Towards Gene-Inhibition Therapy: A Review of Progress and Prospects in the Field of Antiviral Antisense Nucleic Acids and Ribozymes

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

On Finding All Suboptimal Foldings of an RNA Molecule

1989 • 2,019 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1990 • 1,270 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

1981 • 877 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

Improved predictions of secondary structures for RNA.

1989 • 822 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

An unwinding activity that covalently modifies its double-stranded RNA substrate

1988 • 702 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum

1987 • 677 citations

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

1990 • 663 citations

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

1987 • 660 citations

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1990 • 638 citations

Autolytic Processing of Dimeric Plant Virus Satellite RNA

1986 • 625 citations

Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid

1986 • 583 citations

Inhibition of thymidine kinase gene expression by anti-sense RNA: A molecular approach to genetic analysis

1984 • 558 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members.

1983 • 510 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

A self-splicing RNA excises an intron lariat

1986 • 449 citations

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

1988 • 445 citations

A c- myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro

1988 • 439 citations

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1990 • 437 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

1988 • 425 citations

Intracellular immunization

1988 • 420 citations

Injected anti-sense RNAs specifically block messenger RNA translation in vivo.

1985 • 410 citations

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

1986 • 403 citations

[20] Computer prediction of RNA structure

1989 • 387 citations

Antigenomic RNA of human hepatitis delta virus can undergo self-cleavage

1988 • 385 citations

[17] Predicting optimal and suboptimal secondary structure for RNA

1990 • 383 citations

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.

1987 • 381 citations

The case for an ancestral genetic system involving simple analogues of the nucleotides.

1987 • 375 citations

Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

1988 • 374 citations

Defining the Inside and Outside of a Catalytic RNA Molecule

1989 • 368 citations

RNA catalytic properties of the minimum (-)sTRSV sequence

1989 • 360 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro

1986 • 346 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA

1985 • 334 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site

1987 • 323 citations

Non-enzymatic cleavage and ligation of RNAs complementary to a plant virus satellite RNA

1986 • 321 citations

An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

1989 • 305 citations

External Guide Sequences for an RNA Enzyme

1990 • 303 citations

Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.

1989 • 296 citations

A site-specific self-cleavage reaction performed by a novel RNA in neurospora mitochondria

1990 • 292 citations

Human hepatitis delta virus RNA subfragments contain an autocleavage activity.

1989 • 284 citations

Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.

1989 • 270 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

1979 • 263 citations

Phenocopies induced with antisense RNA identify the wingless gene

1987 • 259 citations

Nuclear-organelle interactions: Nuclear antisense gene inhibits ribulose bisphosphate carboxylase enzyme levels in transformed tobacco plants

1988 • 252 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

Calmodulin is required for cell-cycle progression during G1 and mitosis.

1989 • 248 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

A model for the RNA-catalyzed replication of RNA.

1986 • 237 citations

Self-cleaving transcripts of satellite DNA from the newt

1987 • 237 citations

‘Hairpin’ catalytic RNA model: evidence for helices and sequence requirement for substrate RNA

1990 • 232 citations

RNA-catalysed synthesis of complementary-strand RNA

1989 • 228 citations

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

1988 • 227 citations

Phenocopy of discoidin I-minus mutants by antisense transformation in Dictyostelium

1985 • 225 citations

Ribozyme mediated destruction of RNA in vivo.

1989 • 223 citations

Multiple exon-binding sites in class II self-splicing introns

1987 • 218 citations

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

1986 • 211 citations

Production of phenocopies by Krüppel antisense RNA injection into Drosophila embryos

1985 • 210 citations

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

1989 • 207 citations

Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.

1985 • 204 citations

Circular RNAs: relics of precellular evolution?

1989 • 200 citations

Self-splicing of group II introns in vitro: Mapping of the branch point and mutational inhibition of lariat formation

1986 • 197 citations

c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.

1988 • 195 citations

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.

1990 • 194 citations

Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

1989 • 193 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg.

1989 • 182 citations

Antisense RNA and DNA

1990 • 181 citations

Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor.

