Ubiquitin-dependent protein degradation: a cellular perspective

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

The N-End Rule in Bacteria

1991 • 536 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

Ubiquitination

1991 • 430 citations

The degradation signal in a short-lived protein

1989 • 427 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway

1991 • 316 citations

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.

1991 • 281 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

Ubiquitin as a degradation signal.

1992 • 261 citations

Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.

1987 • 255 citations

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

1990 • 243 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

1990 • 184 citations

The prosome: an ubiquitous morphologically distinct RNP particle associated with repressed mRNPs and containing specific ScRNA and a characteristic set of proteins.

1984 • 180 citations

The protein substrate binding site of the ubiquitin-protein ligase system.

1986 • 178 citations

The ubiquitin pathway for protein degradation

1991 • 170 citations

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

1988 • 161 citations

UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.

1990 • 160 citations

Genetic analysis of the ubiquitin system

1991 • 158 citations

Cis-trans recognition and subunit-specific degradation of short-lived proteins

1990 • 150 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae.

1988 • 139 citations

The Drosophila proteasome undergoes changes in its subunit pattern during development

1989 • 127 citations

How are substrates recognized by the ubiquitin-mediated proteolytic system

1989 • 125 citations

Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme.

1991 • 115 citations

Eukaryotic pre-tRNA 5′ processing nuclease: Copurification with a complex cylindrical particle

1986 • 106 citations

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

1991 • 101 citations

Molecular cloning and functional analysis of three subunits of yeast proteasome.

1991 • 97 citations

The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae.

1990 • 88 citations

Genes homologous to ubiquitin-conjugating proteins and eukaryotic transcription factor SII in African swine fever virus

1992 • 88 citations

Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation.

1992 • 75 citations

Ubiquitin-mediated degradation of histone H3 does not require the substrate-binding ubiquitin protein ligase, E3, or attachment of polyubiquitin chains.

1990 • 75 citations

A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin.

1985 • 70 citations

Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.

1990 • 69 citations

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs.

1991 • 65 citations

Expression of theSaccharomyces cerevisiaeDNA repair geneRAD6that encodes a ubiquitin conjugating enzyme, increases in response to DNA damage and in meiosis but remains constant during the mitotic cell cycle

1990 • 63 citations

A ubiquitin conjugating enzyme encoded by African swine fever virus.

1992 • 54 citations

Cloning and characterization of a Saccharomyces cerevisiae gene encoding a new member of the ubiquitin-conjugating protein family

1991 • 50 citations

Separation of yeast proteasome subunits

1989 • 40 citations

Molecular interaction of the proteasome (multicatalytic proteinase). Evidence that the proteasome is not a constituent of the ‘26 S’ multienzyme complex

1991 • 24 citations