain in Murine and Human Transmissible Spongiform Encephalopathies

2003 • 64 citations

The second touch hypothesis: T cell activation, homing and polarization

2014 • 63 citations

The DC‐HIL/syndecan‐4 pathway inhibits human allogeneic T‐cell responses

2009 • 63 citations

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

2015 • 62 citations

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

2015 • 59 citations

The Kinetics of Myelin Antigen Uptake by Myeloid Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis

2013 • 58 citations

Downregulation of Inflammatory MicroRNAs by Ig-like Transcript 3 Is Essential for the Differentiation of Human CD8+ T Suppressor Cells

2012 • 45 citations

CD11c‐positive cells from brain, spleen, lung, and liver exhibit site‐specific immune phenotypes and plastically adapt to new environments

2014 • 39 citations

The second touch hypothesis: T cell activation, homing and polarization

2014 • 36 citations

PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity

2010 • 33 citations

Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease?

2008 • 26 citations

Myelin‐specific <scp>T</scp> cells induce interleukin‐1beta expression in lesion‐reactive microglial‐like cells in zones of axonal degeneration

2015 • 19 citations

CD4 + T cell-mediated immunity against prion proteins

2003 • 10 citations