1990 • 177 citations

Group II intron self-splicing. Alternative reaction conditions yield novel products.

1988 • 175 citations

Molecular genetics of group I introns: RNA structures and protein factors required for splicing — a review

1988 • 174 citations

Antisense RNA Directed Against the 3′ Noncoding Region Prevents Dormant mRNA Activation in Mouse Oocytes

1988 • 174 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

BIOLOGICAL REGULATION BY ANTISENSE RNA IN PROKARYOTES

1988 • 171 citations

Specific gene suppression by engineered ribozymes in monkey cells.

1989 • 171 citations

Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides

1989 • 169 citations

Satellite tobacco ringspot virus RNA: A subset of the RNA sequence is sufficient for autolytic processing

1986 • 157 citations

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

1990 • 157 citations

The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos

1990 • 156 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Transcriptional control of the endogenous MYC protooncogene by antisense RNA.

1987 • 153 citations

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

1990 • 151 citations

Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication.

1990 • 151 citations

Self-splicing of yeast mitochondrial ribosomal and messenger RNA precursors

1985 • 149 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation.

1991 • 139 citations

Structure–function relationships in eukaryotic nuclei

1991 • 138 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Protection against tobacco mosaic virus in transgenic plants that express tobacco mosaic virus antisense RNA.

1989 • 134 citations

Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates.

1988 • 132 citations

Techniques for using antisense oligodeoxyribonucleotides to study gene expression

1988 • 130 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.

1990 • 129 citations

Rna catalysis and the origin of life

1985 • 128 citations

Design of RNA enzymes distinguishing a single base mutation in RNA

1989 • 126 citations

Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.

1985 • 124 citations

Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression — a review

1988 • 123 citations

Role of matrix protein in cytopathogenesis of vesicular stomatitis virus

1990 • 121 citations

Specific inhibition of c-myc protein biosynthesis using an antisense synthetic deoxy-oligonucleotide in human T lymphocytes.

1988 • 119 citations

Control of replication of plasmid R1: kinetics of in vitro interaction between the antisense RNA, CopA, and its target, CopT.

1988 • 118 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Intermolecular exon ligation of the rRNA precursor of tetrahymena: Oligonucleotides can function as 5′ exons

1985 • 114 citations

Multiple self-splicing introns in bacteriophage T4: Evidence from autocatalytic GTP labeling of RNA in vitro

1986 • 113 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

ColE1 replication control circuitry: Sense from antisense

1988 • 111 citations

RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron.

1989 • 110 citations

Inhibition of heat shock protein synthesis by heat-inducible antisense RNA.

1986 • 105 citations

Naturally occurring antisense RNA control — a brief review

1988 • 105 citations

The cyclin B2 component of MPF is a substrate for the c-mosxe proto-oncogene product

1990 • 105 citations

Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript

1986 • 105 citations

A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus‐specific proteins in MDCK cells

1990 • 103 citations

Stereochemical Course of Catalysis by the Tetrahymena Ribozyme

1989 • 99 citations

Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena.

1987 • 99 citations

The tymobox, a sequence shared by most tymoviruses: its use in molecular studies of tymoviruses

1990 • 99 citations

Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives

1989 • 98 citations

Group II intron domain 5 facilitates a trans-splicing reaction.

1988 • 95 citations

Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines.

1990 • 95 citations

Sequence conservation and divergence of hepatitis δ virus RNA

1990 • 92 citations

A catalytic 13-mer ribozyme

1989 • 92 citations

Mutagenesis analysis of a self-cleaving RNA

1989 • 91 citations

RNA splicing in Neurospora mitochondria

1985 • 90 citations

Antisense Myc sequences induce differentiation of F9 cells.

1988 • 90 citations

Antisense RNA inhibits splicing of pre-mRNA in vitro.

1988 • 89 citations

Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA

1991 • 88 citations

The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site.

1990 • 88 citations

Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides

1990 • 87 citations

Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene

1988 • 85 citations

CBP2 protein promotes in vitro excision of a yeast mitochondrial group I intron.

