Structures and Functions of VLA Proteins and Related Integrins

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

CELL SURFACE INTERACTIONS WITH EXTRACELLULAR MATERIALS

1983 • 1,147 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

1990 • 802 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells.

1990 • 629 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

A Synthetic Peptide Containing the IKVAV Sequence from the A Chain of Laminin Mediates Cell Attachment, Migration, and Neurite Outgrowth

1989 • 623 citations

Glanzmann's thrombasthenia: the spectrum of clinical disease

1990 • 623 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

Glanzmann's thrombasthenia: the spectrum of clinical disease

1990 • 586 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

The Leukocyte Integrins

1989 • 542 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

1985 • 518 citations

The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.

1987 • 512 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis.

1984 • 495 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.

1991 • 447 citations

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.

1988 • 446 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines.

1984 • 424 citations

The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.

1989 • 422 citations

Specific roles for platelet surface glycoproteins in platelet function

1975 • 411 citations

Membrane Proteins Involved in Phagocyte Adherence to Endothelium

1990 • 407 citations

Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

1990 • 405 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

1990 • 398 citations

The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.

1989 • 388 citations

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

1990 • 375 citations

Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency

1987 • 373 citations

The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions.

1988 • 373 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989 • 352 citations

Adhesive protein receptors on hematopoietic cells

1988 • 350 citations

Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion Functions

1990 • 345 citations

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

1989 • 343 citations

Novel function for beta 1 integrins in keratinocyte cell-cell interactions.

1990 • 338 citations

Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex.

1982 • 337 citations

N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.

1988 • 326 citations

Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi.

1988 • 323 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

1989 • 321 citations

Development of cell surface linkage complexes in cultured fibroblasts.

1985 • 320 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices.

1982 • 310 citations

The Human Laminin Receptor Is a Member of the Integrin Family of Cell Adhesion Receptors

1988 • 310 citations

Structure of vitamin D-dependent calcium-binding protein from bovine intestine

1981 • 309 citations

A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence.

1987 • 302 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture.

1985 • 293 citations

Automatic generation of primary sequence patterns from sets of related protein sequences.

1990 • 292 citations

Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.

1981 • 287 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.

1990 • 284 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.

1990 • 278 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Alpha 2 beta 1 integrins from different cell types show different binding specificities.

1990 • 274 citations

Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies.

1984 • 273 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

Electron microscopy and structural model of human fibronectin receptor.

1988 • 265 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

1988 • 258 citations

The function of PS integrins during Drosophila embryogenesis

1989 • 256 citations

Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells.

1988 • 256 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.

1990 • 249 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

1990 • 238 citations

Identification of integrin collagen receptors on human melanoma cells

1989 • 237 citations

The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

1988 • 235 citations

Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model

1986 • 232 citations

Endocytosis and recycling of the fibronectin receptor in CHO cells.

1989 • 231 citations

Tenascin mediates cell attachment through an RGD-dependent receptor.

1989 • 231 citations

Fibronectin receptor structures in the VLA family of heterodimers

1987 • 230 citations

Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.

1988 • 228 citations

Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.

1987 • 223 citations

Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas.

1989 • 221 citations

Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers

1988 • 218 citations

The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor.

1987 • 215 citations

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes.

1990 • 213 citations

Effects of Modifications of the RGD Sequence and Its Context on Recognition by the Fibronectin Receptor

1989 • 213 citations

Monoclonal Antibodies Which Alter the Morphology of Cultured Chick Myogenic Cells

1982 • 212 citations

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis.

1989 • 206 citations

Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.

1990 • 205 citations

cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms

1986 • 204 citations

Organization of the gene for platelet glycoprotein IIb

1990 • 200 citations

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

1990 • 195 citations

Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder

1988 • 194 citations

Primary sequence of a motor neuron-selective adhesive site in the synaptic basal lamina protein s-laminin

1989 • 194 citations

Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy.

1985 • 194 citations

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen.

1990 • 191 citations

Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor.

1989 • 187 citations

Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells.

1989 • 186 citations

Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures.

1988 • 186 citations

Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor .alpha.-subunits and platelet glycoprotein IIb

1987 • 183 citations

Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells.

