Metal Ion Stress in Yeast

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

1993 • 1,905 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Biochemical Effects of Mercury, Cadmium, and Lead

1972 • 1,464 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

1988 • 886 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

1994 • 660 citations

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake

1994 • 659 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Heat shock factor and the heat shock response

1991 • 615 citations

The structural chemistry of metal thiolate complexes

1986 • 611 citations

Heat shock proteins: molecular chaperones of protein biogenesis

1993 • 598 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

1992 • 525 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

Heat shock factor is regulated differently in yeast and HeLa cells

1987 • 489 citations

Mapping, cloning and genetic characterization of the region containing the Wilson disease gene

1993 • 489 citations

Refined crystal structure of ascorbate oxidase at 1.9 Å resolution

1992 • 457 citations

PHYTOCHELATINS

1990 • 437 citations

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake.

1995 • 431 citations

Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell

1994 • 423 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter.

1992 • 410 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.

1994 • 407 citations

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1989 • 392 citations

Glutathione, a first line of defense against cadmium toxicity

1987 • 388 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

1993 • 381 citations

Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein

1988 • 365 citations

Genetics and molecular biology of siderophore-mediated iron transport in bacteria

1989 • 364 citations

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

1994 • 364 citations

Complex Interactions Among Members of an Essential Subfamily of hsp70 Genes in Saccharomyces Cerevisiae

1987 • 358 citations

Evidence for Cu(II) Reduction as a Component of Copper Uptake by Saccharomyces cerevisiae

1995 • 357 citations

Tandem gene amplification mediates copper resistance in yeast.

1982 • 354 citations

Purification and characterization of a heat-shock element binding protein from yeast.

1987 • 348 citations

Refined crystal structure of Cd, Zn metallothionein at 2·0 Å resolution

1991 • 340 citations

Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

1992 • 336 citations

Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.

1992 • 335 citations

ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene.

1988 • 321 citations

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

1990 • 320 citations

The fungal vacuole: composition, function, and biogenesis.

1990 • 308 citations

Genetic Evidence that Ferric Reductase Is Required for Iron Uptake in Saccharomyces cerevisiae

1990 • 296 citations

Copper metallothionein of yeast, structure of the gene, and regulation of expression.

1984 • 283 citations

Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.

1984 • 279 citations

MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast.

1993 • 274 citations

Heat shock proteins: molecular chaperones of protein biogenesis.

1993 • 272 citations

Crystal Structure of the DNA Binding Domain of the Heat Shock Transcription Factor

1994 • 269 citations

Oxidants, inflammation, and anti‐inflammatory drugs

1988 • 267 citations

Molecular Characterization of a Putative Arabidopsis thaliana Copper Transporter and Its Yeast Homologue

1995 • 266 citations

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1993 • 261 citations

Iron metabolism in copper-deficient swine

1968 • 258 citations

Reactive species and their accumulation on radical-damaged proteins

1993 • 253 citations

Cooperative binding of drosophila heat shock factor to arrays of a conserved 5 bp unit

1991 • 250 citations

The emergence of the chaperone machines

1992 • 249 citations

Examining the function and regulation of hsp 70 in cells subjected to metabolic stress

1992 • 236 citations

Effects of histone H4 depletion on the cell cycle and transcription of Saccharomyces cerevisiae.

1988 • 225 citations

Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae.

1987 • 225 citations

Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.

1993 • 225 citations

Constitutive binding of yeast heat shock factor to DNA in vivo.

1988 • 221 citations

Function and Autoregulation of Yeast Copperthionein

1985 • 216 citations

Molecular Biology of Metallothionein Gene Expression

1987 • 214 citations

Metal-microbe interactions

1989 • 209 citations

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

1991 • 199 citations

Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae

1989 • 197 citations

Yeast bZip proteins mediate pleiotropic drug and metal resistance.

1993 • 191 citations

Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae.

1990 • 181 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

CRS5 encodes a metallothionein-like protein in Saccharomyces cerevisiae.

1994 • 173 citations

The yeast heat shock transcription factor contains a transcriptional activation domain whose activity is repressed under nonshock conditions

1990 • 172 citations

Sequence, mapping and disruption of CCC2, a gene that cross‐complements the Ca²⁺‐sensitive phenotype of csg1 mutants and encodes a P‐type ATPase belonging to the Cu²⁺‐ATPase subfamily

1995 • 166 citations

Genetics and molecular biology of siderophore-mediated iron transport in bacteria.