1989 • 85 citations

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

1990 • 85 citations

Abnormal development and dye coupling produced by antisense RNA to gap junction protein in mouse preimplantation embryos.

1989 • 85 citations

Antisense RN

1990 • 85 citations

The IS10 transposase mRNA is destabilized during antisense RNA control.

1990 • 84 citations

Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication.

1990 • 83 citations

Studies on the hammerhead RNA self-cleaving domain

1989 • 81 citations

Reversible Cleavage and Ligation of Hepatitis Delta Virus RNA

1989 • 81 citations

Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA

1990 • 80 citations

Antisence RNA inhibits expression of membrane skeleton protein 4.1 during embryonic development of xenopus

1988 • 79 citations

An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein.

1989 • 79 citations

Anti-sense RNA efficiently inhibits formation of the 10 kd polypeptide of photosystem II in transgenic potato plants: analysis of the role of the 10 kd protein.

1990 • 78 citations

Efficient Trans-Splicing of a Yeast Mitochondrial RNA Group II Intron Implicates a Strong 5′ Exon-Intron Interaction

1986 • 77 citations

A 3′ splice site-binding sequence in the catalytic core of a group I intron

1990 • 75 citations

Function of micF as an antisense RNA in osmoregulatory expression of the ompF gene in Escherichia coli

1987 • 75 citations

Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro.

1989 • 74 citations

Inhibition of Human Immunodeficiency Virus Type 1-mediated Cytopathic Effects by Poly(L-lysine)-conjugated Synthetic Antisense Oligodeoxyribonucleotides

1989 • 74 citations

Surface cAMP receptors mediate multiple responses during development in Dictyostelium: evidenced by antisense mutagenesis.

1990 • 74 citations

Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity

1989 • 73 citations

Sequence-dependent structural variations of hammerhead RNA enzymes

1990 • 69 citations

Ribozymes that cleave an RNA sequence from human immunodeficiency virus: The effect of flanking sequence on rate

1991 • 66 citations

The 7S RNA from tomato leaf tissue resembles a signal recognition particle RNA and exhibits a remarkable sequence complementarity to viroids.

1988 • 65 citations

Antisense DNA and RNA: progress and prospects.

1988 • 65 citations

Phosphorothioate Oligodeoxynucleotides Are Potent Sequence Nonspecific Inhibitors of De Novo Infection by HIV

1989 • 63 citations

The inhibition of neunte outgrowth in PC12 cells by tubulin antisense oligodeoxyribonucleotides

1988 • 63 citations

Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.

1987 • 60 citations

Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence

1987 • 60 citations

Synthetic interferon inducers

2007 • 59 citations

Stable repression of ribosomal protein L1 synthesis in Xenopus oocytes by microinjection of antisense RNA.

1986 • 59 citations

Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron

1990 • 57 citations

Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.

1990 • 57 citations

A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

1989 • 56 citations

Catalysis of splicing-related reactions between dinucleotides by a ribozyme

1987 • 56 citations

An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme

1990 • 55 citations

Target dependence of antisense oligodeoxynucleotide inhibition of c-Ha-ras p21 expression and focus formation in T24-transformed NIH3T3 cells.

1990 • 55 citations

Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.

1989 • 54 citations

Control of gene expression in bacteriophage P22 by a small antisense RNA. I. Characterization in vitro of the Psar promoter and the sar RNA transcript.

1987 • 53 citations

tcRNA as a naturally occurring antisense RNA in eukaryotes

1986 • 53 citations

Self cleavage of a precursor RNA from bacteriophage T4

1984 • 51 citations

Antisense RNA inhibits endogenous gene expression in mouse preimplantation embryos: lack of double-stranded RNA "melting" activity.

1988 • 51 citations

The c4 repressors of bacteriophages P1 and P7 are antisense RNAs

1990 • 51 citations

RNA conformational requirements of self-cleavage of hepatitis delta virus RNA.

1990 • 49 citations

Self-splicing of group II introns in vitro: Lariat formation and 3′ splice site selection in mutant RNAs

1987 • 49 citations

Antisense ribosomal protein gene expression specifically disrupts oogenesis in Drosophila melanogaster.