1983 • 181 citations

Expression of normal and mutant avian integrin subunits in rodent cells [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1187]

1989 • 181 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.

1990 • 180 citations

Subunit structure of a laminin-binding integrin and localization of its binding site on laminin

1989 • 172 citations

Cloning, primary structure and properties of a novel human integrin beta subunit.

1990 • 170 citations

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

1989 • 167 citations

Analysis of the tumor-associated antigen TSP-180

1989 • 166 citations

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

1987 • 164 citations

Integrin VLA-3: ultrastructural localization at cell-cell contact sites of human cell cultures.

1989 • 163 citations

Antibody to integrin α6 subunit specifically inhibits cell-binding to laminin fragment 8

1990 • 161 citations

Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor.

1988 • 160 citations

Integrin (the CSAT antigen): functionality requires oligomeric integrity.

1986 • 160 citations

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.

1990 • 158 citations

Efficient surface expression of platelet GPIIb-IIIa requires both subunits

1989 • 158 citations

Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

1986 • 157 citations

Integrin heterodimer and receptor complexity in avian and mammalian cells.

1989 • 156 citations

Analysis of the role of glycosylation of the human fibronectin receptor

1989 • 154 citations

Identification of a neuronal laminin receptor: An Mr 200K/120K integrin heterodimer that binds laminin in a divalent cation-dependent manner

1988 • 153 citations

Leukocyte Adhesion Deficiency

1989 • 153 citations

Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells.

1985 • 153 citations

VLA‐1: a T cell surface antigen which defines a novel late stage of human T cell activation

1985 • 151 citations

Identification of the Arg‐Gly‐Asp sequence in laminin A chain as a latent cell‐binding site being exposed in fragment P1

1990 • 150 citations

Requirement for integrins during Drosophila wing development

1989 • 149 citations

Primary structure of human complement component C2 Homology to two unrelated protein families

1986 • 148 citations

Identification of a cell-surface protein involved in PC12 cell- substratum adhesion and neurite outgrowth on laminin and collagen

1989 • 142 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

Complete primary structure for the zymogen of human complement factor B.

1984 • 142 citations

Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3).

1988 • 140 citations

Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9.

1986 • 139 citations

Fibulin, a novel protein that interacts with the fibronectin receptor β subunit cytoplasmic domain

1989 • 138 citations

Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit.

1987 • 137 citations

Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor.

1989 • 135 citations

Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.

1991 • 135 citations

Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17

1988 • 134 citations

RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities.

1990 • 131 citations

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits.

1987 • 131 citations

Integrin on developing and adult skeletal muscle

1989 • 129 citations

Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits.

1988 • 126 citations

Developmentally regulated alternative splicing of Drosophila integrin PS2 α transcripts

1989 • 124 citations

Mouse heart laminin

1989 • 123 citations

An alternative cytoplasmic domain of the integrin beta 3 subunit.

1989 • 123 citations

Identification of Integrin-like Matrix Receptors with Affinity for Interstitial Collagens

1989 • 123 citations

Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin.

1990 • 122 citations

Human melanoma cells express a novel integrin receptor for laminin

1989 • 120 citations

Hepatocyte attachment to laminin is mediated through multiple receptors.

1990 • 118 citations

The 140-kDa fibronectin receptor complex is required for mesodermal cell adhesion during gastrulation in the amphibian Pleurodeles waltlii

1988 • 110 citations

Structure of the gene for cartilage matrix protein, a modular protein of the extracellular matrix

1989 • 107 citations

Biosynthesis and acquisition of biological activity of the fibronectin receptor.

1987 • 104 citations

Structural features of cartilage matrix protein deduced from cDNA.

1987 • 101 citations

Myoblast migration specifically inhibited in the chick embryo by grafted CSAT hybridoma cells secreting an anti-integrin antibody

1988 • 96 citations

Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice.

1986 • 95 citations

Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II.

1989 • 95 citations

Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

1990 • 95 citations

Human microvascular endothelial cells express integrin‐related complexes that mediate adhesion to the extracellular matrix

1989 • 93 citations

Processing and Assembly of the Integrin, Glycoprotein IIb-IIIa, in HEL Cells

1989 • 91 citations

Expression of recombinant platelet glycoprotein IIbIIIa results in a functional fibrinogen-binding complex

1989 • 90 citations

The globular domains of type VI collagen are related to the collagen-binding domains of cartilage matrix protein and von Willebrand factor.