1989 • 161 citations

Yeast metallothionein function in metal ion detoxification.

1986 • 158 citations

Mutational analysis of yeast vacuolar H(+)-ATPase.

1991 • 152 citations

A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor.

1991 • 152 citations

Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata.

1988 • 141 citations

Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.

1994 • 140 citations

Isolation of mutants of Schizosaccharomycespombe unable to synthesize cadystin, small cadmium-binding peptides

1988 • 134 citations

The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.

1989 • 134 citations

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment.

1990 • 127 citations

Heat Shock-Mediated Cell Cycle Blockage and G1 Cyclin Expression in the Yeast Saccharomyces cerevisiae

1993 • 119 citations

Metal Ions in Fungi

2020 • 119 citations

Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.

1986 • 117 citations

A copper-thiolate polynuclear cluster in the ACE1 transcription factor.

1991 • 113 citations

The CUP2 Gene Product, Regulator of Yeast Metallothionein Expression, Is a Copper-Activated DNA-Binding Protein

1989 • 112 citations

Gene amplification in yeast: CUP1 copy number regulates copper resistance

1983 • 108 citations

Enhanced Effectiveness of Copper Ion Buffering by CUP1 Metallothionein Compared with CRS5 Metallothionein in Saccharomyces cerevisiae

1996 • 105 citations

The vacuolar H+-ATPase of Saccharomyces cerevisiae is required for efficient copper detoxification, mitochondrial function, and iron metabolism

1993 • 102 citations

Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

1991 • 101 citations

A cysteine-rich nuclear protein activates yeast metallothionein gene transcription.

1989 • 98 citations

Ubiquitin-dependent protein degradation: a cellular perspective

1992 • 96 citations

Saccharomyces cerevisiae and Neurospora crassa contain heavy metal sequestering phytochelatin

1992 • 96 citations

Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae.

1993 • 92 citations

An iron deficiency-specific cDNA from barley roots having two homologous cysteine-rich MT domains

1991 • 90 citations

Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences.

1989 • 90 citations

Effects of copper on mammalian cell components

1989 • 89 citations

Short Peptide Fragments Derived from HMG-I/Y Proteins Bind Specifically to the Minor Groove of DNA

1994 • 88 citations

Construction of Zn2+/Cd2+ hypersensitive cyanobacterial mutants lacking a functional metallothionein locus.

1993 • 87 citations

The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein.

1989 • 85 citations

Ubiquitin and intracellular protein degradation

1992 • 84 citations

Molecular Biology of Iron Transport in Fungi

2020 • 81 citations

The Hepta(μ-benzenethiolato)pentametallate(I) dianions of copper and silver: Formation and crystal structures

1978 • 76 citations

Nucleosome loss activates CUP1 and HIS3 promoters to fully induced levels in the yeast Saccharomyces cerevisiae.

1992 • 75 citations

Temperature-dependent regulation of a heterologous transcriptional activation domain fused to yeast heat shock transcription factor.

1992 • 75 citations

Establishment of the metal-to-cysteine connectivities in silver-substituted yeast metallothionein

1991 • 75 citations

The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.

1994 • 71 citations

Heat shock transcription factor activates transcription of the yeast metallothionein gene.

1991 • 70 citations

General principles of biochemistry of the elements

1987 • 69 citations

The cell cycle then and now

1992 • 69 citations

Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids

1981 • 67 citations

Regulation of metallothionein genes by the ACE1 and AMT1 transcription factors

1993 • 66 citations

Expression of a Yeast Metallothionein Gene Family Is Activated by a Single Metalloregulatory Transcription Factor

1992 • 66 citations

Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification.

1993 • 60 citations

Mutated Yeast Heat Shock Transcription Factor Exhibits Elevated Basal Transcriptional Activation and Confers Metal Resistance

1995 • 60 citations

Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata.

1990 • 59 citations

Yeast heat shock transcription factor contains a flexible linker between the DNA-binding and trimerization domains. Implications for DNA binding by trimeric proteins.