1988 • 49 citations

Post-transcriptional events are responsible for low expression of myelin basic protein in myelin deficient mice: role of natural antisense RNA.

1990 • 49 citations

Inhibition of retroviral replication by anti-sense RNA.

1986 • 47 citations

RNA transcripts of the human immunodeficiency virus transactivation response element can inhibit action of the viral transactivator.

1990 • 47 citations

Antisense RNA complementary to 3' coding and noncoding sequences of creatine kinase is a potent inhibitor of translation in vivo.

1989 • 46 citations

Structures Involved in Tetrahymena rRNA Self-splicing and RNA Enzyme Activity

1987 • 46 citations

Loss of tumorigenic potential by human lung tumor cells in the presence of antisense RNA specific to the ectopically synthesized alpha subunit of human chorionic gonadotropin.

1989 • 46 citations

Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.

1989 • 45 citations

Tat-regulated production of multimerized TAR RNA inhibits HIV-1 gene expression.

1991 • 45 citations

Both RNA level and translation efficiency are reduced by anti-sense RNA in transgenic tobacco

1989 • 45 citations

Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA

1989 • 44 citations

Catalysis by the RNA subunit of RNase P — a minireview

1989 • 44 citations

Specific inhibition of human immunodeficiency virus type 1 replication by RNA transcribed in sense and antisense orientation from the 5′-leader/gag region

1990 • 43 citations

Sense and antisense transcription of bacteriophage T4 gene 32

1987 • 42 citations

Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones.

1988 • 42 citations

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.

1989 • 42 citations

Expression of c-fos antisense RNA inhibits the differentiation of F9 cells to parietal endoderm

1988 • 40 citations

Inhibition of heterologous strains of HIV by antisense RNA

1991 • 40 citations

Subcellular localization of low-abundance human immunodeficiency virus nucleic acid sequences visualized by fluorescence in situ hybridization.

1990 • 40 citations

Inhibition of SV40 replicon function by engineered antisense RNA transcribed by RNA polymerase III.

1987 • 39 citations

Regiospecific inhibition of DNA duplication by antisense phosphate-methylated oligodeoxynucleotides

1989 • 39 citations

Inhibition of Ly-6A antigen expression prevents T cell activation.

1990 • 39 citations

Site-directed mutagenesis of core sequence elements 9R', 9L, 9R, and 2 in self-splicing Tetrahymena pre-rRNA.

1987 • 39 citations

Gene therapy in perspective

1991 • 38 citations

Inhibition of Rous sarcoma virus replication by antisense RNA

1987 • 37 citations

Interlocked RNA circle formation by a self-splicing yeast mitochondrial group I intron

1987 • 36 citations

Repression of nicotinic acetylcholine receptor expression by antisense RNAs and an oligonucleotide.

1988 • 36 citations

The maternal store of the xlgv7 mRNA in full-grown oocytes is not required for normal development in Xenopus

1989 • 36 citations

Antisense RNA to the C-fos gene: Restoration of density-dependent growth arrest in a transformed cell line

1987 • 35 citations

Suppression of endo B cytokeratin by its antisense RNA inhibits the normal coexpression of endo A cytokeratin.

1987 • 34 citations

Anti-mRNAs in La Crosse bunyavirus-infected cells

1990 • 34 citations

Antisense RNA production in transgenic mice

1990 • 33 citations

The effect of antisense RNA to fibronectin on the malignancy of hybrids between melanoma cells and normal fibroblasts

1989 • 31 citations

The role of the c-fms oncogene in the regulation of HL-60 cell differentiation.

1990 • 30 citations

Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

1990 • 27 citations

Retinoid receptor antisense DNAs inhibit alkaline phosphatase induction and clonogenicity in malignant keratinocytes.

1989 • 27 citations

Self-splicing of a group II intron in yeast mitochondria: dependence on 5′ exon sequences.

1987 • 27 citations

Constitutive expression of c-fos antisense RNA blocks c-fos gene induction by interferon and by phorbol ester and reduces c-myc expression in F9 embryonal carcinoma cells.

