Regulation and Development of Muscarinic Receptor Number and Function

THE AUTONOMIC NERVOUS SYSTEM

1903 • 1,674 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

1975 • 663 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Muscarinic acetylcholine receptors in developing chick heart

1977 • 177 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

External Imaging of Cerebral Muscarinic Acetylcholine Receptors

1984 • 154 citations

Ontogeny of muscarinic receptors in rat brain

1980 • 138 citations

Muscarinic supersensitivity induced by septal lesion or chronic atropine treatment

1981 • 132 citations

Trophic Interaction between Cloned Tissue Culture Lines of Nerve and Muscle

1971 • 129 citations

Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain

1979 • 122 citations

Scopolamine induces an increase in muscarinic receptor level in rat hippocampus

1980 • 120 citations

Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein

1985 • 119 citations

Cholinergic activity regulates muscarinic receptors in central nervous system cultures.

1979 • 117 citations

Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss

1979 • 111 citations

Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.

1986 • 110 citations

Regulation of adenylate cyclase activity mediated by muscarinic acetylcholine receptors.

1978 • 109 citations

The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.

1982 • 108 citations

Cardiac morphogenesis

2008 • 107 citations

In vivo regulation of muscarinic acetylcholine receptor number and function in embryonic chick heart.

1981 • 103 citations

Muscarinic acetylcholine receptors of the developing retina.

1977 • 102 citations

Alteration of muscarinic binding in specific brain areas following estrogen treatment

1982 • 101 citations

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

1987 • 98 citations

Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart

1985 • 95 citations

Amitriptyline: Long-term treatment elevates α-adrenergic and muscarinic receptor binding in mouse brain

1980 • 93 citations

Physical properties of the purified cardiac muscarinic acetylcholine receptor

1986 • 93 citations

Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation

1982 • 92 citations

Agonist and guanine nucleotide modulation of muscarinic cholinergic receptors in cultured heart cells.

1980 • 89 citations

Long-term regulation of muscarinic acetylcholine receptors on cultured nerve cells

1979 • 88 citations

Alterations in cardiac autonomic receptors following 6-hydroxydopamine treatment in rats.

1980 • 87 citations

Regulation of Muscarinic Acetylcholine Receptor Concentration in Cloned Neuroblastoma Cells

1980 • 87 citations

Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.

1985 • 85 citations

Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors

1985 • 83 citations

Purification of the muscarinic acetylcholine receptor from porcine atria.

1984 • 82 citations

Muscarinic cholinergic receptor in the human heart evidenced under physiological conditions by positron emission tomography.

1985 • 82 citations

Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.

1985 • 81 citations

Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development

1984 • 79 citations

Electrical stimulation of denervated muscles reduces incorporation of methionine into the ACh receptor

1977 • 79 citations

Axonal transport of muscarinic cholinergic receptors in rat vagus nerve: high and low affinity agonist receptors move in opposite directions and differ in nucleotide sensitivity

1982 • 77 citations

Rodent eccrine sweat glands: A case of multiple efferent innervation

1984 • 75 citations

Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function.

1985 • 75 citations

Selective breeding for differences in cholinergic function: Pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP

1984 • 75 citations

Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cells

1982 • 74 citations

Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium.

1985 • 71 citations

Monoclonal antibodies to purified muscarinic receptor display agonist-like activity.

1984 • 70 citations

Desensitization of the acetylcholine‐induced increase of potassium conductance in rabbit cardiac Purkinje fibres.

1986 • 69 citations

Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.

1986 • 68 citations

Dual mechanism for inhibition of calcium-dependent action potentials by acetylcholine in avian ventricular muscle. Relationship to cyclic AMP.

1980 • 67 citations

Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution

1986 • 67 citations

Short‐term disappearance of muscarinic cell surface receptors in carbachol‐induced desensitization

1983 • 61 citations

Muscarinic receptor binding in rat sympathetic ganglia is unaffected by denervation

1978 • 60 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. II. Long lived increase of adenylate cyclase activity mediated by alpha receptors.

1979 • 59 citations

Decrease or increase in cardiac muscarinic cholinergic receptor number in rats treated with methacholine or atropine

1980 • 55 citations

Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis

1986 • 53 citations

Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development

1987 • 52 citations

Analysis of muscarinic receptor concentration and subtypes following lesion of rat substantia innominata

1985 • 52 citations

Muscarinic receptor‐mediated increase in cytoplasmic free Ca²⁺in isolated bovine adrenal medullary cells

1985 • 52 citations

Presynaptic muscarinic cholinergic receptors

1978 • 51 citations

Regulation of the Muscarinic Acetylcholine Receptor: Effects of Phosphorylating Conditions on Agonist and Antagonist Binding

1983 • 51 citations

Cholinergic adaptations to chronic oxotremorine infusion.

