Oxidants and Antioxidants in Idiopathic Pulmonary Fibrosis

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Arzneimittelforschung

2005 • 8,820 citations

GLUTATHIONE

1983 • 5,487 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias

2002 • 3,947 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000 • 2,535 citations

Idiopathic Pulmonary Fibrosis

1998 • 1,255 citations

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

1988 • 1,064 citations

Oxidative stress and regulation of glutathione in lung inflammation

2000 • 890 citations

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.

1991 • 490 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.

1987 • 348 citations

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

1988 • 329 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

1997 • 280 citations

Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.

1997 • 258 citations

Potential Mediator of Inflammation

1980 • 255 citations

Oxygen toxicity

1980 • 238 citations

Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine

1988 • 234 citations

Oxygen radicals in lung pathology

1990 • 227 citations

Aerosolized Administration of N-Acetylcysteine Attenuates Lung Fibrosis Induced by Bleomycin in Mice

2000 • 208 citations

Inhibition of collagen gelation by action of the superoxide radical

1979 • 197 citations

The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis

1994 • 197 citations

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

1991 • 192 citations

Transforming Growth Factor- β₁ Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ -Glutamylcysteine Synthetase

1997 • 153 citations

Oxygen Radical Production by Alveolar Inflammatory Cells in Idiopathic Pulmonary Fibrosis

1990 • 136 citations

Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells

2000 • 135 citations

Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB 1 1Abbreviations: A549 cells, human alveolar epithelial type II cell line; AP-1, activator protein-1; BSO; dl-buthionine (SR)-sulfoximine; COPD, chronic obstructive pulmonary disease; DMEM, Dulbecco’s modified Eagle’s medium; DTT, dithiothreitol; GSHMEE, glutathione monoethyl ester; H2O2, hydrogen peroxide; IkB, inhibitory binding protein kB; LDH, lactic dehydrogenase; NAC, N-acetyl-…

2001 • 129 citations

Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells

1998 • 124 citations

WILLIAM C. ROSE: LECTURESHIP IN BIOCHEMISTRY AND NUTRITION

2009 • 119 citations

Thiol regulation of the production of TNF-α, IL-6 and IL-8 by human alveolar macrophages

1999 • 112 citations

Antioxidants, Redox-Regulated Transcription Factors, and Inflammation

1996 • 109 citations

Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals.

1995 • 107 citations

Ceramide-Mediated Apoptosis in Lung Epithelial Cells Is Regulated by Glutathione

2001 • 106 citations

Metabolism of N-acetyl-l-cysteine Some structural requirements for the deacetylation and consequences for the oral bioavailability

1989 • 103 citations

REVIEW: Methionine Sulfoxide and the Oxidative Regulation of Plasma Proteinase Inhibitors

1988 • 96 citations

The metabolism of N-acetylcysteine by human endothelial cells

1991 • 95 citations

Ethanol Ingestion Increases Activation of Matrix Metalloproteinases in Rat Lungs during Acute Endotoxemia

1999 • 90 citations

Glutathione and inflammatory disorders of the lung

1991 • 88 citations

Protective Effects of N-acetylcysteine Treatment after Phosgene Exposure in Rabbits

1995 • 86 citations

Activation of Nuclear Factor- κ B Transcriptional Activity in Airway Epithelial Cells by Thioredoxin but Not by N-Acetyl-Cysteine and Glutathione

2001 • 84 citations

Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits.

1995 • 77 citations

Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers.

1989 • 75 citations

A Controlled Study of Oxygen Metabolite Release by Alveolar Macrophages from Children with Interstitial Lung Disease

1987 • 75 citations

Increased Levels of Oxidized Methionine Residues in Bronchoalveolar Lavage Fluid Proteins from Patients with Idiopathic Pulmonary Fibrosis

1991 • 71 citations

Protection by cysteine esters against chemically induced pulmonary oedema

1991 • 70 citations

Intracellular glutathione and bronchoalveolar cells in fibrosing alveolitis: effects of N-acetylcysteine

2002 • 70 citations

Protection against pulmonary O2 toxicity by N-acetylcysteine

1989 • 66 citations

Gastrointestinal metabolism of N‐acetylcysteine in the rat, including an assay for sulfite in biological systems

1987 • 63 citations

Increased oxidation of extracellular glutathione by bronchoalveolar inflammatory cells in diffuse fibrosing alveolitis

1995 • 59 citations

Redox Paradox: Effect of N-Acetylcysteine and Serum on Oxidation Reduction–Sensitive Mitogen-Activated Protein Kinase Signaling Pathways

2001 • 56 citations

Oxidant-Protease Interaction in the Lung

1996 • 56 citations

Mitochondrial glutathione modulates TNF-α-induced endothelial cell dysfunction

1999 • 54 citations

Amiodarone Causes Acute Oxidant Lung Injury in Ventilated and Perfused Rabbit Lungs

1988 • 51 citations

The Contribution of Hypoxia‐Reperfusion Injury to Inflammatory Synovitis: The Influence of Reactive Oxygen Intermediates on the Transcriptional Control of Inflammation

1994 • 46 citations

Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury

1993 • 41 citations

Comparative loss of activity of recombinant secretory leukoprotease inhibitor and alpha 1-protease inhibitor caused by different forms of oxidative stress

1997 • 39 citations

N-acetylcysteine ameliorates hyperoxic lung injury in the preterm guinea pig

1993 • 38 citations

Oxidant-induced arachidonic acid release and impairment of fatty acid acylation in vascular smooth muscle cells

1998 • 36 citations

Pathogenetic Significance of Reactive Oxygen Species in Diffuse Fibrosing Alveolitis

1991 • 35 citations

Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron cells

1997 • 34 citations

Effects of repeated administration of N-acetyl-L-cysteine on sulfhydryl levels of different tissues and bleomycin-induced lung fibrosis in hamsters.

1988 • 28 citations

Peroxynitrite‐mediated release of arachidonic acid from PC12 cells

2000 • 27 citations

Messenger RNA levels of lung extracellular matrix proteins during ozone exposure

1994 • 20 citations

Susceptibility of cultured rat hepatocytes to oxidative stress by peroxides and iron. The extracellular matrix affects the toxicity of tert -butyl hydroperoxide

1999 • 14 citations