1989 • 89 citations

Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic.

1988 • 88 citations

Evidence That Platelet Glycoprotein Ilia Has a Large Disulfidebonded Loop That Is Susceptible to Proteolytic Cleavage

1989 • 87 citations

Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function.

1983 • 87 citations

Characterization of a laminin receptor on rat hepatocytes.

1990 • 86 citations

Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.

1984 • 85 citations

A dual laminin/collagen receptor acts in peripheral nerve regeneration.

1990 • 84 citations

Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon

1985 • 80 citations

Basement membranes

1987 • 71 citations

Integrin, the cell surface receptor for fibronectin and laminin, expresses the L2/HNK-1 and L3 carbohydrate structures shared by adhesion molecules

1987 • 71 citations

Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.

1990 • 71 citations

Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the α-subunit of human platelet glycoprotein IIb

1989 • 70 citations

Distribution of the beta 1 subgroup of the integrins in human cells and tissues.

1989 • 70 citations

Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25.

1987 • 66 citations

Purification of two smooth muscle glycoproteins related to integrin. Distribution in cultured chicken embryo fibroblasts.

1987 • 65 citations

Immunogenetics of Human Cell Surface Differentiation

1989 • 63 citations

Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule.

1991 • 57 citations

Chapter 6 Toward A Molecular Explanation for Specific Cell Adhesion

1969 • 57 citations

Inhibition of Human Platelet Function in Vivo with a Monoclonal Antibody

1988 • 57 citations

Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily.

1990 • 55 citations

Internalization of the fibronectin receptor is a constitutive process

1990 • 55 citations

Kinetic and morphological evidence for endocytosis of mammalian cell integrin receptors by using an anti-fibronectin receptor β subunit monoclonal antibody

1989 • 54 citations

Bronchoalveolar Lymphocytosis in Patients with Tropical Spastic Paraparesis Associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)

1988 • 53 citations

Reduced cell adhesion to fibronectin and laminin is associated with altered glycosylation of β₁, integrins in a weakly metastatic glycosylation mutant

1989 • 48 citations

RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model.

1989 • 47 citations

Murine mRNA for the β‐subunit of integrin is increased in BALB/c‐3T3 cells entering the G₁ phase from the G₀ state

1988 • 45 citations

Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.

1987 • 45 citations

Biosynthesis and glycosylation of p150,95 and related leukocyte adhesion proteins.

1987 • 41 citations

Growth cone migration across extracellular matrix components depends on integrin, but migration across glioma cells does not

1988 • 39 citations

Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing

1990 • 37 citations

Expression and localization of the fibronectin receptor in the mouse nervous system

1988 • 32 citations

Platelet membrane glycoprotein IIb heavy chain forms a complex with glycoprotein IIIa that binds Arg-Gly-Asp peptides

1989 • 32 citations

cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells

1988 • 31 citations

Ligand-induced phosphorylation of a murine tumor surface protein (TSP-180) associated with metastatic phenotype.

1989 • 28 citations

Palmitylation of the Glycoprotein IIb-IIIa Complex in Human Blood Platelets

1989 • 27 citations

Tryptic digestion of human GPIIIa. Isolation and biochemical characterization of the 23 kDa N-terminal glycopeptide carrying the antigenic determinant for a monoclonal antibody (P37) which inhibits platelet aggregation

1988 • 27 citations

Biogenesis of the vitronectin receptor in human endothelial cell: evidence that the vitronectin receptor and GPIIb-IIIa are synthesized by a common mechanism

1989 • 25 citations

Divalent cation-dependent structure in the platelet membrane glycoprotein Ia–IIa (VLA-2) complex

1990 • 12 citations

Effect of inhibitors of N‐linked oligosaccharide processing on the cell surface expression of a melanoma integrin

1989 • 10 citations

Effect of inhibitors of glycoprotein processing on integrin and the adhesion of myoblasts to extracellular matrix proteins

1989 • 9 citations