1981 • 51 citations

Muscarinic cholinergic receptors in rat heart. Effects of thyroidectomy.

1977 • 50 citations

Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes

1979 • 49 citations

Kindled seizure‐induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: Evidence for localization to dentate granule cells

1983 • 48 citations

Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites.

1986 • 47 citations

Two molecular weight forms of muscarinic acetylcholine receptors in the avian central nervous system: switch in predominant form during differentiation of synapses.

1985 • 43 citations

Development of cholinergic markers in mouse forebrain. II. Muscarinic receptor binding in cortex

1985 • 43 citations

Denervation, supersensitivity and muscarinic receptors in the cat iris

1979 • 42 citations

Agonist-induced changes in the modulation of K+ permeability and beating rate by muscarinic agonists in cultured heart cells.

1982 • 41 citations

Desensitisation and agonist binding to cholinergic receptors in intestinal smooth muscle

1974 • 41 citations

Isolation and characterization of monoclonal antibodies specific for the cardiac muscarinic acetylcholine receptor

1987 • 40 citations

Involvement of the sodium-potassium pump in the mechanism of postjunctional supersensitivity of the vas deferens of the guinea pig.

1979 • 39 citations

Normal serum and lipoprotein-deficient serum give different expressions of excitability, corresponding to different stages of differentiation, in chicken cardiac cells in culture.

1982 • 39 citations

Temperature Dependence of Muscarinic Acetylcholine Receptor Activation, Desensitization, and Resensitization

1980 • 39 citations

Comparative properties of the in ovo and in vitro differentiation of the muscarinic cholinergic receptor in embryonic heart cells

1980 • 39 citations

The loss of muscarinic acetylcholine receptors in synaptic membranes under phosphorylating conditions is dependent on calmodulin

1981 • 38 citations

Differential ontogeny of putative M1 and M2 muscarinic receptor binding sites in the murine cerebral cortex and heart.

1985 • 38 citations

Molecular regulation of receptors: interaction of beta-estradiol and progesterone with the muscarinic system.

1981 • 37 citations

Agonist Regulation of Muscarinic Acetylcholine Receptors in Rat Spinal Cord

1982 • 37 citations

Regulation of Neuronal Muscarinic Acetylcholine Receptor Number by Protein Glycosylation

1986 • 37 citations

Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.

1980 • 35 citations

Changes in cholinergic parameters associated with failure of conotruncal septation in embryonic chick hearts after neural crest ablation.

1985 • 32 citations

Parallel Postnatal Development of Choline Acetyltransferase Activity and Muscarinic Acetylcholine Receptors in the Rat Olfactory Bulb

1986 • 32 citations

A possible role of synaptic‐membrane protein phosphorylation in the regulation of muscarinic acetylcholine receptors

1980 • 32 citations

Thyrotropin-releasing hormone increases the number of muscarinic receptors in the lateral septal area of the rat brain

1983 • 32 citations

Molecular alteration of a muscarinic acetylcholine receptor system during synaptogenesis.

1985 • 32 citations

Muscarinic receptors and responses in intact embryonic chick atrial and ventricular heart cells

1984 • 32 citations

Muscarinic receptor binding following cholinergic nerve lesions of the cingulate cortex and hippocampus of the rat

1981 • 31 citations

Specificity of Muscarinic Acetylcholine Receptor Regulation by Receptor Activity

1981 • 31 citations

Effect of chronic lithium on cholinergically mediated responses and [3H]QNB binding in rat brain

1985 • 30 citations

Biochemical and physical analyses of newly synthesized muscarinic acetylcholine receptors in cultured embryonic chicken cardiac cells

1986 • 29 citations

Regulation of muscarinic acetylcholine receptors and contractility of guinea pig vas deferens

1981 • 29 citations

Muscarinic receptor binding and oxidative enzyme activities in the adult rat superior cervical ganglion: effects of 6-hydroxydopamine and nerve growth factor

1983 • 28 citations

Muscarinic acetylcholine receptor regulation and protein phosphorylation in primary cultures of rat cerebellum

1981 • 28 citations

Comparison of muscarinic receptor properties in hatched chick heart atrium and ventricle.

1986 • 27 citations

Regulation of muscarinic acetylcholine receptor number in cultured neuronal cells by chronic membrane depolarization.

1987 • 27 citations

Cholinergic supersensitivity and decreased number of muscarinic receptors in atria from short-term diabetic rats

1984 • 26 citations

Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart

1985 • 26 citations

Muscarinic binding sites in the developing rabbit brain

1979 • 25 citations

Specific changes in the cholinergic system in guinea-pig vas deferens after denervation.