1988 • 27 citations

Modulation of HLA class II antigen expression by transfection of sense and antisense DR alpha cDNA.

1989 • 26 citations

Analysis of a transformed cell line using antisense c-fos RNA

1988 • 26 citations

Control of gene expression by oligonucleotides covalently linked to intercalating agents

1989 • 25 citations

Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes

1990 • 24 citations

The conditional inhibition of gene expression in culturedDrosophilacells by antisense RNA

1989 • 23 citations

The self-splicing intron in theNeurosporaapocytochrome b gene contains a long reading frame in frame with the upstream exon

1988 • 23 citations

Effect of deletions at structural domains of group II intron bI1 on self-splicing in vitro

1990 • 23 citations

Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon‐inducible gene

1988 • 23 citations

Silkmoth chorion antisense RNA

1990 • 22 citations

Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule

1987 • 22 citations

Alpha-actinin synthesis can be modulated by antisense probes and is autoregulated in non-muscle cells.

1989 • 22 citations

Gene expression from both intronless and intron-containing Rous sarcoma virus clones is specifically inhibited by anti-sense RNA.

1985 • 22 citations

Rearrangements of viral and cellular DNA are often associated with expression of Rous sarcoma virus in rat cells

1985 • 21 citations

[40] Interferon inducers: General survey and classification

1981 • 21 citations

The intron of the yeast actin gene contains the promoter for an antisense RNA

1990 • 20 citations

Sequence specificity of the P6 pairing for splicing of the group Itdintron of phage T4

1989 • 20 citations

Expression of antisense RNA fails to inhibit influenza virus replication

1989 • 19 citations

Transcription of the sulA‐ompA region of Escherichia Coli during the SOS response and the role of an antisense RNA molecule

1989 • 18 citations

Expression of injected HPRT minigene DNA in mouse embryos and its inhibition by antisense DNA

1988 • 18 citations

Sequence requirements for branch formation in a group ll self-splicing lntron

1989 • 18 citations

An anti-sense c-erbA clone inhibits thyroid hormone-induced expression from the alpha-myosin heavy chain promoter.

1990 • 15 citations

Antisense RNA inhibition of HPRT synthesis

1990 • 15 citations

Translational control by antisense RNA in control of plasmid replication

1988 • 15 citations

Inhibition of adenovirus 5 replication in COS-1 cells by antisense RNAs against the viral E1a region

1989 • 14 citations

Catalytic activity of the nucleic acid component of the 1,4-α-glucan branching enzyme from rabbit muscles

1987 • 13 citations

Specific antisense RNA inhibition of growth hormone production in differentiated rat pituitary tumour cells

1990 • 11 citations

Use of antisense RNA to help identify a genomic clone for the 5′ region of mouse β-glucuronidase

1989 • 11 citations

The mechanism of group I self-splicing: an internal guide sequence can be provided in trans.

1990 • 11 citations

Reduction of N-myc expression by antisense RNA is amplified by interferon: Possible involvement of the 2-5A system

1990 • 10 citations

Reduction of EGF receptor synthesis by antisense RNA vectors

1986 • 10 citations

Studying pre-mRNA splicing using antisense 2-OMe RNA oligonucleotides

1990 • 9 citations

Reduction of EGF receptor levels in human tumor cells transfected with an antisense RNA expression vector

1989 • 9 citations

Specificity for 3′,5′-linked substrates in RNA-catalyzed RNA polymerization

1989 • 7 citations

Derepression of conjugal transfer of the antibiotic resistance plasmid R100 by antisense RNA

1989 • 7 citations

Characterization of the mode of binding of substrates to the active site of Tetrahymena self-splicing RNA using 5-fluorouracil-substituted mini-exons

1989 • 7 citations

c-fos antisense RNA blocks expression of c-fos gene in F9 embryonal carcinoma cells

1988 • 7 citations

Implications of Intermolecularly Catalyzed Reactions by the Tetrahymena Ribozyme

1987 • 5 citations

Gene Therapy for AIDS

1991 • 2 citations