Inflammatory changes parallel the early stages of Alzheimer disease

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

Inflammation and Alzheimer's disease

2000 • 4,315 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes

2001 • 1,622 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Microglia-specific localisation of a novel calcium binding protein, Iba1

1998 • 1,337 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

2006 • 1,130 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

2004 • 998 citations

Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression

2003 • 955 citations

A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage

1996 • 813 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply

1997 • 704 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Clinico‐pathologic studies in dementia

1988 • 567 citations

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

2005 • 539 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling

2002 • 516 citations

Basic principles of immunological surveillance of the normal central nervous system

2001 • 480 citations

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

2004 • 466 citations

Immune System Response in Alzheimer's Disease

1989 • 457 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

2002 • 429 citations

Chemokines and Their Receptors in the Central Nervous System

2001 • 402 citations

Rofecoxib

2004 • 390 citations

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

2003 • 384 citations

How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

2004 • 362 citations

Brain-immune connection: Immuno-regulatory properties of CNS-resident cells

2000 • 349 citations

The importance of inflammatory mechanisms in alzheimer disease

1998 • 325 citations

A Gene Expression Profile of Alzheimer's Disease

2001 • 304 citations

Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration.

1996 • 300 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

1995 • 265 citations

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

1988 • 248 citations

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

1998 • 246 citations

Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse

2002 • 245 citations

Inflammation, Aβ Deposition, and Neurofibrillary Tangle Formation as Correlates of Alzheimer's Disease Neurodegeneration

1996 • 227 citations

MHC class II‐positive microglia in human brain: Association with alzheimer lesions

1992 • 221 citations

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

2000 • 192 citations

Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease

2000 • 190 citations

Prevalence of Alzheimer’s disease in very elderly people

2001 • 186 citations

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1990 • 174 citations

Neuronal and Glial Coexpression of Argininosuccinate Synthetase and Inducible Nitric Oxide Synthase in Alzheimer Disease

2001 • 144 citations

Apoptosis of inflammatory cells in immune control of the nervous system: Role of glia

2001 • 131 citations

Anti‐Inflammatory Drugs in the Fight against Alzheimer's Diseasea

1996 • 123 citations

Genes, models and Alzheimer's disease

2001 • 108 citations

Microglia Activation in the Brain as Inflammatory Biomarker of Alzheimer’s Disease Neuropathology and Clinical Dementia

2006 • 97 citations

Temporal Sequence of Plaque Formation in the Cerebral Cortex of Non-Demented Individuals

1993 • 94 citations

Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid β-Peptide Presentation to Th1 Cells

2003 • 89 citations

Nonsteroidal Anti-Inflammatory Drug Use and the Risk for Alzheimer???s Disease

2003 • 69 citations

Gene expression profile analysis of lymphocytes from Alzheimer??s patients

2005 • 66 citations

T-Cell Autoimmunity in the Central Nervous System

1993 • 62 citations

Expression of Excitatory Amino Acid Transporter-1 in Brain Macrophages and Microglia of HIV-Infected Patients. A Neuroprotective Role for Activated Microglia?

2003 • 56 citations

Occurrence of HLA‐DR Reactive Microglia in Alzheimer's Disease

1988 • 52 citations

Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease

2002 • 45 citations

Focal Inflammation in the Brain: Role in Alzheimer's Disease

2000 • 41 citations

Genomic regulation after CD40 stimulation in microglia: Relevance to Alzheimer's disease

2005 • 32 citations

HLA class I, II & III genes in confirmed late-onset Alzheimer's disease

2001 • 28 citations

Modulation of MHC Class II Expression in the Absence of Lymphocytic Infiltrates in Alzheimerʼs Retinae

1994 • 25 citations

Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease

1999 • 21 citations

Intracellular pathways involved in TNF-α and superoxide anion release by Aβ(1–42)-stimulated primary human macrophages

2001 • 20 citations

Ibuprofen stereochemistry: double-the-trouble?

1999 • 20 citations

Neurones and microglia in central nervous system immune response to degenerative processes. Part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study.

2001 • 12 citations

Altered response to mirtazapine on gene expression profile of lymphocytes from Alzheimer's patients

2004 • 11 citations