Metabolism of N-acetyl-l-cysteine Some structural requirements for the deacetylation and consequences for the oral bioavailability

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

N-acetylation pharmacogenetics.

1985 • 637 citations

Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.

1979 • 624 citations

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

1983 • 351 citations

SPECIFICITY OF AMINO ACID ACYLASES

1952 • 349 citations

Pharmacokinetics of N-acetylcysteine in man

1986 • 333 citations

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

1988 • 329 citations

Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

1986 • 235 citations

Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases.

1983 • 217 citations

Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.

1986 • 200 citations

The Carboxylesterases/Amidases of Mammalian Liver and Their Possible Significance

1975 • 133 citations

Toxicological, pharmacokinetic and metabolic studies on acetylcysteine.

1980 • 117 citations

Possible Physiological Roles of Carboxylic Ester Hydrolases

1987 • 97 citations

Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different organ susceptibilities

1973 • 91 citations

[14] Amino-terminal acetylation of proteins: An overview

1984 • 90 citations

Molecular mechanics studies of enzyme-substrate interactions: the interaction of L- and D-N-acetyltryptophanamide with α-chymotrypsin

1983 • 81 citations

Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction.

1987 • 75 citations

Purification and Properties of Acylamino Acid-releasing Enzyme from Rat Liver<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1975 • 68 citations

Gastrointestinal metabolism of N‐acetylcysteine in the rat, including an assay for sulfite in biological systems

1987 • 63 citations

Purification, characterization and possible function of α-N-acylamino acid hydrolase from bovine liver

1981 • 50 citations

acid deacylase in animal tissues

1978 • 49 citations

Theory of complex molecular interactions: computer graphics, distance geometry, molecular mechanics, and quantum mechanics

1985 • 43 citations

Enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other species

1976 • 40 citations

Human erythrocyte membrane thiol methyltransferase. S-methylation of captopril, N-acetylcysteine, and 7 alpha-thio-spirolactone.

1984 • 37 citations

Deacetylation of diltiazem by rat liver.

1987 • 21 citations

Computation of peptide-protein interactions. Catalysis by chymotrypsin: prediction of relative substrate reactivities

1981 • 21 citations

The metabolism of³⁵S-D-penicillamine in man

1988 • 17 citations

Reaction with electrophiles after enzyme-catalysed deacetylation of N-acetylcysteine

1974 • 15 citations

Characterization of aspirin hydrolase of guinea-pig liver cytoplasm

1984 • 11 citations