Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Heat shock factor and the heat shock response

1991 • 615 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Key features of heat shock regulatory elements.

1988 • 566 citations

Stress protein systems of mammalian cells

1986 • 564 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels

1982 • 542 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Heat shock factor is regulated differently in yeast and HeLa cells

1987 • 489 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Characterization of the thermotolerant cell. I. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression.

1988 • 399 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Purification of the major mammalian heat shock proteins.

1982 • 369 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

1987 • 343 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.

1985 • 327 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

Activation in vitro of sequence-specific DNA binding by a human regulatory factor

1988 • 278 citations

Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

1987 • 232 citations

Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonucleoprotein complexes.

1988 • 195 citations

Key Features of Heat Shock Regulatory Elements

1988 • 189 citations

Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.

1985 • 164 citations

Structure and Expression of the Human Gene Encoding Major Heat Shock Protein HSP70

1985 • 155 citations

Inhibition of heat shock (stress) protein induction by deuterium oxide and glycerol: Additional support for the abnormal protein hypothesis of induction

1989 • 143 citations

Complex modes of heat shock factor activation.

1990 • 141 citations

Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae.

1990 • 127 citations

Purified human factor activates heat shock promoter in a HeLa cell-free transcription system.

1988 • 106 citations

Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides

1985 • 104 citations

Cis-acting elements involved in the regulated expression of a human hsp70 gene

1988 • 67 citations

Transport and assembly processes in the endoplasmic reticulum.

1990 • 61 citations

Complex Modes of Heat Shock Factor Activation

1990 • 47 citations

Self-Regulation of 70-Kilodalton Heat Shock Proteins in Saccharomyces cerevisiae

1990 • 27 citations

The heat shock genes: A family of highly conserved genes with a superbly complex expression pattern

1984 • 25 citations