1980 • 25 citations

Carbachol induces desensitization of cardiac β-adrenergic receptors through muscarinic M1 receptors

1985 • 24 citations

Decreased Muscarinic Acetylcholine Receptor Number in the Central Nervous System of the Tottering (tg/tg) Mouse

1986 • 24 citations

The Muscarinic Receptor Adenylate Cyclase Complex of Rat Striatum: Desensitization Following Chronic Inhibition of Acetylcholinesterase Activity

1984 • 24 citations

Reactivity of chick embryo heart to cholinergic agonists during ontogenesis: decline in desensitization at the onset of cholinergic transmission.

1974 • 23 citations

Functional muscarinic supersensitivity in denervated rat hippocampus

1989 • 23 citations

Differential regulation of muscarinic and nicotinic receptors by cholinergic stimulation in cultured avian retina cells

1983 • 22 citations

Changes in acetylcholine and noradrenaline sensitivity of chick smooth muscle wholly innervated by sympathetic nerve during development

1975 • 22 citations

Decreased physiological sensitivity mediated by newly synthesized muscarinic acetylcholine receptors in embryonic chicken heart.

1984 • 22 citations

In vivo regulation of muscarinic cholinergic receptors in embryonic chick brain.

1982 • 22 citations

The development of physiologic responsiveness to muscarinic agonists in chick embryo heart cell cultures. Role of high affinity receptors and sensitivity to guanine nucleotides.

1984 • 21 citations

Muscarinic Binding Sites in Developing Normal and Mutant Mouse Cerebellum

1980 • 21 citations

Alterations in muscarinic cholinergic receptors after preganglionic denervation of the superior cervical ganglion in cats.

1983 • 21 citations

Functional and physical properties of chick atrial and ventricular GTP-binding proteins: relationship to muscarinic acetylcholine receptor-mediated responses.

1987 • 20 citations

Response of muscarinic cholinoceptors of guinea pig brain and ileum to chronic administration of carbamate or organophosphate cholinesterase inhibitors

1981 • 20 citations

Atropine-induced alterations of normal development of muscarinic receptors in the embryonic chick heart

1983 • 20 citations

Characterization of muscarinic cholinergic receptors in the submandibular gland of the rat

1985 • 18 citations

Influence of sympathetic nerves on development of responsiveness of the chick smooth muscle to drugs

1976 • 16 citations

THE EFFECTS OF NORADRENERGIC DENERVATION ON MUSCARINIC RECEPTORS OF SMOOTH MUSCLE

1982 • 16 citations

Muscarinic cholinergic receptors in mouse pituitary tumor cells: prolonged agonist pretreatment decreases receptor content and increases forskolin- and hormone-stimulated cyclic AMP synthesis and adrenocorticotropin secretion.

1985 • 14 citations

Decrease in muscarinic cholinergic response of the rat heart following treatment with 6-hydroxydopa

1979 • 13 citations

Neural regulation of muscarinic receptors in chick expansor secundariorum muscle

1982 • 13 citations

Rat cardiac muscarinic receptors. II. Influence of thyroid status and cardiac hypertrophy.

1982 • 13 citations

Effect of Tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo

1981 • 12 citations

Differences in the properties of muscarinic cholinergic receptors in the developing chick myocardium.

1985 • 12 citations

Muscarinic cholinergic receptors on cultured thyroid cells. I. Biological effect of carbachol and characterization of the receptors.

1982 • 11 citations

Acetylcholine supersensitivity in the rat heart produced by neonatal sympathectomy

1985 • 11 citations

Muscarinic cholinergic receptors on cultured thyroid cells. II. Carbachol-induced desensitization.

1982 • 10 citations

The effects of altered thyroid state upon responses mediated by atrial muscarinic receptors in the rat

1983 • 10 citations

Alteration in the regulation of neuronal muscarinic acetylcholine receptor number induced by chronic lithium in neuroblastoma cells

1988 • 10 citations

Metabolic changes in deafferented central neurons of an insect, Acheta domesticus. II. Effects on cholinergic binding sites and acetylcholinesterase

1986 • 9 citations

Partial agonist activity of oxotremorine at muscarinic acetylcholine receptors in the embryonic chick heart.

1984 • 8 citations

Effects of a chemical sympathectomy on cardiac muscarinic receptors in normotensive (WKY) and spontaneously hypertensive (SHR) rats

1983 • 7 citations

Muscarinic Acetylcholine Receptors in Neuroblastoma Cells: Lack of Effect of Veratrum Alkaloids on Receptor Number

1984 • 7 citations

Differential down-regulation by carbamylcholine of putative nicotinic and muscarinic acetylcholine receptor sites in chick retina cultures

1982 • 3 citations

Changes in cholinergic and adrenegic responses of organ-cultured chick smooth muscle

1980 • 3 citations

Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.

1986 • 3 citations