Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

2009 • 1,098 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

2011 • 1,039 citations

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

2010 • 988 citations

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

2011 • 971 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

2012 • 759 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

Stability of the Regulatory T Cell Lineage in Vivo

2010 • 675 citations

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

2012 • 674 citations

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

2012 • 606 citations

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

2009 • 563 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

2012 • 552 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

2008 • 510 citations

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

2008 • 501 citations

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

2009 • 493 citations

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

2011 • 467 citations

Faithful activation of an extra‐bright red fluorescent protein in “knock‐in” Cre‐reporter mice ideally suited for lineage tracing studies

2006 • 462 citations

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

2012 • 461 citations

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

2011 • 407 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

2010 • 405 citations

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

2011 • 404 citations

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

2011 • 396 citations

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

2012 • 294 citations

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

2011 • 281 citations

Protein Kinase C-θ Mediates Negative Feedback on Regulatory T Cell Function

2010 • 278 citations

Response to self antigen imprints regulatory memory in tissues

2011 • 257 citations

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

2011 • 240 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells

2009 • 212 citations

Cutting Edge: Mechanisms of IL-2–Dependent Maintenance of Functional Regulatory T Cells

2010 • 212 citations

T‐cell tolerance and the multi‐functional role of IL‐2R signaling in T‐regulatory cells

2011 • 205 citations

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

2009 • 189 citations

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

2012 • 183 citations

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

2007 • 178 citations

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

2011 • 174 citations

Innate and Adaptive Immune Responses of the Central Nervous System

2006 • 172 citations

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

2010 • 166 citations

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells

2009 • 149 citations

Regulatory T cells: stability revisited

2011 • 102 citations

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

2011 • 70 citations