1994 • 59 citations

Gene Control of Copper-Sensitivity in Saccharomyces

1955 • 59 citations

The DNA and Cu binding functions of ACE1 are interdigitated within a single domain.

1990 • 58 citations

Identification of SLF1 as a New Copper Homeostasis Gene Involved in Copper Sulfide Mineralization in Saccharomyces cerevisiae

1996 • 57 citations

Copper uptake in wild type and copper metallothionein-deficient Saccharomyces cerevisiae. Kinetics and mechanism.

1990 • 55 citations

General Principles of Biochemistry of the Elements

1987 • 52 citations

<scp>II</scp>. Yeast sequencing reports. A putative P‐type Cu²⁺‐transporting ATPase gene on chromosome II of Saccharomyces cerevisiae

1994 • 51 citations

Characterization of denatured protein inducers of the heat shock (stress) response in Xenopus laevis oocytes.

1994 • 50 citations

Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract.

1989 • 50 citations

Presence of a Copper(I)−Thiolate Regulatory Domain in the Copper-Activated Transcription Factor Amt1

1996 • 48 citations

Identification of the Zn(II) Site in the Copper-Responsive Yeast Transcription Factor, AMT1: A Conserved Zn Module

1996 • 45 citations

Metal-Specific Posttranscriptional Control of Human Metallothionein Genes

1989 • 45 citations

An electronmicroscopic study on copper precipitation by copper-resistant yeast cells

1963 • 44 citations

Mixed Cu+ and Zn2+ Coordination in the DNA-Binding Domain of the AMT1 Transcription Factor from Candida glabrata

1994 • 44 citations

The half-life of mRNA in Saccharomyces cerevisiae

1979 • 44 citations

A single amino acid change in CUP2 alters its mode of DNA binding.

1990 • 43 citations

Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor.

1992 • 41 citations

Distinct Regions of Cu(I)·ACE1 Contact Two Spatially Resolved DNA Major Groove Sites

1995 • 39 citations

Role of Heat Shock Transcription Factor in Yeast Metallothionein Gene Expression

1991 • 38 citations

hsc70 moderates the heat shock (stress) response in Xenopus laevis oocytes and binds to denatured protein inducers.

1994 • 37 citations

A distal heat shock element promotes the rapid response to heat shock of the HSP26 gene in the yeast Saccharomyces cerevisiae.

1993 • 37 citations

Structural and functional studies of the amino terminus of yeast metallothionein.

1987 • 35 citations

Metal-specific posttranscriptional control of human metallothionein genes.

1989 • 34 citations

Isolation and characterization of glutathione biosynthesis-deficient mutants in Saccharomyces cerevisiae.

1990 • 33 citations

Genetic and biochemical analysis of glutathione-deficient mutants of Saccharomyces cerevisiae

1990 • 31 citations

Disruption analysis of metallothionein-encoding genes in Candida glabrata

1992 • 30 citations

Identification and Analysis of a Saccharomyces cerevisiae Copper Homeostasis Gene Encoding a Homeodomain Protein

1994 • 30 citations

Distinct metal binding configurations in ACE1

1993 • 28 citations

Role of heat shock transcription factor in yeast metallothionein gene expression.

1991 • 27 citations

Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein.

1994 • 26 citations

STUDIES ON THE PATHWAY OF SULFIDE PRODUCTION IN A COPPER-ADAPTED YEAST

1965 • 23 citations

Dominance of metallothionein in metal ion buffering in yeast capable of synthesis of (gamma EC)nG isopeptides.

1994 • 21 citations

Different Induction of 70,000-Da Heat Shock Protein and Metallothionein in HeLa Cells by Copper1

1991 • 19 citations

Resistance to cadmium is under the control of the CAD2 gene in the yeast Saccharomyces cerevisiae

1990 • 15 citations

Protection against cadmium toxicity in yeast by alcohol dehydrogenase

1991 • 15 citations

Analysis of copper‐induced metallothionein expression using autonomously replicating plasmids in Candida glabrata

1995 • 15 citations

The metallothionein structural motif in gene expression.

1994 • 14 citations

A new family of polymorphic metallothionein-encoding genes MTH1 (CUP1) and MTH2 in Saccharomyces cerevisiae

1992 • 8 citations

Role of the conserved histidines in the Zn module of the copper-activated transcription factors in yeast

1996 • 7 citations