A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid boiling method for the preparation of bacterial plasmids

1981 • 3,334 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

Comparative Anatomy of 16-S-like Ribosomal RNA

1985 • 689 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members.

1983 • 510 citations

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

1982 • 501 citations

5S RNA secondary structure

1975 • 487 citations

Making ends meet: a model for RNA splicing in fungal mitochondria

1982 • 459 citations

Conserved sequences and structures of group I introns: building an active site for RNA catalysis — a review

1988 • 451 citations

Secondary Structure of 16 S Ribosomal RNA

1981 • 446 citations

Defining the Inside and Outside of a Catalytic RNA Molecule

1989 • 368 citations

Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.

1985 • 315 citations

Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage–ligation reaction

1983 • 287 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences.

1983 • 251 citations

The secondary structure of ribonuclease P RNA, the catalytic element of a ribonucleoprotein enzyme

1988 • 213 citations

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

1986 • 211 citations

RNA binding site of R17 coat protein

1987 • 210 citations

New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing

1986 • 189 citations

Molecular genetics of group I introns: RNA structures and protein factors required for splicing — a review

1988 • 174 citations

A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNA

1984 • 171 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Close relationship between certain nuclear and mitochondrial introns

1983 • 109 citations

Three-Dimensional Structure of Transfer RNA

1976 • 95 citations

Analysis of class I introns in a mitochondrial plasmid associated with senescence of Podospora anserina reveals extraordinary resemblance to the Tetrahymena ribosomal intron

1985 • 94 citations

Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor

1986 • 81 citations

The tetrahymena rRNA intron self-splices in E. coli: In vivo evidence for the importance of key base-paired regions of RNA for RNA enzyme function

1985 • 76 citations

Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis

1985 • 56 citations

Genetic Delineation of Functional Components of the Group I Intron in the Phage T4 td Gene

1987 • 56 citations

Messenger RNA structure and gene regulation at the translational level in Escherichia coli: the case of threonine:tRNAThr ligase.

1988 • 54 citations

Coupling of Tetrahymena Ribosomal RNA Splicing to β-Galactosidase Expression in Escherichia coli

1985 • 50 citations

Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA.

1988 • 49 citations

Structures Involved in Tetrahymena rRNA Self-splicing and RNA Enzyme Activity

1987 • 46 citations

Compensatory mutations demonstrate that P8 and P6 are RNA secondary structure elements important for processing of a group I intron

1989 • 45 citations

Site-directed mutagenesis of core sequence elements 9R', 9L, 9R, and 2 in self-splicing Tetrahymena pre-rRNA.

1987 • 39 citations

Evidence of natural selection to maintain a functional domain outside of the ‘core’ in a large subclass of Group I introns

1988 • 30 citations