The metabolism of N-acetylcysteine by human endothelial cells

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

GLUTATHIONE

1983 • 5,487 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Phagocyte-generated oxygen metabolites and cellular injury.

1982 • 457 citations

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

1983 • 351 citations

Pharmacokinetics of N-acetylcysteine in man

1986 • 333 citations

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

1984 • 310 citations

Lung Protection by a Thiol-Containing Antioxidant: N-Acetylcysteine

1986 • 266 citations

Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

1986 • 235 citations

Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases.

1983 • 217 citations

Host Biochemical Defense Mechanisms Against Prooxidants

1988 • 200 citations

Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase

1986 • 199 citations

The higher oxides of nitrogen: Inhalation toxicology

1978 • 132 citations

The multiple roles of glutathione in drug metabolism

1984 • 132 citations

Enhancement of intracellular glutathione protects endothelial cells against oxidant damage

1985 • 110 citations

Human vascular smooth muscle cells and endothelial cells lack catalase activity and are susceptible to hydrogen peroxide

1985 • 89 citations

No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid.

1987 • 88 citations

Gastrointestinal metabolism of N‐acetylcysteine in the rat, including an assay for sulfite in biological systems

1987 • 63 citations

Endothelial Cell Heterogeneity: Antioxidant Profiles Determine Vulnerability to Oxidant Injury

1988 • 47 citations

Oxygen Toxicity

1975 • 43 citations

Oxidant lung injury: Intervention with sulfhydryl reagents

1985 • 38 citations

Methodologies for the analysis of reduced and oxidized N‐acetylcysteine in biological systems

1987 • 35 citations

Determination of non-protein-bound N-acetylcysteine in plasma by high-performance liquid chromatography

1984 • 25 citations

Nonxenobiotic manipulation and sulfur precursor specificity of human endothelial cell glutathione

1991 • 25 citations

Ozone-Induced Arterial Lesions

1972 • 23 citations

Trypsin protein esterase in relation to ozone-induced vascular damage.

1972 • 7 citations