MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast.

METALLOTHIONEIN

1986 • 1,606 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions

1986 • 623 citations

A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions.

1993 • 470 citations

Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein

1988 • 365 citations

Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.

1992 • 335 citations

ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene.

1988 • 321 citations

Genetic Evidence that Ferric Reductase Is Required for Iron Uptake in Saccharomyces cerevisiae

1990 • 296 citations

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1993 • 261 citations

The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.

1989 • 134 citations

Reductive and Non-reductive Mechanisms of Iron Assimilation by the Yeast Saccharomyces cerevisiae

1989 • 127 citations

The CUP2 Gene Product, Regulator of Yeast Metallothionein Expression, Is a Copper-Activated DNA-Binding Protein

1989 • 112 citations

Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

1991 • 101 citations

A cysteine-rich nuclear protein activates yeast metallothionein gene transcription.

1989 • 98 citations

Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences.

1989 • 90 citations

[2] Elimination of a metals

1988 • 86 citations

Cooperative activation of a eukaryotic transcription factor: interaction between Cu(I) and yeast ACE1 protein.

1989 • 86 citations

ACE1 Regulates Expression of the Saccharomyces cerevisiae Metallothionein Gene

1988 • 71 citations

Expression of a Yeast Metallothionein Gene Family Is Activated by a Single Metalloregulatory Transcription Factor

1992 • 66 citations

The DNA and Cu binding functions of ACE1 are interdigitated within a single domain.

1990 • 58 citations

Isolation of the catalase T structural gene of Saccharomyces cerevisiae by functional complementation.

1983 • 57 citations

Copper uptake in wild type and copper metallothionein-deficient Saccharomyces cerevisiae. Kinetics and mechanism.

1990 • 55 citations

A Cysteine-Rich Nuclear Protein Activates Yeast Metallothionein Gene Transcription

1989 • 45 citations

A single amino acid change in CUP2 alters its mode of DNA binding.

1990 • 43 citations

Cloning the Menkes disease gene

1993 • 24 citations

Isolation of the Catalase T Structural Gene of Saccharomyces cerevisiae by Functional Complementation

1983 • 15 citations

A Single Amino Acid Change in CUP2 Alters Its Mode of DNA Binding

1990 • 9 citations