Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

1983 • 291 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties.

1982 • 235 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

PHOSPHATIDYLINOSITOL TURNOVER IN RECEPTOR MECHANISM AND SIGNAL TRANSDUCTION

1985 • 207 citations

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

1984 • 206 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells

1982 • 182 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Cholinergic activity regulates muscarinic receptors in central nervous system cultures.

1979 • 117 citations

Induction of expression and phosphorylation of the human interleukin 2 receptor by a phorbol diester.

1984 • 116 citations

Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss

1979 • 111 citations

The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.

1982 • 108 citations

In vivo regulation of muscarinic acetylcholine receptor number and function in embryonic chick heart.

1981 • 103 citations

Long-term regulation of muscarinic acetylcholine receptors on cultured nerve cells

1979 • 88 citations

Regulation of Muscarinic Acetylcholine Receptor Concentration in Cloned Neuroblastoma Cells

1980 • 87 citations

Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function.

1985 • 75 citations

Binding of Agonists and Antagonists to Muscarinic Acetylcholine Receptors on Intact Cultured Heart Cells

1983 • 52 citations

Receptor‐Mediated Increases in Phosphatidylinositol Turnover in Neuron‐Like Cell Lines

1983 • 41 citations

Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells

1984 • 29 citations

CALCIUM- AND LIPID-DEPENDENT PROTEIN PHOSPHORYLATION IN THE HUMAN OVARY

1983 • 29 citations

Muscarinic acetylcholine receptor regulation and protein phosphorylation in primary cultures of rat cerebellum

1981 • 28 citations

Glycosylation‐Dependent Regulation of Opiate (Enkephalin) Receptors in Neurotumor Cells

1983 • 18 citations