An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle.

1975 • 569 citations

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation.

1988 • 476 citations

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

1988 • 425 citations

Oligodeoxynucleotides as inhibitors of gene expression: a review.

1988 • 419 citations

DIFFERENTIATION OF NEUROBLASTOMA CELLS IN CULTURE

1975 • 334 citations

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 286 citations

Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.

1986 • 275 citations

Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells.

1986 • 254 citations

The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.

1987 • 223 citations

Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase.

1988 • 212 citations

A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase.

1986 • 206 citations

Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase.

1983 • 177 citations

Photoaffinity labeling of a protein kinase from bovine brain with 8-azidoadenosine 3',5'-monophosphate

1975 • 162 citations

Techniques for using antisense oligodeoxyribonucleotides to study gene expression

1988 • 130 citations

Molecular Cloning, Complementary Deoxyribonucleic Acid Structure and Predicted Full-Length Amino Acid Sequence of the Hormone-lnducible Regulatory Subunit of 3′-5′-Cyclic Adenosine Monophosphate-Dependent Protein Kinase from Human Testis

1988 • 124 citations

Cyclic nucleotides in cultured cells.

1975 • 122 citations

Cell differentiation and bypassing of genetic defects in the suppression of malignancy.

1987 • 118 citations

Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination

1985 • 115 citations

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

1985 • 113 citations

Probable involvement of both intrachain cAMP binding sites in activation of protein kinase.

1983 • 106 citations

Human factor VIII:C purified using monoclonal antibody to von Willebrand factor.

1988 • 105 citations

Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis

1987 • 103 citations

Human testis cDNA for the regulatory subunit RII_α of CAMP‐dependent protein kinase encodes an alternate amino‐terminal region

1989 • 91 citations

Site‐selective cyclic AMP analogs provide a new approach in the control of cancer cell growth

1987 • 90 citations

Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth.

1988 • 82 citations

Site-Selective 8 -Chloro- Cyclic Adenosine 3′,5′-Monophosphate as a Biologic Modulator of Cancer: Restoration of Normal Control Mechanisms

1989 • 81 citations

Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines

1988 • 67 citations

Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.

1989 • 58 citations

Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.

1988 • 57 citations

Hypothesis. Cyclic AMP and its receptor protein in tumor growth regulation in vivo.

1980 • 50 citations

A unique mRNA species for a regulatory subunit of cAMP‐dependent protein kinase is specifically induced in haploid germ cells

1988 • 47 citations

The separate estimation of cAMP intracellularly bound to the regulatory subunits of protein kinase I and II in glucagon-stimulated rat hepatocytes.

1985 • 44 citations

Clonal Variants of PC12 Pheochromocytoma Cells with Defects in cAMP-Dependent Protein Kinases Induce Ornithine Decarboxylase in Response to Nerve Growth Factor but not to Adenosine Agonists

1985 • 27 citations