Microglia induce CD4 T lymphocyte final effector function and death.

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.

1989 • 455 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

1992 • 395 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

T and B memory cells

1994 • 285 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

1990 • 207 citations

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

1990 • 207 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

1986 • 204 citations

Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells

1994 • 203 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

1990 • 194 citations

Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

1986 • 184 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system.

1987 • 178 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

A Repopulation Assay For B and T Lymphocyte Stem Cells Employing Radiation Chimaeras

1981 • 158 citations

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.

1995 • 152 citations

Fatal interactions: fas-induced apoptosis of mature T cells

1994 • 118 citations

Monoclonal Anti-Gamma Interferon Antibodies Enhance Experimental Allergic Encephalomyelitis

1993 • 115 citations

In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ.

1992 • 112 citations

Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.

1991 • 107 citations

Selective activation-induced apoptosis of peripheral T cells imposed by macrophages. A potential mechanism of antigen-specific peripheral lymphocyte deletion.

1996 • 106 citations

Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune transferred experimental autoimmune encephalomyelitis: An investigation using rat radiation bone marrow chimeras

1995 • 100 citations

Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

1993 • 100 citations

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

1993 • 95 citations

Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transduction

1996 • 82 citations

Isolation of encephalitogenic CD4+ T cell clones in the rat

1989 • 78 citations

Apoptosis in brain-specific autoimmune disease

1995 • 64 citations

The surface expression of a tumor‐associated antigen on human kappa myeloma cells

1984 • 14 citations